Independent Components of Chronic Kidney Disease as a Cardiovascular Risk State

McCullough, Peter A.; Jurkovitz, Claudine; Pèrgola, Pablo E.; McGill, Janet B.; Brown, Wendy Weinstock; Collins, Allan J.; Chen, Shu‐Cheng; Li, Suying; Singh, Ajay K.; Norris, Keith C.; Klag, Michael J.; Bakris, George L.

doi:10.1001/archinte.167.11.1122

Cited by 202 publications

(103 citation statements)

References 31 publications

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“…Observations using retrospective data analyses have consistently found that CIN is associated with long-term AEs (1-5). The nature of this association is unclear (14). CIN may be a marker of the burden of comorbidities in these patients.…”

Section: Discussionmentioning

confidence: 99%

Contrast-Induced Nephropathy and Long-Term Adverse Events

Solomon

Mehran

Natarajan

et al. 2009

Clinical Journal of the American Society of Nephrology

265

163

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Background and objectives:The relationship of contrast-induced nephropathy (CIN) to long-term adverse events (AEs) is controversial. Although an association with AEs has been previously reported, it is unclear whether CIN is causally related to these AEs.Design, setting, participants, & measurements: We obtained long-term (>1 yr) follow-up on 294 patients who participated in a randomized, double-blind comparison of two prevention strategies for CIN (iopamidol versus iodixanol). A difference in the incidence of AEs between patients who had developed CIN and those who had not was performed using a 2 test and Poisson regression analysis. A similar statistical approach was used for the differences in AEs between those who received iopamidol or iodixanol. Multiple definitions of CIN were used to strengthen and validate the results and conclusions.Results: The rate of long-term AEs was higher in individuals with CIN (all definitions of CIN). After adjustment for baseline comorbidities and risk factors, the adjusted incidence rate ratio for AEs was twice as high in those with CIN. Randomization to iopamidol reduced both the incidence of CIN and AEs.Conclusions: The parallel decrease in the incidence of CIN and AEs in one arm of this randomized trial supports a causal role for CIN.

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Section: Discussionmentioning

confidence: 99%

Contrast-Induced Nephropathy and Long-Term Adverse Events

Solomon

Mehran

Natarajan

et al. 2009

Clinical Journal of the American Society of Nephrology

265

163

View full text Add to dashboard Cite

show abstract

“…The increased risk for CV events and mortality in people over 55 with CKD alone is equivalent, or even higher, to that seen in patients with diabetes or previous myocardial infarcts [11]. Both general [6,12] and high-risk populations [13,14] exhibit an increased risk of CVD with CKD. This increased risk for CVD is not confined to the elderly-in volunteers with an average age of 45, the risk for myocardial infarct, stroke, and all cause mortality was doubled in those with CKD [14].…”

Section: Cardiovascular Disease and The Kidneymentioning

confidence: 96%

World Kidney Day 2011: Protect your kidneys, save your heart

Couser

Riella²

2011

Pediatr Nephrol

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“…Доказано, что гомоцистеин обладает токсическими свой-ствами, проявляющимися в развитии аутоиммунных реакций и прогрессировании атеросклероза [32]. В проведенных исследова-ниях установлено, что повышение концентрации гомоцистеина является независимым ФР развития ССЗ [33].…”

Section: терапевтический архив 1 2015unclassified