Prophet Muhammad leads the world's most influential figure in the world as western writers determined beside the great figure of religion. In the 21st century, Prophet Muhammad deserves to become a figure with entrepreneurial characters. Through the study of microhistory, the stories of Prophet Muhammad were identified, classified, and interpreted as stories that contain the values of an entrepreneur character. The results from a study of several biographical books of Prophet Muhammad found that four stories constantly experienced by the Prophet Muhammad such as: business, failure, suffering, and success. Then, these four stories were interpreted into four entrepreneurial characters of Prophet Muhammad, namely: creative, brave, survival, and independent. These values were universal and can be taught for historical learning across cultures, religions, and generations.