Independent predictors of mortality and 5-year trends in mortality and resource utilization in hospitalized patients with diffuse large B cell lymphoma

Bodla, Zubair Hassan; Hashmi, Mariam; Niaz, Fatima; Farooq, Umer; Khalid, Farhan; Tariq, Muhammad Junaid; Khalil, Muhammad Jahanzeb; Brown, Victoria S.; Bray, Christopher L.

doi:10.1080/08998280.2023.2267921

Cited by 3 publications

(1 citation statement)

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“…The univariate analysis was conducted to identify potential confounding factors. All confounders that displayed a significant relationship with the outcome, using a p -value threshold of 0.2 [ 11 ], were integrated into the multivariate model. Furthermore, variables deemed clinically relevant to the outcome from previous studies were included in the model, irrespective of their significance in the univariate analysis.…”

Section: Methodsmentioning

confidence: 99%

Double Trouble: COVID-19 Infection Exacerbates Sickle Cell Crisis Outcomes in Hospitalized Patients—Insights from National Inpatient Sample 2020

Bodla,

Hashmi,

Niaz

et al. 2024

Hematology Reports

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Background: This study investigated the impact of COVID-19 on patients with sickle cell crisis (SCC) using National Inpatient Sample (NIS) data for the year 2020. Methods: A retrospective cohort analysis was conducted utilizing International Classification of Diseases (ICD-10) codes to identify adults who were admitted with a principal diagnosis of sickle cell crisis. The primary outcomes examined were inpatient mortality, while the secondary outcomes assessed included morbidity, hospital length of stay, and resource utilization. Analyses were conducted with STATA. Multivariate logistic and linear regression analyses were used to adjust for confounding variables. Results: Of 66,415 adult patients with a primary SCC diagnosis, 875 were identified with a secondary diagnosis of COVID-19 infection. Unadjusted mortality rate was higher for SCC patients with COVID-19 (2.28%) compared to those without (0.33%), with an adjusted odds ratio (aOR) of 8.49 (p = 0.001). They also showed increased odds of developing acute respiratory failure (aOR = 2.37, p = 0.003) and acute kidney injury requiring dialysis (aOR = 8.66, p = 0.034). Additionally, these patients had longer hospital stays by an adjusted mean of 3.30 days (p < 0.001) and incurred higher hospitalization charges by an adjusted mean of USD 35,578 (p = 0.005). Conclusions: The SCC patients with COVID-19 presented higher mortality rates, increased morbidity indicators, longer hospital stays, and substantial economic burdens.

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Section: Methodsmentioning

confidence: 99%