Independent predictors of survival in endometrium cancer: platelet-to-lymphocyte ratio and platelet/neutrophil/monocyte-to-lymphocyte ratio

Abstract

Objective:To evaluate the association between ratios of inflammatory markers and survival in endometrium cancer (EC).Material and Methods:Four hundred ninety-seven patients with epithelial EC were included. The evaluated ratios were neutrophil (N)/lymphocyte (L), neutrophil count divided by the lymphocyte count; platelet (P)/lymphocyte, platelets divided by the lymphocyte count; lymphocyte/monocyte (M), lymphocytes divided by the monocyte count; NM/L, neutrophil plus monocyte divided by the lymphocyte count; PNM/L, the sum total counts of platelets, neutrophils and monocytes divided by the lymphocyte count.Results:The median follow-up time was 24 months (1-129). Recurrence and exitus occurred in 34 (7%) and 18 (3.7%) patients, respectively. Metastasis in pelvic or para-aortic lymph nodes were significantly related only with low L/M. None of the inflammatory ratios were associated with disease-free survival. In multi-variant analysis, only high P/L (>168) and high PNM/L (>171) were related with a statistically significant hazard ratio for death of 2.91 (p=0.024) and 2.93 (p=0.023), respectively.Conclusion:The P/L and PNM/L were in relation with worse overall survival and also independent prognostic factors for OS.

Prognostic values of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in endometrial cancer: a systematic review and meta-analysis

“…OS. Comert et al [13] found that PLR was an independent prognostic marker for OS, but NLR was not a significant indicator. Prognostic values of NLR and PLR in EC are unclear.…”

“…Six original papers reported that NLR was an independent predictor for a shortened OS in patients with EC [12,[15][16][17][18][19], while NLR was not identified as a prognostic factor for OS in three studies [13,20,21]. The combined analysis of nine publications showed that the NLR values higher than the cut-off value predicted a worse OS (pHR = 2.22, 95% CI 1.77-2.78, Fig.…”

“…The combined analysis of nine publications showed that the NLR values higher than the cut-off value predicted a worse OS (pHR = 2.22, 95% CI 1.77-2.78, Fig. 2) in individuals with EC [12,13,[15][16][17][18][19][20][21].…”

“…Pooled analysis of five studies that included 1798 participants revealed that a higher NLR level was associated with worse DFS (pHR = 1.81, 95% CI 1.35-2.41, Fig. 3) [12,13,[16][17][18].…”

Survival and prognostic analysis of preoperative indicators in patients undergoing surgical resections with rhabdomyosarcoma

“…Neutrophils, monocytes, and lymphocytes are regarded as important elements in both the innate and adaptive immune response, playing a big role in the direct elimination of harmful substances, the secretion and mediation of chemokines and molecules, and the cascade activation of a series of cells and activities. [ 28 , 29 ] Platelets were previously understood as a core element in blood coagulation and thrombus formation process, but presently platelets are also considered to release several kinds of pro-inflammatory or inflammatory molecules which are essential in the cascade reaction. [ 30 ] In other words, besides coagulation, platelets also interact with various elements in the immune systems.…”