Independent validation of four‐dimensional flow MR velocities and vortex ring volume using particle imaging velocimetry and planar laser‐Induced fluorescence

Töger, Johannes; Bidhult, Sebastian; Revstedt, Johan; Carlsson, Marcus; Arheden, Håkan; Heiberg, Einar

doi:10.1002/mrm.25683

Cited by 37 publications

(46 citation statements)

References 38 publications

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“…4D PC-MRI flow acquisitions and cine images were acquired as previously described and validated in vivo and in vitro [24, 25]. In short, images were acquired using retrospective ECG triggering, with a 1.5 or 3 T Philips Achieva MRI.…”

Section: Methodsmentioning

confidence: 99%

Decreased Diastolic Ventricular Kinetic Energy in Young Patients with Fontan Circulation Demonstrated by Four-Dimensional Cardiac Magnetic Resonance Imaging

et al. 2017

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Four-dimensional (4D) flow magnetic resonance imaging (MRI) enables quantification of kinetic energy (KE) in intraventricular blood flow. This provides a novel way to understand the cardiovascular physiology of the Fontan circulation. In this study, we aimed to quantify the KE in functional single ventricles. 4D flow MRI was acquired in eleven patients with Fontan circulation (median age 12 years, range 3–29) and eight healthy volunteers (median age 26 years, range 23–36). Follow-up MRI after surgical or percutaneous intervention was performed in 3 patients. Intraventricular KE was calculated throughout the cardiac cycle and indexed to stroke volume (SV). The systolic/diastolic ratio of KE in Fontan patients was similar to the ratio of the controls’ left ventricle (LV) or right ventricle (RV) depending on the patients’ ventricular morphology (Cohen´s κ = 1.0). Peak systolic KE/SV did not differ in patients compared to the LV in controls (0.016 ± 0.006 mJ/ml vs 0.020 ± 0.004 mJ/ml, p = 0.09). Peak diastolic KE/SV in Fontan patients was lower than in the LV of the control group (0.028 ± 0.010 mJ/ml vs 0.057 ± 0.011 mJ/ml, p < 0.0001). The KE during diastole showed a plateau in patients with aortopulmonary collaterals. This is to our knowledge the first study that quantifies the intraventricular KE of Fontan patients. KE is dependent on the morphology of the ventricle, and diastolic KE indexed to SV in patients is decreased compared to controls. The lower KE in Fontan patients may be a result of impaired ventricular filling.Electronic supplementary materialThe online version of this article (doi:10.1007/s00246-016-1565-6) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Decreased Diastolic Ventricular Kinetic Energy in Young Patients with Fontan Circulation Demonstrated by Four-Dimensional Cardiac Magnetic Resonance Imaging

et al. 2017

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“…One series of experiments was conducted with water, with Reynolds numbers ranging from 5200 to 8900. A second series of experiments was performed using a water‐glycerine mixture as previously described to investigate if higher fluid viscosity and increased temporal and spatial resolution would influence mixing quantification. As a consequence of increasing the viscosity to match the viscosity of blood, the Reynolds numbers in the water–glycerine experiments were lower compared to the water experiments (1800–2900).…”

Section: Methodsmentioning

confidence: 99%

“…PLIF flow visualization (Fig. c) was performed using a LaVision flow imaging system (Göttingen, Germany) as previously described …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Vortex‐ring mixing as a measure of diastolic function of the human heart: Phantom validation and initial observations in healthy volunteers and patients with heart failure

Töger

Kanski

Arvidsson

et al. 2015

Magnetic Resonance Imaging

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Vortex-ring mixing as a measure of diastolic function of the human heart: Phantom validation and initial observations in healthy volunteers and patients with heart failure.Töger, Johannes; Kanski, Mikael; Arvidsson, Per; Carlsson, Marcus; Kovács, Sándor J; Borgquist, Rasmus; Revstedt, Johan; Söderlind, Gustaf; Arheden, Håkan; Heiberg, Einar Link to publication Citation for published version (APA): Töger, J., Kanski, M., Arvidsson, P., Carlsson, M., Kovács, S. J., Borgquist, R., ... Heiberg, E. (2016). Vortex-ring mixing as a measure of diastolic function of the human heart: Phantom validation and initial observations in healthy volunteers and patients with heart failure. Journal of Magnetic Resonance Imaging, 43(6), 1386-1397. DOI: 10.1002/jmri.25111General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Running titleVortex ring mixing in the left ventricle 3 ABSTRACT PurposeTo present and validate a new method for 4D flow quantification of vortex-ring mixing during early, rapid filling of the left ventricle (LV) as a potential index of diastolic dysfunction and heart failure. Materials and Methods4D flow mixing measurements were validated using planar laser-induced fluorescence (PLIF) in a phantom setup. Controls (n=23) and heart failure patients (n=23) were studied using 4D flow at 1.5T (26 subjects) or 3T (20 subjects) to determine vortex volume (VV) and inflowing volume (VV inflow ). The volume mixed into the vortex-ring was quantified as VV mix-in = VV-VV inflow . The mixing ratio was defined as MXR = VV mix-in /VV. Furthermore, we quantified the fraction of the end-systolic volume (ESV) mixed into the vortex-ring (VV mix-in /ESV) and the fraction of the LV volume at diastasis (DV) occupied by the vortex-ring (VV/DV). ResultsPLIF validation of MXR showed fair agreement (R 2 =0.45, mean±SD 1±6%). MXR was higher in patients compared to controls (28±11% vs 16±10%, p<0.001), while VV mix-in /ESV and VV/DV were lower in patients (10±6% vs 18±12%, p<0.01 and 25±8% vs 50±6%, p<0.0001). ConclusionVortex-ring mixing can be quantified using 4D flow. The differences in mixing parameters observed between controls and patients motivate further investigation as indices of diastolic dysfunction.4

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Variability of 4D flow parameters when subjected to changes in MRI acquisition parameters using a realistic thoracic aortic phantom

Montalba

Urbina

Sotelo

et al. 2017

Magnetic Resonance in Med

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Independent validation of four‐dimensional flow MR velocities and vortex ring volume using particle imaging velocimetry and planar laser‐Induced fluorescence

Abstract: This study shows: (i) The proposed phantom enables reliable validation of 4D flow. (ii) 4D flow velocities show good agreement with PIV, but peak velocities were underestimated due to low spatial and temporal resolution. (iii) Vortex ring volume (VV) can be quantified using 4D flow.

Cited by 37 publications

References 38 publications

Decreased Diastolic Ventricular Kinetic Energy in Young Patients with Fontan Circulation Demonstrated by Four-Dimensional Cardiac Magnetic Resonance Imaging

Decreased Diastolic Ventricular Kinetic Energy in Young Patients with Fontan Circulation Demonstrated by Four-Dimensional Cardiac Magnetic Resonance Imaging

Vortex‐ring mixing as a measure of diastolic function of the human heart: Phantom validation and initial observations in healthy volunteers and patients with heart failure

Variability of 4D flow parameters when subjected to changes in MRI acquisition parameters using a realistic thoracic aortic phantom

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