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Hager, Anna; Hager, Everett Gordon

doi:10.1525/9780520333918

Cited by 2 publications

(2 citation statements)

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“…Zero neutral loss scans in tandem mass spectrometry have not been used in real applications. However, it has been indicated in the literature that a combination of ZNL with CID on a triple-quadrupole mass spectrometer may reduce the intensities of dissociable chemical noise ions if analyte ions can survive the collision energy needed to fragment noise ions. In our study changes of m / z of background ions are the result of exclusive reactions with a reagent.…”

Section: Resultsmentioning

confidence: 99%

Method To Reduce Chemical Background Interference in Atmospheric Pressure Ionization Liquid Chromatography−Mass Spectrometry Using Exclusive Reactions with the Chemical Reagent Dimethyl Disulfide

2007

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The interference of chemical background ions (chemical noise) has been a problem since the inception of mass spectrometry. We present here a novel method to reduce the chemical noise in LC-MS based on exclusive gas-phase reactions with a reactive collision gas in a triple-quadrupole mass spectrometer. Combined with the zero neutral loss (ZNL) scan of a triple-quadrupole mass spectrometer, the reactive chemical noise ions can be removed because of shifts of mass-to-charge ratios from the original background ions. The test on various classes of compounds with different functional groups indicates a generic application of this technique in LC-MS. The preliminary results show that a reduction of the level of LC-MS base-peak chromatographic baseline by a factor up to 40 and an improvement of the signal-to-noise ratio by a factor up to 5-10 are achieved on both commercial and custom-modified triple-quadrupole LC-MS systems. Application is foreseen in both quantitative and qualitative trace analysis. It is expected that this chemical noise reduction technique can be optimized on a dedicated mass spectrometric instrumentation which incorporates both a chemical reaction cell for noise reduction and a collision stage for fragmentation.

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Section: Resultsmentioning

confidence: 99%

Method To Reduce Chemical Background Interference in Atmospheric Pressure Ionization Liquid Chromatography−Mass Spectrometry Using Exclusive Reactions with the Chemical Reagent Dimethyl Disulfide

2007

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“…In the mid-1960s, only 6 percent of the students enrolled in U.S. medical schools were women [1]. By the mid-1970s, the number of women graduating from U.S. medical schools had risen to only 16 percent [2]. By the 2004-2005 academic year, women represented 50 percent of applicants, 49 percent of matriculating medical students, 47 percent of graduates of U.S. medical schools, and 42 percent of residents and fellows [3].…”

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confidence: 99%

Women in Medicine: Recognition and Responsibility

Loewy

2008

AMA Journal of Ethics

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Cited by 2 publications

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Method To Reduce Chemical Background Interference in Atmospheric Pressure Ionization Liquid Chromatography−Mass Spectrometry Using Exclusive Reactions with the Chemical Reagent Dimethyl Disulfide

Method To Reduce Chemical Background Interference in Atmospheric Pressure Ionization Liquid Chromatography−Mass Spectrometry Using Exclusive Reactions with the Chemical Reagent Dimethyl Disulfide

Women in Medicine: Recognition and Responsibility

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