“…The clinical indication for and the timing of surgery, however, remains a grey area. In general, about 20% of patients with a first episode of biliary colic undergo cholecystectomy,4 but some experts argue that all patients with definite symptoms should have their gallbladder removed quickly 5. Furthermore, about one in five patients with symptomatic gallstone disease prefers non-surgical management,6 and about half of all patients treated conservatively have no further symptoms over the next 10 years 7.…”