Index Cluster Study of Dengue Virus Infection in Nicaragua

Reyes, Miguel; Mercado, Juan Carlos; Standish, Katherine; Matute, Juan Carlos; Ortega, Oscar; Moraga, B Luis; Avilés, William; Henn, Matthew R.; Balmaseda, Ángel; Kuan, Guillermina; Harris, Eva

doi:10.4269/ajtmh.2010.10-0023

Cited by 35 publications

(34 citation statements)

References 24 publications

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“…Eighteen studies were identified for Central America and included data from Costa Rica [17–22]; Honduras [23, 24]; Nicaragua [25–32]; and Panama [33]. Specific data from the other countries in Central America (Belize, El Salvador, and Guatemala) were included as part of a wider review of dengue in the Americas [16].…”

Section: Resultsmentioning

confidence: 99%

“…Specific data from the other countries in Central America (Belize, El Salvador, and Guatemala) were included as part of a wider review of dengue in the Americas [16]. DENV-2 circulated almost continuously from 2000 to 2008 (except for 2002) [18, 25, 28, 32] and was replaced by DENV-3 from 2008 to 2011 [32]. DENV-1 also circulated from 1999 to 2008 [21, 22, 24, 28, 30] and DENV-4 from 1999 to 2001 [25].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature

Torres

Orduña²,

Piña-Pozas

et al. 2017

Journal of Tropical Medicine

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Dengue, an important mosquito-borne virus transmitted mainly by Aedes aegypti, is a major public health issue in Latin America and the Caribbean. National epidemiological surveillance systems, usually based on passive detection of symptomatic cases, while underestimating the true burden of dengue disease, can provide valuable insight into disease trends and excess reporting and potential outbreaks. We carried out a systematic review of the literature to characterize the recent epidemiology of dengue disease in Latin America and the English-speaking and Hispanic Caribbean Islands. We identified 530 articles, 60 of which met criteria for inclusion. In general, dengue seropositivity across the region was high and increased with age. All four virus serotypes were reported to circulate in the region. These observations varied considerably between and within countries and over time, potentially due to climatic factors (temperature, rainfall, and relative humidity) and their effect on mosquito densities and differences in socioeconomic factors. This review provides important insight into the major epidemiological characteristics of dengue in distinct regions of Latin America and the Caribbean, allowing gaps in current knowledge and future research needs to be identified.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature

Torres

Orduña²,

Piña-Pozas

et al. 2017

Journal of Tropical Medicine

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“…Earlier cluster investigation methods were designed as an alternative approach to the commonly used prospective cohort study method for investigating the natural history of dengue virus infection in South-East Asia and Latin America [13], [30]. Although different study designs have demonstrated the feasibility of identification of inapparent dengue cases, it remains difficult to recruit these subjects.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Virological Study of Dengue Cases and the Members of Their Households: The Multinational DENFRAME Project

et al. 2012

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BackgroundDengue has emerged as the most important vector-borne viral disease in tropical areas. Evaluations of the burden and severity of dengue disease have been hindered by the frequent lack of laboratory confirmation and strong selection bias toward more severe cases.MethodologyA multinational, prospective clinical study was carried out in South-East Asia (SEA) and Latin America (LA), to ascertain the proportion of inapparent dengue infections in households of febrile dengue cases, and to compare clinical data and biological markers from subjects with various dengue disease patterns. Dengue infection was laboratory-confirmed during the acute phase, by virus isolation and detection of the genome. The four participating reference laboratories used standardized methods.Principal FindingsAmong 215 febrile dengue subjects—114 in SEA and 101 in LA—28 (13.0%) were diagnosed with severe dengue (from SEA only) using the WHO definition. Household investigations were carried out for 177 febrile subjects. Among household members at the time of the first home visit, 39 acute dengue infections were detected of which 29 were inapparent. A further 62 dengue cases were classified at early convalescent phase. Therefore, 101 dengue infections were found among the 408 household members. Adding these together with the 177 Dengue Index Cases, the overall proportion of dengue infections among the study participants was estimated at 47.5% (278/585; 95% CI 43.5–51.6). Lymphocyte counts and detection of the NS1 antigen differed significantly between inapparent and symptomatic dengue subjects; among inapparent cases lymphocyte counts were normal and only 20% were positive for NS1 antigen. Primary dengue infection and a specific dengue virus serotype were not associated with symptomatic dengue infection.ConclusionHousehold investigation demonstrated a high proportion of household members positive for dengue infection, including a number of inapparent cases, the frequency of which was higher in SEA than in LA.

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“…Active surveillance of human infections can be efficiently achieved using geographical cluster sampling around dengue index cases. 25,26 Here, ‘index case’ refers to the laboratory-diagnosed clinical dengue case that initiates a cluster investigation within a geographically restricted area around the home of a person with a documented DENV infection. Geographical cluster investigations could be used to compare the fine-scale spatial signature of DENV transmission in areas with and without Wolbachia (Figure 2).…”

Section: A Pragmatic Approach To Optimize Wolbachia Deploymentmentioning

confidence: 99%

Assessing the epidemiological effect of wolbachia for dengue control

Lambrechts

Ferguson

Harris

et al. 2015

The Lancet Infectious Diseases

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Summary Dengue viruses cause more human morbidity and mortality than any other arthropod-borne virus. Dengue prevention relies primarily on vector control but the failure of traditional methods has promoted the development of novel entomological approaches. Although use of the intracellular bacterium Wolbachia to control mosquito populations was proposed half a century ago, it has only gained significant interest as a potential agent of dengue control in the last decade. Here, we review the evidence that supports a practical approach for dengue reduction through field release of Wolbachia-infected mosquitoes and discuss the additional studies that must be conducted before the strategy can be validated and operationally implemented. A critical next step is to assess the efficacy of Wolbachia deployment in reducing dengue virus transmission. We argue that a cluster-randomized trial is currently premature because Wolbachia strain choice for release as well as deployment strategies are still being optimized. We therefore present a pragmatic approach to acquiring preliminary evidence of efficacy via a suite of complementary methodologies: prospective cohort study, geographical cluster investigation, virus phylogenetic analysis, virus surveillance in mosquitoes, and vector competence assays. This multi-pronged approach could provide valuable intermediate evidence of efficacy to justify a future cluster-randomized trial.

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Index Cluster Study of Dengue Virus Infection in Nicaragua

Cited by 35 publications

References 24 publications

Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature

Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature

Clinical and Virological Study of Dengue Cases and the Members of Their Households: The Multinational DENFRAME Project

Assessing the epidemiological effect of wolbachia for dengue control

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