Index of the Mayo Endoscopy and Ulcerative Colitis Endoscopy Index of Severity: are they equally valid?

Hergueta-Delgado, Pedro; Rodríguez, Blas José Gómez; Pérez, Belen Maldonado; Laria, Luisa Castro; Rodríguez-Téllez, Manuel; Barroso, María Luisa Morales; Fernández, María Dolores Galván; Veloz, María Fernanda Guerra; García, Victoria Alejandra Jiménez; Castro, R. Romero; Roldán, A. Benítez; Márquez, Cristina Castro; Flórez-López, Raquel; Serrano, Antonio Garrido; Álvarez, Ángel Caunedo; Arias, Federico Argüelles

doi:10.17235/reed.2020.6832/2019

Cited by 3 publications

(3 citation statements)

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“…Fourthly, it is essential to assess the agreement among endoscopists for the TIGER score. Studies have demonstrated adequate, though not perfect, correlation between different endoscopists when using MES or UCEIS in UC patients[ 8 ], but agreement among endoscopists for the TIGER score has not been conclusively demonstrated[ 9 ].…”

Section: To the Editormentioning

confidence: 99%

Are we ready to use new endoscopic scores for ulcerative colitis?

Quera,

Núñez F

2024

World J Gastroenterol

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For ulcerative colitis (UC), the variability in inflammatory activity along the colon poses a challenge in management. The focus on achieving endoscopic healing in UC is evident, where the UC Endoscopic Index of Severity and Mayo Endoscopic Subscore are commonly used for evaluation. However, these indices primarily consider the most severely affected region. Liu et al recent study validates the Toronto Inflammatory Bowel Disease Global Endoscopic Reporting (TIGER) score offering a comprehensive assessment of inflammatory activity across diverse segments of the colon and rectum and a reliable index correlating strongly with UC Endoscopic Index of Severity and moderately with Mayo Endoscopic Subscore (MES). Despite recommendation, certain aspects warrant further investigation. Fecal calprotectin, an intermediate target, correlates with TIGER and should be explored. Determining TIGER scores defining endoscopic remission and response, evaluating agreement with histological activity, and assessing inter-endoscopist agreement for TIGER require scrutiny. Exploring the correlation between TIGER and intestinal ultrasound, akin to MES, adds value.

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Section: To the Editormentioning

confidence: 99%

Are we ready to use new endoscopic scores for ulcerative colitis?

Quera,

Núñez F

2024

World J Gastroenterol

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“…Mucosal ulcer is an early event in the occurrence mechanism of UC, and repair after mucosal injury is used as an important index to evaluate the e cacy of drugs [24]. Colonoscopy is currently an important method to clinically evaluate the healing of intestinal mucosal injury after the treatment of UC patients [25,26]. In this study, we referred to the clinically common Baron endoscopy score and Mayo enteroscopy score for the pathological manifestations of experimental colitis, focused on mucosal damage and intestinal hemorrhage, redness, and developed a colonoscopy score criterion for experimental colitis animal model, so as to evaluate the repairing effect of Ento-PB after intestinal mucosal injury in experimental colitis dogs.…”

Section: Ento-pb Regulated the Expression Of In Ammatory Cytokines Inmentioning

confidence: 99%

Dynamic Evaluation of Compound Ento-PB for the Repair of Mucosal Ulcer in Dogs With Acetic Acid-induced Experimental Colitis 

Chen¹,

Zhao²,

Z³

et al. 2020

Preprint

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Background: Mucosal inflammation and ulcer play important roles in the pathogenesis of ulcerative colitis. As as traditional Chinese medicine compound composed of Periplaneta americana and Taraxacum mongolicum, Ento-PB is always prescribed for the treatment of ulcer and inflammatory diseases. As for the significant role of P. americana in terms of promoting mucosal healing, the compatibility of the anti-inflammatory drug T. mongolicum may enable Ento-PB to simultaneously play anti-inflammatory and promote mucosal healing effects on the treatment of UC. Therefore, this study aimed to evaluate the therapeutic potential and possible mechanism of Ento-PB for UC by establishing an acetic acid-induced colitis model in dogs.Methods: Preliminary identification to the chemical components of compound Ento-PB was carried out through high performance liquid chromatography. A cross-bred dogs model of acetic acid-induced ulcerative colitis was established to evaluate the efficacy of compound Ento-PB. The expression levels of inflammatory cytokines C-reactive protein (CRP), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-10 (IL-10) in plasma were measured by carrying out enzyme-linked immunosorbent assay (ELISA).Results: With the extension of treatment time, Ento-PB could effectively improve clinical symptoms of UC cross-bred dogs. Colonoscopy displayed that mucosal redness, swelling and congestion decreased gradually, and obviously repaired after mucosal injury. The intestinal texture was gradually clear, and the colonoscopy score gradually reduced. Histopathological examination revealed that the structure of colon was restored significantly, the infiltration of inflammatory cells was reduced, and the histological score was remarkably reduced. At the same time, the results of dynamic monitoring of inflammatory cytokines in plasma proved that Ento-PB can gradually down-regulate the activity of CRP, iNOS and COX-2, reduce the expression levels of inflammatory cytokines TNF-α and IL-1β, and gradually restore anti-inflammatory and the expression level of cytokine IL-10.Conclusions: Ento-PB reduces the level of pro-inflammatory cytokines in a dose- and time-dependent manner and inflammation, improves colon tissue lesions and the repair of intestinal mucosa after injury, and effectively increases acetic acid-induced colon inflammation in UC cross-bred dogs.

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“…[ 2 ] Moreover, the Endoscopic Mayo score has its limitations for assessing the clinical outcomes and predicting prognosis in UC compared with other scores, for example, the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). [ 3 4 ]…”

mentioning

confidence: 99%

UDCA in UC

Sulais

2021

Saudi Journal of Gastroenterology

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Index of the Mayo Endoscopy and Ulcerative Colitis Endoscopy Index of Severity: are they equally valid?

Cited by 3 publications

References 0 publications

Are we ready to use new endoscopic scores for ulcerative colitis?

Are we ready to use new endoscopic scores for ulcerative colitis?

Dynamic Evaluation of Compound Ento-PB for the Repair of Mucosal Ulcer in Dogs With Acetic Acid-induced Experimental Colitis

UDCA in UC

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Index of the Mayo Endoscopy and Ulcerative Colitis Endoscopy Index of Severity: are they equally valid?

Cited by 3 publications

References 0 publications

Are we ready to use new endoscopic scores for ulcerative colitis?

Are we ready to use new endoscopic scores for ulcerative colitis?

Dynamic Evaluation of Compound Ento-PB&nbsp;for the Repair of Mucosal Ulcer in Dogs With Acetic Acid-induced Experimental Colitis&nbsp;

UDCA in UC

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Product

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Dynamic Evaluation of Compound Ento-PB for the Repair of Mucosal Ulcer in Dogs With Acetic Acid-induced Experimental Colitis