Indexes of adiposity and body composition in the prediction of metabolic syndrome in obese children and adolescents: Which is the best?

Radetti, Giorgio; Fanolla, Antonio; Grugni, Graziano; Lupi, Fiorenzo; Sartório, Alessandro

doi:10.1016/j.numecd.2019.06.011

Cited by 25 publications

(33 citation statements)

References 33 publications

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“…Even so, our results could be important from a rehabilitative point of view, adding value in the clinical and therapeutic management of PWS and increasing awareness of this rare pathological condition. Interestingly, our results are similar to those observed in a pediatric population of subjects with essential obesity [11], suggesting the opportunity to perform a similar investigation in both children and adolescents with PWS.…”

Section: Discussionsupporting

confidence: 87%

“…In a paper evaluating a large group of obese children and adolescents, we have recently compared different indexes of adiposity, body composition and body fat distribution, including also the body mass fat index (BMFI), which adjusts the BMI for the body composition and for the WC, in order to verify their ability in identifying MetS [11]. The main outcome of this paper was that BMI, which does not take into account body composition and fat distribution, showed the same accuracy as the other indexes, thus resulting in it being the best to be considered, also due to its easiness of calculation.…”

Section: Introductionmentioning

confidence: 99%

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Accuracy of Different Indexes of Body Composition and Adiposity in Identifying Metabolic Syndrome in Adult Subjects with Prader-Willi Syndrome

Radetti

Fanolla²,

Lupi

et al. 2020

JCM

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(1) Objective: To compare the accuracy of different indexes of adiposity and/or body composition in identifying metabolic syndrome (MetS) in adult patients suffering from Prader‒Willi syndrome (PWS). (2) Study Design: One hundred and twenty PWS patients (69 females and 51 males), aged 29.1 ± 9.4 years, body mass index (BMI) 36.7 ± 9.9, were evaluated. The following indexes were assessed in each subject: body mass index (BMI), fat-free mass index (FFMI), fat mass index (FMI), tri-ponderal mass index (TMI), waist-to-height ratio (WtHR) and the body mass fat index (BMFI), which adjusts the BMI for the percentage of body fat and waist circumference. Thereafter, a threshold value adjusted for age and sex, which could identify MetS, was calculated for each index. (3) Results: A significant correlation was found among all indexes (p < 0.0001 for all). However, when the area under the curve (AUC) was compared, BMFI performed better than FMI (p < 0.05) and BMI better than TMI (p < 0.05), but only in females. (4) Conclusions: Besides small differences, all the indexes taken into consideration seem to have the same ability to identify MetS in adults with PWS. Consequently, the most easily calculated index, i.e., BMI, should be considered as the best choice. The use of thresholds appropriate for sex and age can further improve its accuracy.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Accuracy of Different Indexes of Body Composition and Adiposity in Identifying Metabolic Syndrome in Adult Subjects with Prader-Willi Syndrome

Radetti

Fanolla²,

Lupi

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

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“…In absence of data to calculate WHtR, BMI, a marker of obesity, may be used as predictor of hypertension in youths and young adults with diabetes. Previous studies in children have shown that BMI correlated reasonably well with body fat 44 and is comparable with WHtR in performance as predictor of metabolic syndrome 45 and hypertension 15 in children. However, in youths with diabetes, central obesity may be a better indicator of risk for diabetes‐related complications than BMI 6,11 .…”

Section: Discussionmentioning

confidence: 69%

Progression to hypertension in youth and young adults with type 1 or type 2 diabetes: The SEARCH for Diabetes in Youth Study

Koebnick

Imperatore

Jensen

et al. 2020

J of Clinical Hypertension

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Central obesity may contribute to the development of hypertension in youths with diabetes. The SEARCH for Diabetes in Youth Study followed 1518 youths with type 1 diabetes (T1D) and 177 with type 2 diabetes (T2D) diagnosed when <20 years of age for incident hypertension. Incident hypertension was defined as blood pressure ≥95th percentile (or ≥130/80 mm Hg) or reporting antihypertensive therapy among those without hypertension at baseline. Poisson regression models were stratified by diabetes type and included demographic and clinical factors, clinical site, and waistto-height ratio (WHtR). Youths with T2D were more likely to develop hypertension than those with T1D (35.6% vs 14.8%, P < .0001). For each 0.01 unit of annual increase in WHtR, adjusted relative risk for hypertension was 1.53 (95% CI 1.36-1.73) and 1.20 (95% CI 1.00-1.43) for youths with T1D and T2D, respectively. Effective strategies targeted toward reducing central obesity may reduce hypertension among youths with diabetes.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. ET Jensen, JM Stafford, and RB D'Agostino, Jr. performed statistical analysis. D Dabelea, RB D'Agostino, Jr., and JM Lawrence obtained funding. | 895 KOEBNICK Et al.

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“…According to a recent report study, approximately 44.3% of obese children have characteristics of MS, and lower percentage of normal weight children have only one risk factor of MS. 21 Another study even showed a higher prevalence (70% obesity with SM) through modified guidelines of WHO. 22 Obesity, particularly, abdominal obesity may directly contribute to the progress of MS and cardiovascular risk.…”

Section: Obesitymentioning

confidence: 99%

Evaluate the effects of metabolic syndrome in adolescents and children

Jia

Yan

Sun

2020

Frontiers of Nursing

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The metabolic syndrome (MS) in adolescents and children can cause serious consequences that lead researchers to pay efforts to study in such area. Presently, MS definition is still not standardized. Different versions of MS definition have been used by numerous studies, which may be a problem to identify MS and then to predict and prevent clinical diseases. The pediatric literature shows that insulin resistance and obesity might be the key underlying pathophysiology of MS to cause many related diseases. High prevalence of MS is in overweight and obese children and adolescents. This article focuses on such above issues and also effects of MS on two main disease outcomes: cardiovascular disease and type 2 diabetes.

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Indexes of adiposity and body composition in the prediction of metabolic syndrome in obese children and adolescents: Which is the best?

Cited by 25 publications

References 33 publications

Accuracy of Different Indexes of Body Composition and Adiposity in Identifying Metabolic Syndrome in Adult Subjects with Prader-Willi Syndrome

Accuracy of Different Indexes of Body Composition and Adiposity in Identifying Metabolic Syndrome in Adult Subjects with Prader-Willi Syndrome

Progression to hypertension in youth and young adults with type 1 or type 2 diabetes: The SEARCH for Diabetes in Youth Study

Evaluate the effects of metabolic syndrome in adolescents and children

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