Indexing Glomerular Filtration Rate to Body Surface Area: Clinical Consequences

Redal-Baigorri, Belén; Rasmussen, Knud; Heaf, James

doi:10.1002/jcla.21648

Cited by 16 publications

(19 citation statements)

References 23 publications

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“…GFR normalized to BSA is furthermore a strong predictor of development of cardiotoxicity of trastuzumab‐based chemotherapy, independent of original cardiac function (Russo et al ., ). Again BSA has its shortcomings in the extremes of the BSA curves, that is <1·6 m 2 and >2·0 m 2 , as recently shown (Redal‐Baigorri et al ., ). A specific and unresolved normalization problem is related to determination of children's GFR, as discussed in several studies (e.g.…”

Section: Discussionmentioning

confidence: 97%

Body surface area determined by whole‐body CT scanning: need for new formulae?

Villa

Primeau

Hesse

et al. 2015

Clin Physio Funct Imaging

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Calculation of the estimated body surface area (BSA) by body height and weight has been a challenge in the past centuries due to lack of a well-documented gold standard. More recently, available techniques such as 3D laser surface scanning and CT scanning may be expected to quantify the BSA in an easier and more accurate way. This study provides the first comparison between BSA obtained from post-mortem whole-body CT scans and BSA calculated by nine predictive formulae. The sample consisted of 54 male cadavers ranging from 20 to 87 years old. 3D reconstructions were generated from CT scans using Mimics software, and BSA values were automatically extracted from the program. They were compared with nine predictive equations from the literature. Remarkably, close correlations (r > 0·90) were found between BSA values from CT scans and those from the predictive formulae. A mean BSA of the 54 cadavers of 1·84-1·87 m was calculated by all formulae except one, SD values varying between 0·171 and 0·223 m . T-tests revealed significant differences between mean BSA values calculated with CT and three of the formulae. Regression analyses showed intercepts >(0;0) and slopes <1·0 using all predictive equations, with the CT scan determination as gold standard. It is concluded that DuBois and DuBois' equation can be safely used in normal-weight male subjects with high accuracy, but it seems likely that BSA is underestimated in underweight subjects and overestimated in overweight individuals. Creation of new formulae specific for overweight subjects and children may be needed.

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Section: Discussionmentioning

confidence: 97%

Body surface area determined by whole‐body CT scanning: need for new formulae?

Villa

Primeau

Hesse

et al. 2015

Clin Physio Funct Imaging

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“…Normalisation of eGFR to BSA has been criticised previously for different reasons: poor correlation between BSA and mGFR (mL/min), 36 inaccuracy of formulas to calculate BSA 37 and an overestimation of mGFR in paediatric patients, especially in malnourished patients. 38,39 In patients with a BSA <1.60 m 2 , normalised eGFR (mL/min/1.73 m 2 ) overestimated mGFR with a bias of 11.5%. 39 Almost all equations developed in paediatrics include serum creatinine measurement as a variable.…”

Section: Discussionmentioning

confidence: 99%

“…38,39 In patients with a BSA <1.60 m 2 , normalised eGFR (mL/min/1.73 m 2 ) overestimated mGFR with a bias of 11.5%. 39 Almost all equations developed in paediatrics include serum creatinine measurement as a variable. Serum creatinine is highly correlated with muscle mass, and this implies that a relationship between GFR and patient size is already accounted for in these equations.…”

Section: Discussionmentioning

confidence: 99%

Comparison of methods to estimate glomerular filtration rate in paediatric oncology patients

Llanos-Paez

Staatz

Lawson

et al. 2017

J Paediatrics Child Health

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A number of equations were identified that could be used to estimate renal function in paediatric oncology patients; however, none was found to be highly accurate. The Flanders metadata equation and univariate Schwartz performed the best in this study, and we would suggest that these two equations may be used cautiously in paediatric oncology patients for clinical decision making, understanding their limitations.

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“… 5 The calculated value was corrected for each patient's body surface area to arrive at an absolute eGFR value for patients with RA. 6 …”

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confidence: 99%