Regional organizations (ROs), a key component of the global order, have become a significant tool for achieving foreign policy objectives of the member countries. Amidst the prevailing politico-strategic environment, a speckled range of national interests of the regional states and non-regional states has motivated or compelled the states to create, collaborate and participate in the functioning of ROs. India is associated with those ROs that possess objectives convenient in pursuit of its national interests and also identical to its foreign policy targets. In this context, this article argues that India’s policy towards ROs is shaped by the Cold War and post-Cold War developments along with the emerging strategic and security environment in the twenty-first century. These developments have created a divergence or convergence of India’s preferences and beliefs with other countries and have determined its participation in the ROs. It is participating actively in the functioning of ROs in pursuit of its national interests in diverse arenas. The ROs, especially South Asian Association for Regional Cooperation (SAARC), Association of Southeast Asian Nations (ASEAN), Bay of Bengal Initiative for Multi-Sectoral Technical and Economic Cooperation (BIMSTEC), Shanghai Cooperation Organization (SCO) and even European Union (EU) and Quadrilateral Security Dialogue (Quad) are the key instruments for India to achieve the objectives of respective Neighbourhood First Policy (NFP), Look East Policy (LEP), Act East Policy (AEP), Look North Policy (LNP), Connect Central Asia Policy (CCAP) and Indo-Pacific Vision (IPV) frameworks of its foreign policy towards South Asia, Southeast Asia, Central Asia, Indo-Pacific and the globe. Apart from economic, strategic and security cooperation in the regional context, the ROs can help India in bolstering its image and status as a key power in global affairs.