India and the conundrum of booster dose in immunocompromised patients

Chandwar, Kunal; Shah, ChandaniJ; Srivastava, Puja

doi:10.4103/injr.injr_202_21

Cited by 1 publication

(2 citation statements)

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“…2 Vaccine hesitancy in patients with autoimmune rheumatic diseases (AIRD) and specially those on immunosuppressive medications can be disastrous from a public health perspective as they are more likely to have severe infections, transmit it to their household contacts and shed the virus for longer periods and at a higher risk of generating mutant strains compared to healthy individuals. 3 A meta-analysis of seven case-controlled studies conducted by Akiyama S et al showed that the risk of COVID-19 in patients with AIRD was significantly higher than in control patients (OR: 2.19, 95%CI: 1.05-4.58, p = .038). 4 A singlecentre study was conducted which aims to understand the possible reasons for vaccine hesitancy in patients with AIRD and the effectiveness of Specialist counselling on vaccine-hesitant patients to take the vaccine.…”

Section: Introductionmentioning

confidence: 99%

“…1 India’s cumulative COVID vaccination coverage has reached 2,20,64,22,209 doses as of 05/03/2023 due to an efficient vaccine public distribution system and regular awareness campaigns. 2 Vaccine hesitancy in patients with autoimmune rheumatic diseases (AIRD) and specially those on immunosuppressive medications can be disastrous from a public health perspective as they are more likely to have severe infections, transmit it to their household contacts and shed the virus for longer periods and at a higher risk of generating mutant strains compared to healthy individuals. 3 A meta-analysis of seven case-controlled studies conducted by Akiyama S et al showed that the risk of COVID-19 in patients with AIRD was significantly higher than in control patients (OR: 2.19, 95%CI: 1.05–4.58, p = .038).…”

Section: Introductionmentioning

confidence: 99%

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Vaccine Hesitancy Against COVID-19 Vaccines in Patients with Autoimmune Rheumatic Diseases and Effect of Specialist Counselling on Vaccine-hesitant Patients

Chandwar,

Vijayakumaran,

Kishor

et al. 2024

Indian Journal of Rheumatology

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Objectives: To assess causes of vaccine hesitancy to COVID-19 vaccines in patients with autoimmune rheumatic diseases (AIRD). Methods: Study design: We conducted a cross-sectional observational survey-based study of patients attending Rheumatology OPD regarding the reason for vaccine hesitancy, counselled by treating rheumatologists and responses regarding willingness recorded after counselling. Convenience sampling was done by including all adults (>18 years) with AIRD attending rheumatology OPD. Those vaccinated, recently infected (within six weeks), and non-AIRD patients were excluded. The questionnaire included details about patients’ demography, medication and reason for vaccine hesitancy. Statistical analysis was performed using measures of central tendency for quantitative variables and using counts and percentages for qualitative variables. Results: A total of 322 patients participated in the study with a mean age of 40 years (18–76), with 73% (234) females and 27% (88) males. Most patients had RA (40%) followed by SpA (27%), SLE (13%) and were on immunosuppressive medications (95%). A significant proportion of patients (60%) had more than one reason for vaccine hesitancy. Almost 60% of the respondents feared disease flare post-vaccination, while almost half (44.4%) feared vaccine side effects and more than one-third (35%) doubted vaccine efficacy while on immunosuppressive medications. Other causes were the inability to get vaccinated (18%), doubts about vaccine efficacy (15%), and fear of injections (10%). Most patients (91%) expressed vaccine acceptance after specialist counselling. Conclusions: Vaccine hesitancy is multifactorial. Addressing reasons for vaccine hesitancy in patients with AIRD like fear of flare of disease post-vaccination, fear of vaccine side effects and doubts over vaccine efficacy while taking immunosuppressive medications are necessary. Most patients were willing to take vaccine after counselling by a rheumatologist.

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Section: Introductionmentioning

confidence: 99%