Based on the impact of economic security on urban healthy life, the evaluation index system of economic security for healthy life is constructed. The degree of economic security for residents' healthy life in 26 cities of the Yangtze River Delta is comprehensively analyzed by using expert scoring method and linear weighting method. The evaluation results show that there are more cities with higher level of health economic life security in the Yangtze River Delta, which are concentrated in Jiangsu, Zhejiang and Shanghai. With the distance between other cities and Shanghai increasing, the level of economic life security has gradually decreased. The high level of economic foundation of cities in the Yangtze River Delta region provides a good guarantee for the healthy life of the region. At the same time, the imbalance of economic development among cities in the Yangtze River Delta region still exists to a certain extent, and there is still a certain gap in economic development among cities.