Indian-Asian Relationship: mtDNA Reveals More

Barnabás, S.; Joshi, Bheem Dutt; Suresh, C.G.

doi:10.1007/s001140050699

Cited by 6 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Very high frequency of haplogroup M in both these tribes could be due to their small size. Overall, in this study, about 63 per cent of the individuals possessed haplogroup M. This is consistent with the earlier published data (Anderson et al 1981;Passarino et al 1996;Barnabas et al 2000;Roychoudhury et al 2000;Edwin et al 2002;Basu et al 2003). The in situ evolved populations have frequencies comparable with the ancient ethnic groups.…”

Section: Haplogroup M and Nsupporting

confidence: 94%

Genetic admixture studies on four in situ evolved, two migrant and twenty-one ethnic populations of Tamil Nadu, south India

Suhasini

Sonaa²,

Shila³

et al. 2011

J Genet

View full text Add to dashboard Cite

We analysed the genetic structure of ≈ 1000 samples representing 27 ethnic groups settled in Tamil Nadu, south India, derived from two linguistic families (Dravidians and Indo-Europeans) representing four religious groups (Hinduism, Islam, Christianity and Jainism) using 11 mtDNA markers. Out of 27 ethnic groups, four are in situ populations (Anglo-Indian, Labbai Muslim, Nadar Christian and south Indian Jain) and two are migrants (Gypsy and north Indian Jain) from north India to Tamil Nadu, and 21 are native ethnic groups. Six of the markers we used were monomorphic (HaeIII663, HpaI3592, AluI5176, AluI7025, AluI13262, 9-bp deletion) and five markers were polymorphic (DdeI10394, AluI10397, HinfI12308, HincII13259 and HaeIII16517). Haplogroup frequencies, genetic affinities and admixture analysis are based on the genotype data of polymorphic markers observed in these populations. Haplogroup frequencies indicate that various ethnic groups entered Tamil Nadu during different time periods. Genetic affinities and admixture estimates revealed that the ethnic groups possessing advanced knowledge of farming cluster in a branch (C), and could be the late arrived settlers as agriculture, was introduced to this region at about 5 to 3 thousand years ago. In situ ethnic groups appear to have arisen at various times as a result of the prevailing dominant socio-cultural forces. Hierarchical Hindu caste system created many ethnic groups in the history of its existence; some of them became isolated for considerable period of time. Over all, among Tamil ethnic groups, in spite of caste systems' rigidity, built in flexibility in the system in the form of hypergamy and hypogamy had allowed maternal gene flow between them.

show abstract

Section: Haplogroup M and Nsupporting

confidence: 94%

Genetic admixture studies on four in situ evolved, two migrant and twenty-one ethnic populations of Tamil Nadu, south India

Suhasini

Sonaa²,

Shila³

et al. 2011

J Genet

View full text Add to dashboard Cite

show abstract

“…Earlier studies (Barnabas et al 2000;Clark et al 2000;Watkins et al 1999) have also indicated that this 9-bp deletion is extremely infrequent in India. As observed by us earlier (Roychoudhury et al 2000), there is extensive sharing of haplotypes across ethnic groups; one haplotype (00111101010) was modal across all the populations.…”

Section: Figmentioning

confidence: 88%

“…The DNA samples analysed by Quintana-Murci et al (2001) did not include any specific ethnic population of India; it is unclear whether any tribal samples from India were included. Similarly, the studies by Barnabas et al (1996Barnabas et al ( , 2000 were also on samples of mixed ethnicity.…”

Section: Introductionmentioning

confidence: 97%

Genomic structures and population histories of linguistically distinct tribal groups of India

et al. 2001

View full text Add to dashboard Cite

There are various conflicting hypotheses regarding the origins of the tribal groups of India, who belong to three major language groups--Austro-Asiatic, Dravidian and Tibeto-Burman. To test some of the major hypotheses we designed a genetic study in which we sampled tribal populations belonging to all the three language groups. We used a set of autosomal DNA markers, mtDNA restriction-site polymorphisms (RSPs) and mtDNA hypervariable segment-1 (HVS-1) sequence polymorphisms in this study. Using the unlinked autosomal markers we found that there is a fair correspondence between linguistic and genomic affinities among the Indian tribal groups. We reconstructed mtDNA RSP haplotypes and found that there is extensive haplotype sharing among all tribal populations. However, there is very little sharing of mtDNA HVS-1 sequences across populations, and none across language groups. Haplogroup M is ubiquitous, and the subcluster U2i of haplogroup U occurs in a high frequency. Our analyses of haplogroup and HVS-1 sequence data provides evidence in support of the hypothesis that the Austro-Asiatic speakers are the most ancient inhabitants of India. Our data also support the earlier finding that some of the western Eurasian haplogroups found in India may have been present in India prior to the entry of Aryan speakers. However, we do not find compelling evidence to support the theory that haplogroup M was brought into India on an "out of Africa" wave of migration through a southern exit route from Ethiopia. On the contrary, our data raise the possibility that this haplogroup arose in India and was later carried to East Africa from India.

show abstract

“…Over past two decades, allogenic BMT has become the treatment of choice for patients suffering from malignant hematological disorders [acute myeloid leukemia (AML), chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL)], severe cytopenias [myelodysplastic syndrome (MDS) and severe aplastic anemia (AA)] and other non-malignant hematological disorders (a-and b-thalassemia, severe combined immunodeficiency, haemoglobinopathies), etc. [5][6][7][8][9][10][11][12][13][14] Allogenic BMT has been effective in reconstitution of normal haemopoiesis in these patients. The success of this treatment modality is mainly affected by the recurrence of the underlying disease.…”

Section: Introductionmentioning

confidence: 99%

“…This element of uniqueness is employed for various purposes including forensic applications and other molecular tests, which are of clinical relevance. [7][8][9][10][11][12][13][14] One of the utility is in evaluating chimerism in allogenic BMT, which is an important state which develop after engraftment. On the basis of chimerism we can know about the disease relapse, graft rejection or GVHD.…”

Section: Introductionmentioning

confidence: 99%

Use of ApoB3′ hyper variable region in studying mixed chimerism and maternal contamination in North Indian populations

Khan

Phadke

Nityanand

et al. 2004

Journal of Clinical Forensic Medicine

View full text Add to dashboard Cite

Indian-Asian Relationship: mtDNA Reveals More

Cited by 6 publications

References 0 publications

Genetic admixture studies on four in situ evolved, two migrant and twenty-one ethnic populations of Tamil Nadu, south India

Genetic admixture studies on four in situ evolved, two migrant and twenty-one ethnic populations of Tamil Nadu, south India

Genomic structures and population histories of linguistically distinct tribal groups of India

Use of ApoB3′ hyper variable region in studying mixed chimerism and maternal contamination in North Indian populations

Contact Info

Product

Resources

About