Indian Clinical Trials on COVID-19: A Review of Clinical Trials Registry of India (CTRI) (Preprint)

Raju, N. Vasantha; Harinarayana, N.S.

doi:10.2196/preprints.23684

Cited by 12 publications

(16 citation statements)

References 12 publications

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“…Approximately 35% of the registered trials in the CTRI for COVID were for indigenous systems of medicine in India, i.e., AYUSH and associated therapies, and held the majority chunk of the registered studies in the CTRI. An analysis conducted by Raju et al reported a similar proportion (35%) for the AYUSH studies [20]. An early study by Charan et al reported a higher proportion (61.5%) as compared to the present analysis [16].…”

Section: Discussionsupporting

confidence: 61%

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A Systematic Analysis of COVID-19 Clinical Trials Registered in the Clinical Trials Registry of India

Dutta,

Singhal,

Shah

2024

Cureus

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Background: The Clinical Trials Registry -India (CTRI) database is a registry of various trials conducted in India and this study scrutinized the studies registered for COVID-19 from the database to detect patterns in trial design, appraising the target regions of therapies and comprehending the terrain of research endeavors.Method: This was a cross-sectional study that analyzed the registered trials for COVID-19 between March 2020 and September 2023. A trial search was conducted on the CTRI database to include all types of studies registered for COVID-19 with keywords like "COVID" and "coronavirus" and studies conducted on conditions other than COVID-19 were excluded. The data regarding study characteristics were noted under various sections in a preformed proforma.Results: A total of 807 trials were taken for final analysis and there were about 344 prospective and 260 retrospective interventional trials, 35 prospective and 165 retrospective observational studies, and two prospective and one retrospective post-marketing surveillance study. The majority of the studies had duration under 12 months (91%). The maximum number of studies were registered from AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy) and allied therapies (n = 283), with about 104 types of interventions, followed by the drug category having 119 trials registered and about 57 types of interventions. Kabasura Kudineer and yoga in the AYUSH category, molnupiravir, colchicine, and favipiravir in the drug category, and tocilizumab and convalescent plasma among biologics were some common interventions used. The majority of trials did not mention the trial phase and declared it as not applicable (54%), whereas 15% were registered as phase 2 and 13% as phase 3. About 54% of the studies were randomized and randomized parallel-group design (20%) was the most common study design. Only 6% of the trials were post-graduate thesis and the majority of the trials (n = 535) denied sharing their individual participant data. Only 0.86% and 0.61% of the trials were terminated and suspended, respectively, denoting proper design and conduct of the trials. Conclusion:In the CTRI database, the majority of trials were prospective interventional studies, with a predominance of AYUSH therapies and drug interventions. Common interventions included Kabasura Kudineer and yoga in AYUSH, and molnupiravir, colchicine, and favipiravir in drugs. Most studies had durations under 12 months and randomized parallel-group design was the most common study design. The intention to use and promote an indigenous system of medicine looks promising in the absence of any definite therapy. A minute number of registered suspended and terminated trials might be a positive picture of meticulously designed and executed trials even during a pandemic situation in India.

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Section: Discussionsupporting

confidence: 61%

“…A similar study reported Guduchi, ashwagandha, Yashtimadhu, AYUSH-64, AYUSH Kwath, curcumin, and chyawanprash as the common interventions used for COVID [25]. Raju et al reported a lower proportion (25%) of trials of COVID-19 registered with Ayurveda and yoga therapies [20].…”

Section: Discussionmentioning

confidence: 87%

A Systematic Analysis of COVID-19 Clinical Trials Registered in the Clinical Trials Registry of India

Dutta,

Singhal,

Shah

2024

Cureus

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“…The generalization and representativeness of the study findings may also be limited due to the use of convenience sampling and web-based data collection procedures. Although online surveys might only reach a selected population (those who have access to the Internet and are highly educated), they also allow for a fast and easy access to a large population within a wide geographic area (Vasantha Raju & Harinarayana, 2016). We have indeed reached an adequate number of participants, which provided good statistical power and the possibility to compare subgroups.…”

Section: Study Limitationsmentioning

confidence: 93%

Suicide literacy mediates the path from religiosity to suicide stigma among Muslim community adults: Cross-sectional data from four Arab countries

Fekih‐Romdhane

Daher‐Nashif

Stambouli

et al. 2023

Int J Soc Psychiatry

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Background: The majority of research attention has been devoted to the link between religiosity and suicide risk, and a considerable amount of studies has been carried out on how stigma impacts individuals with mental health problems of different kinds. However, the interplay between religiosity, suicide literacy and suicide stigma has seldom been empirically researched, especially quantitatively. We sought through this study to redress the imbalance of research attention by examining the relationship between religiosity and suicide stigma; and the indirect and moderating effects of suicide literacy on this relationship. Method: A cross-sectional web-based survey was conducted among Arab-Muslim adults originating from four Arab countries (Egypt: N = 1029, Kuwait: N = 2182, Lebanon N = 781, Tunisia N = 2343; Total sample: N = 6335). The outcome measures included the Arabic Religiosity Scale which taps into variation in the degree of religiosity, the Stigma of Suicide Scale-short form to the solicit degree of stigma related to suicide, and the Literacy of Suicide Scale explores knowledge and understanding of suicide. Results: Our Mediation analyses findings showed that literacy of suicide partially mediated the association between religiosity and stigmatizing attitude toward suicide. Higher religiosity was significantly associated with less literacy of suicide; higher literacy of suicide was significantly associated with less stigma of suicide. Finally, higher religiosity was directly and significantly associated with more stigmatization attitude toward suicide. Conclusion: We contribute the literature by showing, for the first time, that suicide literacy plays a mediating role in the association between religiosity and suicide stigma in a sample of Arab-Muslim community adults. This preliminarily suggests that the effects of religiosity on suicide stigma can be modifiable through improving suicide literacy. This implies that interventions targeting highly religious individuals should pay dual attention to increasing suicide literacy and lowering suicide stigma.

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“…We conducted a cross-sectional online pilot study using online Google forms, which is a freely available cloud-based data management tool for online surveys (Vasantha Raju & Harinarayana, 2016). As the study was conducted during SARS-CoV 2 pandemic, digital research was considered as the most appropriate methodology (Favilla & Pita, 2020).…”

Section: Methodsmentioning

confidence: 99%

Views of South Asian Physicians on Climate Related Health Effects: A Multinational Cross-Sectional Pilot Study

Zulfiqar¹,

Jawaid²,

Khan³

et al. 2023

AJCC

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Background: South Asian populations are vulnerable to poor health outcomes associated with climate due to the region's complex topography, poverty, lack of education, and population density. Physicians, being highly trusted members of society, can help mitigate climate change effects in their countries. Objectives: The present study assessed perceptions of physicians from four South Asian countries (Bangladesh, Bhutan, India, and Pakistan). We hypothesized that physicians from these countries will be aware and knowledgeable about health effects of climate change. Methods: We conducted a cross-sectional online survey of physicians between March and July 2022. Data of 201 physicians was analyzed using the Kruskal-Wallis test and Dunn's post hoc method. Results: Physicians from four South Asian countries were attuned to the health risks associated with climate change. A majority of physicians (86.6%) believed that climate change would make health conditions in their countries more severe or frequent (Bangladesh 83.3%; Bhutan 70%; India 91% and Pakistan 90.8%). The most common health effect related to climate change was illnesses related to reduced outdoor air quality (54.3%). Common barriers to discuss climate change with patients from all four countries were physicians' lack of knowledge (strongly agree, 13.8%; agree 47.7%) in how to approach the issue with patients, lack of time (strongly agree, 12%; agree, 48%) and their perception that patients were How to cite this paper: Zulfiqar, T.

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Indian Clinical Trials on COVID-19: A Review of Clinical Trials Registry of India (CTRI) (Preprint)

Cited by 12 publications

References 12 publications

A Systematic Analysis of COVID-19 Clinical Trials Registered in the Clinical Trials Registry of India

A Systematic Analysis of COVID-19 Clinical Trials Registered in the Clinical Trials Registry of India

Suicide literacy mediates the path from religiosity to suicide stigma among Muslim community adults: Cross-sectional data from four Arab countries

Views of South Asian Physicians on Climate Related Health Effects: A Multinational Cross-Sectional Pilot Study

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