Indian diabetes risk score according to menopausal status in Asian Indian women: The Santiniketan Women study

Ghosh, Arnab; Bhagat, Minakshi

doi:10.1111/j.1753-0407.2009.00035.x

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…The Santiniketan Women Study[39] was done in West Bengal to evaluate the use MDRF-IDRS with respect to menopausal status in Asian Indian women. This study revealed that of the 102 pre-menopausal women, 9% had high IDRS, whereas, of the 34 post-menopausal women, 38% had high IDRS (χ 2 = 16.13; P < 0.001).…”

Section: Idrs and Post-menopausal Womenmentioning

confidence: 99%

Expanding role of the Madras Diabetes Research Foundation - Indian Diabetes Risk Score in clinical practice

Mohan

Anbalagan

2013

Indian J Endocr Metab

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The Indian Diabetes Risk Score was initially developed by the Madras Diabetes Research Foundation (MDRF-IDRS) to help detect undiagnosed Type 2 diabetes (T2DM) in the community. Soon it was found that the MDRF-IDRS could also help to predict incident diabetes, metabolic syndrome, coronary artery disease (CAD), non-alcoholic fatty liver disease as well as sleep disorders in the community. It helps to differentiate T2DM from non-T2DM. Finally, it also helps to identify those with CAD, peripheral vascular disease and neuropathy among those with T2DM. Thus, the MDRF-IDRS is a simple, virtually ‘no cost’ tool which is useful in several clinical and epidemiological settings.

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Section: Idrs and Post-menopausal Womenmentioning

confidence: 99%

Expanding role of the Madras Diabetes Research Foundation - Indian Diabetes Risk Score in clinical practice

Mohan

Anbalagan

2013

Indian J Endocr Metab

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“…Post-menopausal women are believed to be more susceptible to T2D due to their greater percentage of body fat and intra-abdominal visceral fat 26 . In the present study, an increased risk of T2D was found among normal weight menopausal women (OR, 2.61; 95% CI, 1.17–5.80).…”

Section: Discussionmentioning

confidence: 99%

Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women

Nfor

Lee

et al. 2018

Sci Rep

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CDKAL1 rs10946398 is a type 2 diabetes (T2D)-associated variant. It is a new body mass index (BMI)-associated variant in Asian populations. We investigated the association between rs10946398 and T2D among 9908 participants aged 30–70 years based on BMI: normal weight; 18.5 ≤ BMI < 24 kg/m2, overweight; 24 ≤ BMI < 27 kg/m2, and obesity; BMI ≥27 kg/m2. The CC genotype conferred a higher risk of T2D than the CA genotype. The odds ratios (ORs) were 1.83; 95% confidence interval (CI) 1.49–2.26 and 1.20; 95% CI 1.02–1.40, respectively. The C allele was the significant risk allele compared with A allele (OR = 1.32; 95% CI 1.19–1.47). For normal, overweight and obese participants with CC genotype, the ORs were respectively 1.69; 95% CI 1.02–2.81, 2.34; 95% CI 1.50–3.66, and 1.58; 95% CI 1.02–2.45 among men and 1.22; 95% CI 0.67–2.22, 2.42; 95% CI 1.30–4.52, and 2.3; 95% CI 1.19–4.50 among women. The C allele ORs were higher in obese and overweight women. In conclusion, the rs10946398 CC/CA genotypes, as well as the C allele increased the risk of T2D. The ORs were higher in women who were overweight and obese than in those with normal weight. Nonetheless, significant results were prominent only among those with CC genotype and C allele.

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“…60 Post-menopausal Asian Indian women have been previously reported to be more susceptible to T2DM and CVD than premenopausal women. 61 Bhagat et al 62 have conducted a crosssectional study on 214 pre-menopausal and post-menopausual women from West Bengal (East India) and showed that phenotypic variations explained by a clustering of cardiometabolic risk factors was 72.9% and 90.4% in pre-menopausal and post-menopausal women, respectively. A study of urban slum post-menopausal women (n ¼ 278) from North India revealed high prevalence of obesity and dysmetabolic state.…”

Section: Dyslipidemiamentioning

confidence: 99%

Overweight, obesity and related non-communicable diseases in Asian Indian girls and women

et al. 2013

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The prevalence of obesity is rising globally and in India. Overweight, obesity and related diseases need to be delineated in Asian Indian women. A literature search was done using key words like 'obesity', 'Asian Indian women', 'body fat distribution', 'type 2 diabetes', 'fertility', 'polycystic ovarian disease', metabolic syndrome', 'cardiovascular disease', 'non-alcoholic fatty liver disease', 'gender', 'sex' and 'prevalence' up to September 2012 in Pubmed and Google Scholar search engines. This review highlights the Asian Indian body composition with regards to obesity and provides a collated perspective of gender-specific prevalence of the co-morbidities. Recent data show that women (range of prevalence of overweight and obesity from different studies 15-61%) have higher prevalence of overweight and obesity as compared with men (range of prevalence of overweight and obesity from different studies 12-54%) in India and that obesity is increasing in the youth. The prevalence of overweight and obesity in both men and women steeply rose in a Punjabi community from Jaipur. Importantly, prevalence of abdominal obesity has been consistently higher in women than in men. The lowest prevalence (6.0%) of type 2 diabetes mellitus in women is reported from South India (rural Andhra Pradesh; 2006) and the highest (14.0%) by the National Urban Diabetes Survey (2001). Although the clustering of cardiovascular disease risk factors was generally high, it increased further in post-menopausal women. There are a number of factors that predispose Indian women to obesity; sedentary behaviour, imbalanced diets, sequential and additive postpartum weight gain and further decrease in physical activity during this period and cultural issues. In view of these data, preventive measures should be specifically targeted to Indian women.

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Indian diabetes risk score according to menopausal status in Asian Indian women: The Santiniketan Women study

Cited by 7 publications

References 3 publications

Expanding role of the Madras Diabetes Research Foundation - Indian Diabetes Risk Score in clinical practice

Expanding role of the Madras Diabetes Research Foundation - Indian Diabetes Risk Score in clinical practice

Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women

Overweight, obesity and related non-communicable diseases in Asian Indian girls and women

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