Indian Herbal Medicine for Cancer Therapy and Prevention

Arora, Rajesh; Malhotra, Poonam; Chawla, Roshani; Gupta, Deepesh; Sharma, Rakesh; Baliga, Manjeshwar Shrinath

doi:10.1201/b10330-39

Cited by 4 publications

(4 citation statements)

References 93 publications

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“…Moreover, due to difficult hilly terrain, modern cancer treatment facilities are few and difficult to access. It often results in the inclination of the local people to opt for traditional medicine for the prevention and treatment of cancer [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Use of complementary and alternative medicine among patients with cancer in a sub-Himalayan state in India: An exploratory study

Pandey

Pasricha

Joseph

et al. 2021

Journal of Ayurveda and Integrative Medicine

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Background The use of complementary and alternative medicine (CAM) is widespread among cancer patients in India. Objective The present study elucidated usage patterns of CAM and the factors responsible for its adoption among the patients with cancer, and the therapeutic impact of CAM. Materials and methods This was a questionnaire-based study, conducted among patients with cancer in a tertiary care hospital in a sub-Himalayan city. Data were analyzed using statistical methods. Results A total of 2614 patients with cancer were included. Almost half of the patients (n = 1208, 46.2%) reported to have been treated with CAM. Breast cancer (n = 274, 23.0%) was most prevalent with majority at advanced stages. Ayurveda (n = 428, 35.9%) Yoga/Naturopathy (n = 381, 32.0%) Homeopathy (n = 143, 12.0%) and Unani (n = 71, 5.9%) were used commonly. Among CAM users, 85.0% (n = 1012) of patients used CAM as the sole method of treatment, while 58.9% (n = 702) patients reported initial symptomatic benefit. Conclusion Using CAM benefitted a significant number of patients with cancer. However, there is an urgent need to integrate CAM with modern system of medicine.

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Section: Introductionmentioning

confidence: 99%

Use of complementary and alternative medicine among patients with cancer in a sub-Himalayan state in India: An exploratory study

Pandey

Pasricha

Joseph

et al. 2021

Journal of Ayurveda and Integrative Medicine

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“…( Shah et al, 2021 ). A critically endangered plant, Podophyllum hexandrum of the family Berberidaceae rhizomes, processes several lignans which show anticancer activities ( Arora et al, 2010 ). Various Podophyllotoxin derivatives have been synthesized to address drawbacks like systemic toxicity, drug resistance, and limited bioavailability (H. Fan et al, 2021 ).…”

Section: Anticancer Phytochemical Compounds and Their Mechanism Of Ac...mentioning

confidence: 99%

Biosynthesis of anticancer phytochemical compounds and their chemistry

Dogra

Kumar

2023

Front. Pharmacol.

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Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, and metastatic malignancies have increased. Plant-derived phytochemical compounds target different oncogenes, tumor suppressor genes, protein channels, immune cells, protein channels, and pumps, which have attracted much attention for treating cancer in preclinical studies. Despite the anticancer capabilities of these phytochemical compounds, systemic toxicity, medication resistance, and limited absorption remain more significant obstacles in clinical trials. Therefore, drug combinations of new phytochemical compounds, phytonanomedicine, semi-synthetic, and synthetic analogs should be considered to supplement the existing cancer therapies. It is also crucial to consider different strategies for increased production of phytochemical bioactive substances. The primary goal of this review is to highlight several bioactive anticancer phytochemical compounds found in plants, preclinical research, their synthetic and semi-synthetic analogs, and clinical trials. Additionally, biotechnological and metabolic engineering strategies are explored to enhance the production of bioactive phytochemical compounds. Ligands and their interactions with their putative targets are also explored through molecular docking studies. Therefore, emphasis is given to gathering comprehensive data regarding modern biotechnology, metabolic engineering, molecular biology, and in silico tools.

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“…9 The patients with cancer prefer CAM due to the risk of death, surgery-associated long-term morbidity, and adverse effects associated with conventional therapy. 10 Despite advances in diagnosis and management, around 57% patients with BC are diagnosed in the locally advanced stage. 2 The CAM use is associated with delays in presentation and diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…9 The patients with cancer prefer CAM due to the risk of death, surgery-associated long-term morbidity, and adverse effects associated with conventional therapy. 10…”

Section: Introductionmentioning

confidence: 99%

Complementary and Alternative Medicine Use and Its Impact on the Delayed Presentation and Advanced Stage of Breast Cancer in Newly Diagnosed Indian Women

Pawar,

Diwan,

Mahobia

2024

Indian J Med Paediatr Oncol

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Introduction Complementary and alternate medicine (CAM) use is highly prevalent among Indian cancer patients. However, such studies from the perspective of Indian patients with breast cancer (BC) are lacking. Objective The aim of this study was to evaluate the incidence of CAM use and its impact on the presentation of patients with BC. Materials and Methods This retrospective study was performed in the Department of Radiation Oncology over a period of 6 months (January to June 2019) and involved review of hospital-record of 229 newly-diagnosed patients with BC. Univariate and multivariate binary logistic regression analysis was done to evaluate the association of CAM use with the BC stage and various clinicodemographic variables. Results Of 229 patients, 96 (41.92%) used CAM. The CAM use was significantly associated with rural residence (odds ratio [OR]: 4.092; 95% confidence interval [CI]: 2.27–7.35), illiteracy (OR: 6.417; 95% CI: 1.83–22.45), delayed presentation by 3 to 6 (OR: 12.964; 95% CI: 2.94–57.00) and more than 6 months (OR: 40.667; 95% CI: 9.26–178.46), and advanced stage at diagnosis (OR: 10.786; 95% CI: 5.15–22.58). Similarly, advanced stage at diagnosis was significantly associated with rural residence (OR: 2.78; 95% CI: 1.59–4.84), illiteracy (OR: 7.20; 95% CI: 1.86–22.79,), and delayed presentation by 3 to 6 (OR: 6.41; 95% CI: 2.81–14.61) and more than 6 months (OR: 17.55; 95% CI: 7.26–42.45). Conclusions CAM use was highly prevalent among the patients with BC and significantly associated with advanced stage at diagnosis. Moreover, both CAM use and advanced stage at diagnosis were significantly associated with rural residence, low educational status, and delayed presentation.

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Indian Herbal Medicine for Cancer Therapy and Prevention

Cited by 4 publications

References 93 publications

Use of complementary and alternative medicine among patients with cancer in a sub-Himalayan state in India: An exploratory study

Use of complementary and alternative medicine among patients with cancer in a sub-Himalayan state in India: An exploratory study

Biosynthesis of anticancer phytochemical compounds and their chemistry

Complementary and Alternative Medicine Use and Its Impact on the Delayed Presentation and Advanced Stage of Breast Cancer in Newly Diagnosed Indian Women

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