Indicaciones actuales de la oxigenoterapia hiperbárica

Desola, Jordi

doi:10.1016/s1134-2072(09)72308-4

Cited by 5 publications

(3 citation statements)

References 91 publications

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“…The involvement of CBs in the control of metabolic homeostasis is also supported by clinical data: type 2 diabetes patients who underwent functional suppression of CB activity (via hyperbaric oxygen therapy) showed improved glucose tolerance and significantly reduced plasma glucose levels [6][7][8][9][10]. It has also been reported that oxygen therapy significantly decreases systolic blood pressure in both type 2 diabetic and hypertensive patients [11] and improves insulin sensitivity in diabetic patients [8], without changing insulin levels [7]. CBs have recently been considered a novel target for regulating peripheral insulin sensitivity.…”

Section: Introductionmentioning

confidence: 80%

“…We demonstrated that insulin stimulates the peripheral chemoreceptors in CBs, crucial for triggering CB-induced sympathoadrenal overactivity, contributing to the vicious cycle of insulin resistance (IR) and hypertension seen in metabolic disorders [5]. The involvement of CBs in the control of metabolic homeostasis is also supported by clinical data: type 2 diabetes patients who underwent functional suppression of CB activity (via hyperbaric oxygen therapy) showed improved glucose tolerance and significantly reduced plasma glucose levels [6][7][8][9][10]. It has also been reported that oxygen therapy significantly decreases systolic blood pressure in both type 2 diabetic and hypertensive patients [11] and improves insulin sensitivity in diabetic patients [8], without changing insulin levels [7].…”

Section: Introductionmentioning

confidence: 83%

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Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver

et al. 2016

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Aims/hypothesis We recently described that carotid body (CB) over-activation is involved in the aetiology of insulin resistance and arterial hypertension in animal models of the metabolic syndrome. Additionally, we have demonstrated that CB activity is increased in animal models of insulin resistance, and that carotid sinus nerve (CSN) resection prevents the development of insulin resistance and arterial hypertension induced by highenergy diets. Here, we tested whether the functional abolition of CB by CSN transection would reverse pre-established insulin resistance, dyslipidaemia, obesity, autonomic dysfunction and hypertension in animal models of the metabolic syndrome. The effect of CSN resection on insulin signalling pathways and tissue-specific glucose uptake was evaluated in skeletal muscle, adipose tissue and liver. Methods Experiments were performed in male Wistar rats submitted to two high-energy diets: a high-fat diet, representing a model of insulin resistance, hypertension and obesity, and a high-sucrose diet, representing a lean model of insulin resistance and hypertension. Half of each group was submitted to chronic bilateral resection of the CSN. Age-matched control rats were also used. Results CSN resection normalised systemic sympathetic nervous system activity and reversed weight gain induced by high-energy diets. It also normalised plasma glucose and insulin levels, insulin sensitivity lipid profile, arterial pressure and endothelial function by improving glucose uptake by the liver and perienteric adipose tissue. Conclusions/interpretation We concluded that functional abolition of CB activity restores insulin sensitivity and glucose homeostasis by positively affecting insulin signalling pathways in visceral adipose tissue and liver.

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Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 83%

Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver

et al. 2016

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“…O ar normal tem 16% de oxigênio e a terapia em câmara com oxigênio hiperbárico usa uma porcentagem maior que o normal, chegando a 100% de oxigênio. difundida no meio médico (Desola et al (1998); Covarrubias;Rodriguez (2002) PSC-HCFMUSP (1993)).…”

Section: Introductionunclassified