Indicaciones y resultados a largo plazo de los trasplantes de órganos sólidos. Calidad de vida en pacientes trasplantados

Ruiz, D. Daga; Aguirre, C. Fernández; González, F. Segura; Ruiz, M. Carballo

doi:10.1016/s0210-5691(08)70957-4

Cited by 12 publications

(3 citation statements)

References 22 publications

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“…During the second half of the 20th century, organ transplantation revolutionized the medicine field, becoming a daily activity in clinical practice . In the European Union, approximately 30,000 organ transplantations are performed in a year, and with 4000 of these interventions being carried out in Spain .…”

mentioning

confidence: 99%

Efficacy of hydrodynamic interleukin 10 gene transfer in human liver segments with interest in transplantation

Sendra

Matas

Ortí³

et al. 2016

Liver Transpl

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Different diseases lead, during their advanced stages, to chronic or acute liver failure, whose unique treatment consists in organ transplantation. The success of intervention is limited by host immune response and graft rejection. The use of immunosuppressant drugs generally improve organ transplantation, but they cannot completely solve the problem. Also, their management is delicate, especially during the early stages of treatment. Thus, new tools to set an efficient modulation of immune response are required. The local expression of interleukin (IL) 10 protein in transplanted livers mediated by hydrodynamic gene transfer could improve the organ acceptance by the host because it presents the natural ability to modulate the immune response at different levels. In the organ transplantation scenario, IL10 has already demonstrated positive effects on graft tolerance. Hydrodynamic gene transfer has been proven to be safe and therapeutically efficient in animal models and could be easily moved to the clinic. In the present work, we evaluated efficacy of human IL10 gene transfer in human liver segments and the tissue natural barriers for gene entry into the cell, employing gold nanoparticles. In conclusion, the present work shows for the first time that hydrodynamic IL10 gene transfer to human liver segments ex vivo efficiently delivers a human gene into the cells. Indexes of tissue protein expression achieved could mediate local pharmacological effects with interest in controlling the immune response triggered after liver transplantation. On the other hand, the ultrastructural study suggests that the solubilized plasmid could access the hepatocyte in a passive manner mediated by the hydric flow and that an active mechanism of transportation could facilitate its entry into the nucleus.

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confidence: 99%

Efficacy of hydrodynamic interleukin 10 gene transfer in human liver segments with interest in transplantation

Sendra

Matas

Ortí³

et al. 2016

Liver Transpl

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“…La cirugía de trasplante conforma uno de los grandes avances médicos de los últimos tiempos, dado su papel en la recuperación de salud y en el fomento de la calidad de vida en personas que padecen enfermedades crónicas [1][2][3][4] .…”

Section: Introductionunclassified

Aspectos psicosociales en pacientes candidatos a trasplante de órganos

Ibáñez-López

Méndez-Méndez

Concha-Gónzález

et al. 2021

Duazary

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Este estudio analiza las variables psicosociales implicadas en el proceso de trasplante de órganos y plantea las posibles contribuciones de la psicología clínica en su abordaje. Se trata de un estudio descriptivo-transversal con muestra no probabilística intencional de N=64 (51 hombres y 13 mujeres), con edades comprendidas entre 37 y 66 años (Media=58,17; Desviación Típica=6,038). La evaluación se realiza mediante la entrevista clínica, la aplicación de la Escala de Ansiedad y Depresión Hospitalaria de Zimong y Shaith y del Mini-Examen del Estado Mental de Folstein y colaboradores. Se encuentra que entre el 56-68% de los pacientes tiene conciencia de la necesidad de mantener hábitos saludables. Un 37,5% del grupo de trasplante hepático no cumple abstinencia alcohólica superior a 6 meses. Más de la mitad de los candidatos tienen antecedentes en salud mental y aproximadamente el 20% presenta sintomatología clínica. Entre el 62-81% está motivado para la intervención. La influencia de los factores psicosociales en la evolución y el pronóstico de los trasplantes muestra la necesidad de fomentar la participación del psicólogo clínico en la evaluación y en el desarrollo de intervenciones adecuadas a las necesidades específicas de cada fase, favoreciendo la atención sanitaria integral durante todo el proceso.

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“…The most frequently transplanted organs include the kidney, liver, heart, and lung 1. In recent decades, the rate of solid organ transplantation has significantly increased worldwide 2,3. In addition, improved organ allocation, donor selection, surgical techniques, and technology; refined corticosteroid and immunosuppressive regimens; and better diagnosis and treatment of complications have contributed to increasing the success rate of these transplants 4,5…”

Section: Introductionmentioning

confidence: 99%

<p>National Trends In Kidney, Heart And Liver Transplants Among Patients With And Without Chronic Obstructive Pulmonary Disease In Spain (2001–2015)</p>

Miguel-Díez¹,

Jiménez‐García²,

Hernández-Barrera³

et al. 2019

COPD

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BackgroundTo describe trends and outcomes during admission for solid organ transplants, excluding lungs, in people with or without COPD in Spain (2001–2015).MethodsWe used national hospital discharge data to select all hospital admissions for kidney, heart and liver transplants. We estimated admission rates stratified by COPD status. We analyzed the Charlson Comorbidity Index, therapeutic procedures and outcomes.ResultsWe identified 52,020 admissions (33,293 for kidney transplant, 3,937 for heart transplant and 14,790 for liver transplant). Patients with COPD accounted for 2.5%, 4.2% and 3.5% of kidney, heart and liver transplant patients, respectively. The number of kidney and liver transplants increased among COPD patients over the study period, whereas the number of heart transplants remained stable. In all cases, COPD patients were significantly older and had more coexisting medical conditions than those without COPD. Among patients who underwent a kidney transplant, there were no significant differences in the clinical characteristics analyzed between the groups, but the overall in-hospital mortality (IHM) rate was significantly higher in COPD patients than in those without COPD (2.22% vs 0.58%, p=0.008). There were no differences for any of the study variables or for the IHM rate in patients who underwent a heart transplant (14.63% in both groups). Among patients who underwent a liver transplant, COPD patients had lower prevalences of infection and complications than those without COPD. The IHM rate was also significantly lower in COPD patients than in non-COPD controls who underwent a liver transplant (4.07% vs 8.91%, p=0.002).ConclusionCOPD prevalence in patients undergoing renal, heart and liver transplants is lower than it has been described in the general population. However, we did not find differences in the clinical characteristics analyzed between COPD and non-COPD patients. Furthermore, the IHM rate was only higher in COPD patients who underwent a kidney transplant but not in those undergoing a heart or liver transplant.

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Indicaciones y resultados a largo plazo de los trasplantes de órganos sólidos. Calidad de vida en pacientes trasplantados

Cited by 12 publications

References 22 publications

Efficacy of hydrodynamic interleukin 10 gene transfer in human liver segments with interest in transplantation

Efficacy of hydrodynamic interleukin 10 gene transfer in human liver segments with interest in transplantation

Aspectos psicosociales en pacientes candidatos a trasplante de órganos

<p>National Trends In Kidney, Heart And Liver Transplants Among Patients With And Without Chronic Obstructive Pulmonary Disease In Spain (2001–2015)</p>

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