Indication for pancreatic enzyme substitution following gastric resection

Friess, Helmut; Tempia-Caliera, Adrien A.; Cammerer, Gregor; Büchler, M.

doi:10.1159/000055891

Cited by 17 publications

(23 citation statements)

References 31 publications

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“…A decrease in the excretion of bicarbonate and exocrine pancreatic enzymes, such as chymotrypsin, lipase, and amylase, has been observed (11,15). These changes were very significant.…”

Section: Resultsmentioning

confidence: 96%

“…Bariatric surgery changes the taste, meal pattern and duration, gastric emptying and intestinal transit time, gut hormone release, bile acid metabolism, and microbiota (25). Frequently reported symptoms include diarrhea, steatorrhea, loss of appetite, and increased bowel movements (3,11,15). Dib et al (8) observed morphological changes in the gut manifested by a decrease in villus length, crypt depth, and mucosa thickness in the duodenum and proximal jejunum accompanied by their increase in the distal jejunum and ileum.…”

Section: Resultsmentioning

confidence: 99%

“…Dib et al (8) observed morphological changes in the gut manifested by a decrease in villus length, crypt depth, and mucosa thickness in the duodenum and proximal jejunum accompanied by their increase in the distal jejunum and ileum. Various hypotheses have been proposed to explain the gastrointestinal symptoms, attributing them to bacterial colonization of the gut, low-calorie intake due to changed eating habits, and pancreatic insufficiency (9,11,25).…”

Section: Resultsmentioning

confidence: 99%

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Effect of fundectomy, antrectomy and gastrectomy on pancreatic and brush border enzyme activity in rats

Kapica¹,

Puzio²

2018

Medycyna Weterynaryjna

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The aim of our study was to investigate the possible effects of the removal of different parts of the stomach (fundectomy, antrectomy, gastrectomy) on the total protein content and enzyme activity in the pancreas and the brush border of the intestinal mucosa. Twenty-four 2.5-month-old male Wistar rats were divided into four groups: sham-operated animals (SHO) and those subjected to gastrectomy (Gx), fundectomy (Fx), and antrectomy (ANT). After a six-week experiment, the rats were sacrificed, and blood was collected for further gastrin analysis in serum. Samples of the pancreas, duodenum, and jejunum (proximal part in 25% of length, middle part in 50% of length, and distal part in 75% of length) were collected to determine the total protein content and enzyme activity. The rats subjected to fundectomy, antrectomy and gastrectomy showed an increased total protein content and enzyme activity (amylase, trypsin) in pancreatic tissue. They exhibited an increase in the total protein content in the homogenates of the mucosa of the proximal, middle and distal jejunum, compared to the control, and a statistical increase in maltase activity. Compared with the control group, the rats subjected to Fx and ANT showed a decreased sucrase activity in the homogenates of the mucosa of the duodenum and of the proximal, middle and distal jejunum. In the gastrectomized rats, there was a statistically significant increase in the total protein content in the homogenates of the mucosa of the jejunum, compared to the control, while the activities of lactase and sucrase were decreased. There was a statistically significant increase in the gastrin level in all experimental groups (Fx, ANT, Gx). We suggest that surgical removal of a part of the stomach radically changes the level of hormones that determine many functions of the organism. Hormonal changes may have an impact on the pancreas and the activity of brush border enzymes. .

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“…A decrease in the excretion of bicarbonate and exocrine pancreatic enzymes, such as chymotrypsin, lipase, and amylase, has been observed (11,15). These changes were very significant.…”

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of fundectomy, antrectomy and gastrectomy on pancreatic and brush border enzyme activity in rats

Kapica¹,

Puzio²

2018

Medycyna Weterynaryjna

View full text Add to dashboard Cite

show abstract

“…No differences in individual symptom scores were reported. Conclusion: Gastrointestinal symptoms such as steatorrhea, bloating, and dumping syndrome may be related to exocrine pancre-due to a loss of stimulation of the pancreas, and a rapid upper intestinal transit time [4,5] . Frequently observed symptoms such as diarrhea and steatorrhea have all been described in relation to pancreatic insufficiency [8] .…”

Section: Exocrine Pancreatic Insufficiency · Gastric Cancer · Gastrecmentioning

confidence: 99%

“…In up to 90% of patients following gastrectomy, a wide array of gastro-intestinal symptoms and complications is reported [3,4] . A few frequently observed symptoms are diarrhea, steatorrhea, flatulence, loss of appetite, and increased bowel movements, and these symptoms occur most often in combination with each other and may finally result in malnutrition and weight loss [5,6] . Although gastric resections have been performed since 1881, the exact cause of these post-surgical symptoms is still unclear [7] .…”

Section: Introductionmentioning

confidence: 99%