Indication of a genetic basis of stereotypies in laboratory-bred bank voles (Clethrionomys glareolus)

Schoenecker, B; Heller, Knud Erik

doi:10.1016/s0168-1591(00)00114-3

Cited by 42 publications

(20 citation statements)

References 44 publications

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“…Schoenecker & Heller 2000;Presti et al 2003) or post mortem histology, for instance for dendritic branching or metabolic activity (via cytochrome oxidase staining; e.g. McBride & Hemmings 2005;Lewis et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Correlates of birth origin effects on the development of stereotypic behaviour in striped mice, Rhabdomys

2011

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The behaviour and physiology of wild animals born in zoos, laboratories and breeding centres can differ substantially from that of their wild-caught (WC) conspecifics. For instance, captive-born (CB) animals are typically more prone to developing abnormal repetitive behaviours. In captive striped mice, Rhabdomys, we first confirmed that birth origin predicted the emergence of stereotypic behaviour (SB), with CB mice being most at risk. Second, to investigate correlates of this birth origin effect, we tested WC and CB striped mice in behavioural tasks to quantify fear/anxiety, activity and perseveration, and measured faecal corticosterone to assess physiological stress. WC mice proved more fearful and less active than CB animals, and had higher levels of faecal corticosterone metabolites. These effects, however, were unrelated to SB. WC mice were also less perseverative and more behaviourally flexible than CB animals, traits that covary with SB. Third, a retrospective analysis of laboratory records showed that SB incidence was significantly lower in adult-caught than juvenile-caught striped mice, with juvenile males being the most severely affected by early removal from the wild. In conclusion, our results indicate that adult, but not juvenile WC striped mice are typically protected against SB development in captivity, despite having poorer welfare than their CB conspecifics. They also reveal profound behavioural changes in CB mice, changes suggestive of altered forebrain function, a hypothesis now needing direct testing. Ó

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Section: Discussionmentioning

confidence: 99%

Correlates of birth origin effects on the development of stereotypic behaviour in striped mice, Rhabdomys

2011

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“…Although more attention has focused on environmental influences, the role of genetics in stereotypy cannot be overlooked. Stereotypy is heritable in bank voles (Clethrionomys glareolus) (Schoenecker and Heller, 2000) and African striped mice (Rhabdomys pumilio) (Schwaibold and Pillay, 2001), similarly, the importance of genetic transmission has also been noted in fur animals, such as mink (Hansen, 1993). Smith (1984) suggests that the occurrence of stereotypes in thoroughbred racehorses has a genetic origin.…”

Section: Introductionmentioning

confidence: 99%

Correlation analysis between single nucleotide polymorphism of DRD1 gene and stereotyped behavior of blue fox

Liu¹,

Ren²,

Ba³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study was performed to investigate the correlation between stereotyped behavior of the blue fox and single nucleotide polymorphisms (SNPs) of the DRD1 gene. We choose the DRD1 gene as a major gene for investigating the correlation of gene polymorphism and self-biting disease by means of direct sequencing. Part of the DRD1 gene exon of the blue fox was cloned; the length of the whole sequence was 864 bp. Four SNPs were detected and analyzed by the chi-square analysis; the results showed that the gene polymorphism of T206C in the DRD1 gene had a significant correlation with self-biting (P < 0.01). Therefore, marker-assistant selection on self-biting of blue foxes using these SNPs can be applied to select healthy individuals.

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“…Pedigree studies also suggest the involvement of genetic factors, although the mode of inheritance has not been determined (Vecchiotti and Galanti, 1986). Genetic evidence in other animal stereotypies has been established, including examples such as bank voles (Schoenecker and Heller, 2000) and compulsive dogs (Dodman et al, 2010). Stress, gastric discomfort and frustration caused by stall restrictions and early weaning (Nicol et al, 2002;Latham and Mason, 2008;Hothersall and Nicol, 2009) have been suggested as additional risk factors for equine crib-biting.…”

Section: Introductionmentioning

confidence: 99%

Exploration of known stereotypic behaviour-related candidate genes in equine crib-biting

Hemmann

Ahonen

Raekallio

et al. 2014

Animal

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Crib-biting in horses is a stereotypic oral behaviour. Genetic susceptibility has been suggested on a causal basis, together with environmental factors such as stress, gastric discomfort and frustration caused by stall restrictions. This study aimed to test the associations of known or suspected stereotypic genes with equine crib-biting, including Ghrelin, Ghrelin receptor, Leptin, Dopamine receptor, μ-opioid receptor, N-cadherin, Serotonin receptor and Semaphorin. We conducted a candidate gene study with a case-control design, including 98 crib-biting and 135 control horses of two breeds, Finnhorses and half-breds. Detailed phenotypic information on crib-biting behaviour was surveyed through an owner-completed questionnaire. Control horses were more than 10 years old and without a history of crib-biting. Single nucleotide polymorphisms flanking the candidate genes were genotyped using either Sanger sequencing or Taqman assays. According to the survey, the affected horses started crib-biting at a young age, had exhibited crib-biting for more than a year, and expressed the behaviour after feeding or when stressed. Comparison of allele frequencies between the cases and controls for each breed separately did not provide evidence of an association at any of the tested loci. These results suggest that the previously known stereotypic genes are not major risk factors for crib-biting in horses, and further genome-wide studies are warranted on larger sample cohorts.

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Indication of a genetic basis of stereotypies in laboratory-bred bank voles (Clethrionomys glareolus)

Cited by 42 publications

References 44 publications

Correlates of birth origin effects on the development of stereotypic behaviour in striped mice, Rhabdomys

Correlates of birth origin effects on the development of stereotypic behaviour in striped mice, Rhabdomys

Correlation analysis between single nucleotide polymorphism of DRD1 gene and stereotyped behavior of blue fox

Exploration of known stereotypic behaviour-related candidate genes in equine crib-biting

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