Indications and effects of exchange transfusion in adults in gynaecology and obstetrics.

Abstract

Haemophilia-Davies et al. period. Of the five patients studied one had a severe degree of haemophilia, in two it was moderate, and in two mild. The mortality rate in the series was 20%, as one patient eventually died of intracranial infection. Carotid angiography was safely performed on seven occasions in four of the patients, human A.H.F. concentrate being used on five occasions and porcine A.H.F. concentrate on two. It is suggested that the administration of these A.H.F. concentrates in sustained and adequate amounts to patients with classical haemophilia who are thought to be suffering from intracranial haemorrhage will possibly make it safe to use the standard techniques in establishing the precise diagnosis, and subsequently to treat a lesion by either conservative or surgical means. We wish to thank our neurosurgical colleagues Mr.

Efficacy and safety of blood transfusion in obstetric patients: systematic review of the literature

“…Table 2 describes study characteristics related to design of study, setting, number of participants, mean age, gender, inclusion and exclusion criteria, and follow-up. Two studies [19,20] were conducted largely in Asia, two others in Africa [16,18], and one in Europe [17]. Randomized trials sample size ranged from 50 [18] to 521 [17], and controlled clinical trials studies from 1,769 [20] to 3,438 [19], and typically included females between the ages of 20 and 40 years.…”

“…Based on title and abstract screening, we assessed 31 full-texts of which we included five publications describing three RCTs [16][17][18] involving 1,090 participants and, two CCTs [19,20] with a total of 5,207 participants. Table 2 describes study characteristics related to design of study, setting, number of participants, mean age, gender, inclusion and exclusion criteria, and follow-up.…”

“…Only Philpott 1966 et al 's study [18] reported on cardiovascular complications; the study reported no events in each of the studied groups. Prick et al 's 2010 [17] study reported a mean physical fatigue score at day three and one week postpartum as reduced by 0.8 and 1.06, respectively, in the transfusion arm compared to women receiving no intervention.…”

“…Figure 2 and Table 3 describe the risk of bias assessment for the RCTs and CCTs. The major issue regarding risk of bias was the extent of allocation concealment and blinding of participants, caregivers, data collectors, statistician, and outcome assessors in all the included studies [16][17][18][19][20]. Only one study [18] had additional problems of missing outcome data, and three other studies [16,19,20] had issues related to generation of allocation.…”

“…Three included studies [17,19,20] allocated women to receive blood transfusion or no intervention and two others [16,18] provided women with either restricted or full blood supplies ( Table 2). Figure 2 and Table 3 describe the risk of bias assessment for the RCTs and CCTs.…”