Indications and Pitfalls of Prepectoral Breast Reconstruction with BraxonⓇ Acellular Dermal Matrix (ADM): A preliminary plastic surgical experience

Bojanic, Christine; Lawrence, Alistair J.; Mitrasinovic, Stefan; Samaras, Stavros; Fopp, Laura J.; Forouhi, Parto; Malata, Charles M.

doi:10.1016/j.bjps.2021.03.124

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…Such use is reported in only one publication in which authors adapted the DTI procedure and implanted an expander into patients whose nipple had to be sacrificed. ( 40 ).…”

Section: Methodsmentioning

confidence: 99%

“…After familiarizing oneself with the ADM and the technique, one will find PPBR to be a simple and standardized procedure that offers oncological patients a less invasive reconstructive strategy, while at the same time increasing the satisfaction levels of surgeons. Deviating from the correct practice and not respecting the surgical indication, especially during the learning curve, leads to a higher risk of postoperative complications ( 40 ). In addition, optimal reconstructive outcomes strictly depend on correct patient selection, as discussed in the next paragraph.…”

Section: Methodsmentioning

confidence: 99%

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Braxon®-assisted prepectoral breast reconstruction: A decade later

et al. 2022

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We are sitting on the cusp of the bioengineered breast era, in which implant-based breast reconstruction is seeing a growing trend and biotechnology research progressively empowers clinical practice. As never before, the choice of biomaterials has acquired great importance for achieving reconstructive outcomes, and the increase in the use of acellular dermal matrices (ADMs) in the field of senology tells us a story of profound upheaval and progress. With the advent of prepectoral breast reconstruction (PPBR), plenty of devices have been proposed to wrap the silicone prosthesis, either completely or partially. However, this has caused a great deal of confusion and dissent with regard to the adoption of feasible reconstructive strategies as well as the original scientific rationale underlying the prepectoral approach. Braxon® is the very first device that made prepectoral implant positioning possible, wrapping around the prosthesis and exerting the proven ADM regenerative potential at the implant–tissue interface, taking advantage of the body's physiological healing mechanisms. To date, the Braxon® method is among the most studied and practiced worldwide, and more than 50 publications confirm the superior performance of the device in the most varied clinical scenarios. However, a comprehensive record of the working of this pioneering device is still missing. Therefore, our aim with this review is to lay a structured knowledge of surgery with BRAXON® and to provide a decision-making tool in the field of PPBR through a complete understanding on the very first device for prepectoral, one decade after its introduction.

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“…Such use is reported in only one publication in which authors adapted the DTI procedure and implanted an expander into patients whose nipple had to be sacrificed. ( 40 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Braxon®-assisted prepectoral breast reconstruction: A decade later

et al. 2022

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“…It does, however, have drawbacks (for example, infection) (93). ADM has so been the subject of investigations to replace the mesh in these operations (Figure 1D) (1,2,21,29,30,33,36,68,(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(94)(95)(96)(97)(98)(99)(100)(101).…”

Section: Chestmentioning

confidence: 99%

“…Several surgical options are being employed for breast reconstruction surgery. The use of ADM in implant-based breast reconstruction following mastectomy has received a lot of attention recently (2,83,91,94,104,(107)(108)(109)(110)(111)(112). The advantages of ADM in implant-based breast surgery include implant stabilization, improved aesthetic outcomes, and reduced capsular contracture risks, donor site morbidity, and postoperative pain (34,83,86,109,(112)(113)(114).…”

Section: Breastmentioning

confidence: 99%

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Acellular dermal matrix in reconstructive surgery: Applications, benefits, and cost

Mohammadyari

Parvin²,

Khorvash³

et al. 2023

Front. Transplant.

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Modern tissue engineering has made substantial advancements that have revolutionized plastic surgery. Acellular dermal matrix (ADM) is an example that has gained considerable attention recently. ADM can be made from humans, bovines, or porcine tissues. ADM acts as a scaffold that incorporates into the recipient tissue. It is gradually infiltrated by fibroblasts and vascularized. Fortunately, many techniques have been used to remove cellular and antigenic components from ADM to minimize immune system rejection. ADM is made of collagen, fibronectin, elastin, laminin, glycosaminoglycans, and hyaluronic acid. It is used in critical wounds (e.g., diabetic wounds) to protect soft tissue and accelerate wound healing. It is also used in implant-based breast reconstruction surgery to improve aesthetic outcomes and reduce capsule contracture risk. ADM has also gained attention in abdominal and chest wall defects. Some studies have shown that ADM is associated with less erosion and infection in abdominal hernias than synthetic meshes. However, its higher cost prevents it from being commonly used in hernia repair. Also, using ADM in tendon repair (e.g., Achilles tendon) has been associated with increased stability and reduced rejection rate. Despite its advantages, ADM might result in complications such as hematoma, seroma, necrosis, and infection. Moreover, ADM is expensive, making it an unsuitable option for many patients. Finally, the literature on ADM is insufficient, and more research on the results of ADM usage in surgeries is needed. This article aims to review the literature regarding the application, Benefits, and costs of ADM in reconstructive surgery.

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