Indications de la recherche des anticorps anti-spermatozoïdes

Effects of Sperm Treatment on the Anti-sperm Antibodies IgG and IgA

“…Among other etiologies, we can evoke the varicocele, the cryptorchidia [9] but rarely testicular tumors [10]. However, many men with no pathological history develop ASA and the occurrence of pregnancy in couples whose man is ASA makes the incrimination of this immunological concept in regard of infertility a relative and variable facts depending on the rate, isotype, site of fixation and action of ASA [11]. The presence of ASA in humans results in disruption of many stages necessary for normal fertilization and can thus have negative effects on fertility, beginning with the agglutination of spermatozoa [12], disturbing their mobility, and may also have acytotoxic effect on spermatozoa through the activation of the classical complement pathway and the formation of the membrane attack complex (CAM) leading to their cytolysis which consequently decrease spermatozoa's' number.…”