Indications for examination of spontaneous abortion specimens: A reassessment

Chromosomal anomaly spectrum in early pregnancy loss in relation to presence or absence of an embryonic pole

“…From an economic perspective, this results in a significant reduction of costs of further parental evaluation, taking into account that the cost of a standard recurrent pregnancy loss protocol is remarkably more expensive than embryonic karyotyping (13). Finally, performing transcervical CVS in missed miscarriages may be a good way to expand the experience of those trainees who seek to learn to perform CVS.…”

Genetic Considerations in Recurrent Pregnancy Loss

“…Routine cytogenetic testing of POCs in couples experiencing RPL has been shown to be cost-effective (Wolf and Horger 1995) and to direct management decisions (Hogge et al 2003), even at a time when analytical methods were based on karyotyping of cultured trophoblast cells and hindered by the occurrence of culture failure and maternal cell contamination. Genetic testing of POCs using nonculturebased techniques such as array comparative genomic hybridization with or without reflex microsatellite single nucleotide polymorphism (SNP) analysis (Rajcan-Separovic et al 2010;Viaggi et al 2013;Mathur et al 2014) (discussed below) is more precise, more detailed, and more reliable than culture-based methods and should add to cost-efficiency and overall utility.…”

Cytogenetic testing of anembryonic pregnancies compared to embryonic missed abortions

“…In our practice, we have found that knowing the karyotype of the miscarried pregnancy frequently helps a patient grieve and pursue further treatment. In addition, some authors have proposed that genetic analysis of POC may be more cost effective than a standard algorithm for the evaluation or recurrent pregnancy loss [12]. For these reasons, physicians may seek to perform cytogenetic evaluation on the products of conception to aid in counseling patients after a pregnancy loss.…”