Keywordsadrenergic β-adrenoceptor antagonists, coronary angiography, drug-related side effects and adverse reactions, metoprolol, tomography, X-ray computed
AIMSTo assess the safety of our clinical practice using off-label intravenous metoprolol to facilitate computed tomographic (CT) coronary angiography.
METHODSA retrospective analysis of scan reports and hospital admissions data was conducted to identify adverse events occurring following CT coronary angiography in patients who had received intravenous metoprolol prior to the scan.
RESULTSA total of 3098 patients were included, of whom 1871 received intravenous metoprolol. Nine hundred and one patients received more than 15 mg and 129 patients received metoprolol despite a resting heart rate <65 beats min −1 . There was a single adverse incident, comprising transient loss of consciousness.
CONCLUSIONSThe use of intravenous metoprolol to facilitate cardiac CT scanning appears safe. Dose limits recommended for other indications, generally in acutely unwell patients, may not need to be as stringent in this population.