Indications of ‘atopic bowel’ in patients with self‐reported food hypersensitivity

Lillestøl, Kristine; Helgeland, Lars; Lied, Gülen Arslan; Florvaag, Erik; Valeur, Jørgen; Lind, Ragna; Berstad, Arnold

doi:10.1111/j.1365-2036.2010.04261.x

Cited by 47 publications

(46 citation statements)

References 47 publications

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“…There have been several reports of increased prevalence of IBS among atopic patients, especially patients with asthma. [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] In a large primary care study of general practitioner diagnosed IBS, the odds ratio for IBS among asthma patients was 2-fold that of controls. 47 Tobin et al 33 reported increased mucosal mast cells in a group of IBS patients with concurrent atopic disease.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Irritable Bowel Syndrome in Singapore and Its Association with Dietary, Lifestyle, and Environmental Factors

Siah

Wong

Chan

et al. 2016

J Neurogastroenterol Motil

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Background/AimsThe prevalence of irritable bowel syndrome (IBS) has risen considerably over the past decade in Singapore. We aim to explore the contribution of changes in diet, lifestyle and habits that may contribute to the increased prevalence and development of IBS. MethodsThis is a survey-based cross-sectional population study aimed to gather demographic, socio-economical, lifestyle, dietary, antibiotic usage and other related information. Subjects were adult male or female Singaporeans aged 21 years or above. Association of the factors gathered with the presence or absence of IBS (by Rome III criteria) was assessed using chi-square or Fisher's exact test. Variables with a level of statistical significance of 0.1 or less in the univariate analysis were entered into a stepwise logistic regression model. ResultsA total of 297 subjects participated in the study (female 60.3%). Overall, 20.9% subjects fulfilled the Rome III IBS criteria. Univariate analysis showed that IBS was associated with pet ownership, antibiotic usage, late dinner, (> 9 PM) and consumption of Western meals, coffee, and bread. The multivariate logistic regression analyses showed that IBS was independently associated with being a pet owner (P = 0.008; OR, 2.5; 95% CI, 1.278-5.037). ConclusionsThe prevalence of IBS was 20.9% using the Rome III criteria in our study. The association between IBS and pet ownership will need further investigation. (J Neurogastroenterol Motil 2016;22:670-676)

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Section: Discussionmentioning

confidence: 99%

“…Atopic patients were also shown to have increased intestinal permeability and density of IgE-bearing mast cells. 36 Sensitisation to food allergens, which were reported by patients to induce their gastrointestinal symptoms, was not shown (both via measurement of serum-specific food IgE and skin prick test).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Irritable Bowel Syndrome in Singapore and Its Association with Dietary, Lifestyle, and Environmental Factors

Siah

Wong

Chan

et al. 2016

J Neurogastroenterol Motil

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“…As is known, dysregulated immune activation on the epithelial barrier surfaces is common in both allergy and IBS [17]. Lillestol et al [16] reported earlier that elevated numbers of IgEpositive cells in duodenal mucosa were found in patients with atopy compared to nonatopic patients. Besides, numbers of IgE-positive cells in duodenal mucosa were significantly correlated with levels of serum total IgE.…”

Section: Discussionmentioning

confidence: 99%

“…Lower GI symptoms such as diarrhea are common in children with allergy [14,15]. Intestinal permeability was significantly increased in patients with atopy compared to nonatopic patients [16]. Seasonal inhalation of birch pollen has been suggested to cause a duodenal increase in IgE-bearing cells [5].…”

Section: Discussionmentioning

confidence: 99%

Association between Allergic Diseases and Irritable Bowel Syndrome: A Retrospective Study

Fang

Zhang

Lü

et al. 2018

Int Arch Allergy Immunol

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Background: The relationship between allergic disease and irritable bowel syndrome (IBS) is poorly understood. We aimed to investigate the potential association as well as the underlying immunological mechanisms. Methods: A retrospective case-control study of 108 atopic patients from among outpatients in an allergy clinic (allergic rhinitis [AR], n = 49; chronic urticaria [CU], n = 59) and 74 controls from among ward companions was conducted from November 2016 to March 2017. The detection rates and related gastrointestinal (GI) symptoms of IBS, as well as immunological indices, were calculated. Results: CU patients had a trend of increase in the detection of IBS compared to controls (OR = 4.846; 95% CI 0.967–24.279, p = 0.077). Loose stools (OR = 2.406; 95% CI 1.075–5.386, p < 0.05) and viscous stools (OR = 2.665; 95% CI 1.250–5.682, p < 0.05) were more common in CU patients. Atopic patients positive for serum total immunoglobulin E (IgE) (OR = 3.379; 95% CI 1.088–10.498, p < 0.05) or house dust mite (HDM)-specific IgE (OR = 3.640; 95% CI 1.228–10.790, p < 0.05) were more likely to have abdominal bloating. Besides, a positive association between levels of total IgE and severity of abdominal bloating was observed (p < 0.05). An HDM-specific IgE-positive reaction was independently associated with abdominal bloating in atopic patients (p < 0.05). Conclusions: Allergic disease has a clear clinical association with IBS with more frequent and severe symptoms of IBS. CU patients have a tendency to suffer from IBS, usually with diarrhea. Serum total IgE and HDM-specific IgE are positively correlated with GI symptoms in atopic patients.

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“…It has been reported that food hypersensitivity is more prevalent in patients with IBS and those with atopic diseases. 5 Patients with celiac disease or IBS experience clinically indistinguishable GI symptoms. 6 Despite these shortcomings, the significant association reported in this large-scale study lends further support to a common pathophysiological basis of these conditions.…”

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confidence: 99%

Editorial: the overlap of atopy and functional gastrointestinal disorders in primary care

2014

Aliment Pharmacol Ther

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Indications of ‘atopic bowel’ in patients with self‐reported food hypersensitivity

Abstract: Patients with self-reported food hypersensitivity had a high prevalence of IBS and atopic disease. Atopic patients had increased intestinal permeability and density of IgE-bearing cells compared with non-atopic patients, but gastrointestinal symptoms did not differ between groups.

Cited by 47 publications

References 47 publications

Prevalence of Irritable Bowel Syndrome in Singapore and Its Association with Dietary, Lifestyle, and Environmental Factors

Prevalence of Irritable Bowel Syndrome in Singapore and Its Association with Dietary, Lifestyle, and Environmental Factors

Association between Allergic Diseases and Irritable Bowel Syndrome: A Retrospective Study

Editorial: the overlap of atopy and functional gastrointestinal disorders in primary care

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