Indicators for Malignant Transformation in Patients With Lymphoepithelial Lesion

MALT lymphoma of the sublingual gland: A case report with current overview of diagnostic and therapeutic strategies

“…MALT lymphoma is commonly associated with preexisting autoimmune diseases, such as Sjögren's syndrome, or with chronic immune stimulation of the salivary gland, which accounts for 52% of MALT lymphomas in the maxillofacial region. 6 , 7 Several genetic abnormalities that result in the amplification of NF‐κB and NOTCH signaling have been recently reported as possible causes. 8 , 9 For instance, frequently occurring translocations, such as t(11;18)(q21;q21), t(14;18)(q32;q21), and t(1;14)(p22;q32), which deregulate MALT1, BCL10, and BIRC3 have been reported to activate NF‐κB signaling.…”

“…Although salivary tissues do not contain lymphocytes under normal circumstances, they can acquire lymphocytes during inflammation. MALT lymphoma is commonly associated with preexisting autoimmune diseases, such as Sjögren's syndrome, or with chronic immune stimulation of the salivary gland, which accounts for 52% of MALT lymphomas in the maxillofacial region 6,7 . Several genetic abnormalities that result in the amplification of NF‐κB and NOTCH signaling have been recently reported as possible causes 8,9 .…”

Lymphoepithelial carcinoma of the parotid gland: Clinicopathological analysis of 146 cases from a single institute

“…Most salivary gland LECs develop de novo (primary LEC). However, it has been reported that salivary gland LECs also develop from lymphoepithelial lesions 16 . This indicates malignant transformation of the epithelial elements of a lymphoepithelial lesion (secondary LEC).…”