Indicators of fetal growth and bipolar disorder: a Danish national register-based study

Abstract

None of the indicators of fetal growth under study could be identified as risk factors for bipolar disorder, suggesting that the etiologies of schizophrenia and bipolar disorder, at least in part, are different.

Perinatal factors and the risk of bipolar disorder in Finland

“…The lack of association between birth weight and BPD has been seen in three previous studies (Øgendahl et al, 2006; Bain et al, 2000; Eaton et al, 2000). Similarly, three previous population-based studies (Nosarti et al, 2012; Eaton et al, 2000; Øgendahl et al, 2006) have examined the association between gestational age and BPD and found no association. However, these negative findings are in contrast to a study showing increased risk of BPD in children born preterm (Nosarti et al, 2012).…”

“…Findings of the studies on gestational age and on birth weight adjusted for gestational age have been inconsistent. A Swedish study (Nosarti et al, 2012) found preterm birth to be associated with increased risk of BPD, while two Danish studies (Øgendahl et al, 2006; Eaton et al, 2000) failed to show similar associations. A Danish study (Laursen et al, 2007) showed increased risk in preterm children born small for gestational age (SGA) whereas SGA was not associated with BPD in two Swedish studies (Nosarti et al, 2012; Hultman et al, 1999) and a Scottish study (Bain et al, 2000).…”

“…Six population-based epidemiological studies have examined the association between perinatal risk factors and BPD in the offspring (Nosarti et al, 2012; Øgendahl et al, 2006; Eaton et al, 2000; Laursen et al, 2007; Hultman et al, 1999; Bain et al, 2000). Three of these studies included cases with affective psychosis including BPD (Eaton et al, 2000, Hultman et al, 1999; Bain et al, 2000).…”

“…Three of these studies included cases with affective psychosis including BPD (Eaton et al, 2000, Hultman et al, 1999; Bain et al, 2000). Among the indicators of fetal growth, birth weight was examined in only three studies (Øgendahl et al, 2006; Eaton et al, 2000; Bain et al, 2000), and was shown not to be associated with BPD in two Danish studies (Øgendahl et al, 2006; Eaton et al, 2000) and one Scottish study (Bain et al, 2000). Findings of the studies on gestational age and on birth weight adjusted for gestational age have been inconsistent.…”

“…First, the sample size in the studies varied widely from 69 (Eaton et al, 2000) to 4490 (Laursen et al, 2007). Second, there was wide variation in the categorization of the perinatal risk factors (Nosarti et al, 2012; Laursen et al, 2007; Øgendahl et al, 2006; Eaton et al, 2000; Bain et al, 2000; Hultman et al, 1999) thereby resulting in lack of uniformity in interpreting the findings. Lastly, there were extensive differences in adjustment for confounding factors with only three studies (Laursen et al, 2007; Øgendahl et al, 2006; Nosarti et al, 2012) adjusting for the effects of parental age and psychiatric history and only two studies adjusting for some measure of maternal socioeconomic status (Øgendahl et al, 2006; Nosarti et al, 2012).…”