Indicators of lipid peroxidation and antioxidant status in the serum and saliva of patients with active Crohn's disease

Szczeklik, Katarzyna; Krzyściak, Wirginia; Cibor, Dorota; Domagała-Rodacka, Renata; Pytko-Polończyk, Jolanta; Mach, Tomasz; Owczarek, Danuta

doi:10.20452/pamw.4273

Cited by 28 publications

(48 citation statements)

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“…This hypothesis appears to be in-line with the concept of accelerated cardiovascular risk and mortality rate with an increase in the inflammatory burden [ 16 , 17 ]. This has been proven in our previous study with respect to the increased levels of lipid peroxidation, suggesting the need to reduce both inflammation and lipid peroxidation [ 4 ] in patients with CD.…”

Section: Introductionmentioning

confidence: 62%

“…In our previous studies, lipid peroxidation, as measured by the level of MDA, was found to be increased, and PON-1 activity was found to be decreased in the patients with CD than that of control volunteers [ 4 ]. These results are partially in line with the results obtained by Boehm et al, and Boehm et al, who obtained elevated levels of MDA in patients with CD.…”

Section: Discussionmentioning

confidence: 99%

“…These changes, commenced by the infiltration of inflammatory cells in the intestinal mucosa, are associated with the release of inflammatory mediators, such as reactive oxygen species (ROS) or reactive nitrogen species (RNS). Both ROS and RNS are proinflammatory factors, which drive each other in CD and inhibit defensive systems (antioxidative enzymes, such as PON-1), resulting in the cellular damage and intensified lipid peroxidation [ 4 ]. Malondialdehyde (MDA) is one of well-known end products of lipid peroxidation induced by ROS.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease

et al. 2018

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Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD. The CD activity index was based on the current classification. Plasma PON-1 was measured in 47 patients with CD, and in 23 control volunteers. Using quantitative variables such as receiver operating characteristics (ROC) (area under the curve (AUC)), the diagnostic utility of PON-1 in differentiating the severity of CD was assessed. Circulating PON-1 was found to be decreased in the CD group compared to the control group (269.89 vs. 402.56 U/L, respectively), and it correlated well with the disease activity. PON-1 correlated positively with hemoglobin (Hb) (r = 0.539, p < 0.001), hematocrit (Ht) (r = 0.48, p < 0.001), total cholesterol (TC) (r = 0.343, p < 0.001), high density lipoprotein (HDL) (r = 0.536, p < 0.001), low density lipoprotein (LDL) (r = 0.54, p < 0.001), and triglyceride (TG) (r = 0.561, p < 0.001) and correlated negatively with white blood cell count (WBC) (r = −0.262, p = 0.029), platelet count (PLT) (r = −0.326, p = 0.006), C-reactive protein (CRP) (r = −0.61, p < 0.001), and malondialdehyde (MDA) (r = −0.924, p < 0.001). PON-1 as a marker for CD differentiation possessed a sensitivity and specificity of 93.62% and 91.30%, respectively. CD was found to be associated with the decrease in the levels of PON-1, which correlates well with activity of the disease and reflects the intensification of inflammation, as well as intensified lipid peroxidation. High sensitivity and specificity of PON-1 determines its selection as a good screening test for CD severity.

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Section: Introductionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease

et al. 2018

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“…In the study from the year 2018, Szczeklik et al [ 26 ] investigated the diagnostic usefulness of selected oxidative stress markers in the saliva and serum in CD patients (with an active and inactive form of the disease). Among the exclusion criteria, apart from smoking, diabetes, periodontal disease and using antioxidants in the past 6 months, were pregnancy or lactation, alcohol abuse, severe systemic disease, acute illness, oral mucosal disease, orthodontic appliances, current biologic therapy, abdominal abscess, intestinal stricture and active gastrointestinal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Salivary Biomarkers for Diagnosis of Inflammatory Bowel Diseases: A Systematic Review

Nijakowski

Surdacka

2020

IJMS

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Saliva as a biological fluid has a remarkable potential in the non-invasive diagnostics of several systemic disorders. Inflammatory bowel diseases are chronic inflammatory disorders of the gastrointestinal tract. This systematic review was designed to answer the question “Are salivary biomarkers reliable for the diagnosis of inflammatory bowel diseases?”. Following the inclusion and exclusion criteria, eleven studies were included (according to PRISMA statement guidelines). Due to their heterogeneity, the potential salivary markers for IBD were divided into four groups: oxidative status markers, inflammatory cytokines, microRNAs and other biomarkers. Active CD patients manifest decreased activity of antioxidants (e.g., glutathione, catalase) and increased lipid peroxidation. Therefore, malondialdehyde seems to be a good diagnostic marker of CD. Moreover, elevated concentrations of proinflammatory cytokines (such as interleukin 1β, interleukin 6 or tumour necrosis factor α) are associated with the activity of IBD. Additionaly, selected miRNAs are altered in saliva (overexpressed miR-101 in CD; overexpressed miR-21, miR-31, miR-142-3p and underexpressed miR-142-5p in UC). Among other salivary biomarkers, exosomal PSMA7, α-amylase and calprotectin are detected. In conclusion, saliva contains several biomarkers which can be used credibly for the early diagnosis and regular monitoring of IBD. However, further investigations are necessary to validate these findings, as well as to identify new reliable salivary biomarkers.

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“…Chronic inflammation and injury of the intestine can lead to serious complications such as intestinal fibrosis and intestinal obstruction. Therefore, the research on the pathogenesis of CD intestinal fibrosis has become a popular direction [58]. Under normal physiological conditions, fibroblasts aggregate in damaged tissues to promote the repair of damaged tissues.…”

Section: Discussionmentioning

confidence: 99%

Effect of Loureirin B on Crohn’s disease rat model induced by TNBS via IL-6/STAT3/NF-κB signaling pathway

Sun

Wen

et al. 2020

Chin Med

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Background: Crohn's disease (CD) is a chronic relapsing form of inflammatory bowel disease, seriously threatening human beings health. However, the pathogenesis of CD is still unclear and there is no specific effective drug for treatment of CD. Resina Donis (RD) obtained from Dracaena cochinchinensis (Lour.) S. C. Chen (Liliaceae), has been used for the treatment of CD clinically. Loureirin B (LB) is one of the most important chemical compositions and physiologically active ingredients of resina draconis. It has the molecular structure propan-1-one, 1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)-1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl) propan-1-one. The aim of this study was to investigate the effect of LB on CD and explore the underlying mechanisms. Methods and results: In this study, the result demonstrated that LB prolonged the survival time of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced rats and alleviated colonic damage in a dose dependent manner. Besides, LB remarkably ameliorated TNBS-induced inflammatory response via regulation of cytokines in the colonic tissues. Moreover, LB could reverse the established fibrosis and impede the accumulation infiltration, and improve the apoptosis induced by TNBS in a dose dependent manner. Further, LB dramatically suppressed TNBS-induced the activation of IL-6/STAT3/NF-κB signaling pathway. Conclusions: These findings suggested that LB could be beneficial regarding ameliorating TNBS-induced CD, which may represent a novel approach to treat CD and provide an alternative choice for disorders associated with CD.

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Indicators of lipid peroxidation and antioxidant status in the serum and saliva of patients with active Crohn's disease

Cited by 28 publications

References 0 publications

Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease

Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease

Salivary Biomarkers for Diagnosis of Inflammatory Bowel Diseases: A Systematic Review

Effect of Loureirin B on Crohn’s disease rat model induced by TNBS via IL-6/STAT3/NF-κB signaling pathway

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