Indicators of Obesity and Serum Levels of Triglycerides in the First Trimester of Pregnancy as the Predictors of Gestational Diabetes Mellitus among Urmia Women

Pazhohan, Azar; Moradali, Monireh Rezaee; Pazhohan, Nahideh; Sadeghyanifar, Ali

doi:10.5812/modernc.67186

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Although GDM screening is recommended for pregnant women between the 24 th and 28 th weeks, determining the thickness of the subcutaneous adipose tissue during the first trimester may deliver a faster predictor for the early detection of GDM. This would offer a more optimal screening method for GDM, providing the possibility of effectively managing the condition and preventing its complications (5). Considering the high prevalence of GDM, it seems necessary to use this method to reliably predict the incidence of the disease as soon as possible (6).…”

Section: Introductionmentioning

confidence: 99%

The Role of Abdominal Ultrasound in the Prediction of GDM in Early Pregnancy

Dalili,

Moeinaddini,

Gozashti

et al. 2023

Journal of Kerman University of Medical Sciences

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Background: To detect gestational diabetes mellitus (GDM) in pregnant women as soon as possible, this study aimed to investigate the role of ultrasound in predicting GDM in early pregnancy by measuring the thickness of abdominal subcutaneous adipose tissue. Methods: This paper is a longitudinal study performed on pregnant women at 11-14 weeks of pregnancy. All the women referred during this period were screened for the thickness of abdominal subcutaneous adipose tissue, which was measured using trans-abdominal ultrasound. The patients were followed up by performing the oral glucose tolerance test (OGTT) between the weeks of 24 and 28. Finally, abdominal subcutaneous adipose tissue thickness and other variables were compared between women with and without GDM. Oral consent was obtained from patients. Results: Overall, 210 pregnant women at 11-14 weeks of gestation were enrolled in the study. The mean of abdominal subcutaneous adipose tissue thickness was measured using linear probe ultrasound as 1.72±0.33 mm. The incidence of GDM was significantly associated with maternal age and weight, parity, family history of diabetes, and histories of preeclampsia, hypertension, and recurrent abortion. There was also a statistically significant relationship between GDM and ultrasound-derived subcutaneous adipose tissue thickness at weeks 11-14 of pregnancy (P<0.0001). At the cut-off point of 2.01, the sensitivity, specificity, and area under the curve (AUC) values were 91%, 92%, and 0.96, respectively. Conclusion: Measuring the thickness of the abdominal subcutaneous adipose tissue during early pregnancy may be useful in predicting GDM in the second trimester of pregnancy. Maternal higher age and weight gain, increased parity, and positive family histories of diabetes, preeclampsia, hypertension, and recurrent abortion may also increase the risk of GDM.

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Section: Introductionmentioning

confidence: 99%

The Role of Abdominal Ultrasound in the Prediction of GDM in Early Pregnancy

Dalili,

Moeinaddini,

Gozashti

et al. 2023

Journal of Kerman University of Medical Sciences

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Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis

et al. 2021

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Gestational diabetes mellitus (GDM) can have adverse effects on pregnancy. GDM is associated with changes in the lipid profile of pregnant women. Finding out the early ways to diagnose GDM can prevent the adverse outcomes. This meta-analysis study aimed to determine the effect of GDM on lipid profile. PubMed, ProQuest, Web of Science, Scopus, Science Direct, Google Scholar, and ClinicalTrial were systematically searched for published articles relating to GDM until 2021 according to PRISMA guidelines. Newcastle Ottawa scale was used to assess the quality of the studies. Thirty-three studies with a sample size of 23,792 met the criteria for entering the meta-analysis. Pooled standardized mean difference (SMD) for total cholesterol (TC) and triglyceride (TG) was 0.23 mg/dL (95% CI: 0.11–0.34) and 1.14 mg/dL (95% CI: 0.91–1.38), respectively. The mean of TC and TG in people with GDM was higher than that in normal pregnant women. A similar pattern was observed for the very low-density lipoprotein (VLDL) and TG/high-density lipoprotein (HDL) ratio, with pooled SMD of 0.99 mg (95% CI: 0.71–1.27) and 0.65 mg (95% CI: 0.36–0.94), respectively. Pooled SMD for HDL was −0.35 mg/dL (95% CI: −0.54 to −0.16), women with GDM had a mean HDL lower than normal pregnant women. Although pooled SMD was higher for low-density lipoprotein (LDL) in the GDM group, this difference was not significant (0.14 [95% CI: −0.04 to 0.32]). Of all the lipid profiles, the largest difference between the GDM and control groups was observed in TG (SMD: 1.14). Elevated serum TG had the strongest effect on GDM. Higher levels of TC, LDL, VLDL, and TG/HDL ratio, and lower level of HDL were exhibited in GDM group. So, these markers can be considered as a reliable marker in the diagnosis of GDM.

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Lysophosphatidylcholine Impairs the Mitochondria Homeostasis Leading to Trophoblast Dysfunction in Gestational Diabetes Mellitus

Hung,

Chan,

Chan

et al. 2024

Antioxidants

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Gestational diabetes mellitus (GDM) is a common pregnancy disorder associated with an increased risk of pre-eclampsia and macrosomia. Recent research has shown that the buildup of excess lipids within the placental trophoblast impairs mitochondrial function. However, the exact lipids that impact the placental trophoblast and the underlying mechanism remain unclear. GDM cases and healthy controls were recruited at Kaohsiung Medical University Hospital. The placenta and cord blood were taken during birth. Confocal and electron microscopy were utilized to examine the morphology of the placenta and mitochondria. We determined the lipid composition using liquid chromatography-mass spectrometry in data-independent analysis mode (LC/MSE). In vitro studies were carried out on choriocarcinoma cells (JEG3) to investigate the mechanism of trophoblast mitochondrial dysfunction. Results showed that the GDM placenta was distinguished by increased syncytial knots, chorangiosis, lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) overexpression, and mitochondrial dysfunction. Lysophosphatidylcholine (LPC) 16:0 was significantly elevated in the cord blood LDL of GDM patients. In vitro, we demonstrated that LPC dose-dependently disrupts mitochondrial function by increasing reactive oxygen species (ROS) levels and HIF-1α signaling. In conclusion, highly elevated LPC in cord blood plays a pivotal role in GDM, contributing to trophoblast impairment and pregnancy complications.

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Indicators of Obesity and Serum Levels of Triglycerides in the First Trimester of Pregnancy as the Predictors of Gestational Diabetes Mellitus among Urmia Women

Cited by 3 publications

References 28 publications

The Role of Abdominal Ultrasound in the Prediction of GDM in Early Pregnancy

The Role of Abdominal Ultrasound in the Prediction of GDM in Early Pregnancy

Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis

Lysophosphatidylcholine Impairs the Mitochondria Homeostasis Leading to Trophoblast Dysfunction in Gestational Diabetes Mellitus

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