Índice de massa corporal apresenta boa correlação com o perfil pró-aterosclerótico em crianças e adolescentes

Abstract

Background: More recently, the association of different risk factors has been described as the metabolic syndrome. Different definitions are being used for the same syndrome. Regardless of the name or classification, it has been well established that a cardiovascular cluster including overweight/obesity, increased blood pressure, and lipid and glucose abnormalities are associated with an increased risk of atherosclerosis in adults.Objective: The aim of this study was to correlate body mass index percentiles with blood pressure, insulin resistance index, and lipid profiles in children and adolescents, which characterize a proatherosclerotic profile.Methods: Cardiovascular risk factor clusters were evaluated in 118 children and adolescents divided according to body mass index percentile (BMIP) quartiles: Q1 (n=23) with BMIP <50%, Q2 (n=30) with BMIP between 50 and 85%, Q3 (n=31) with BMIP between 85 and 93%, and Q4 (n=34) with the BMIP > 93%. Statistically significant differences were not observed for age (F=2.1; p=0.10); sex (chi-square test=3.0; p=0.38), and ethnicity (chi-square test=4.7; p=0.20) between different quartiles.Results: A statistically significant difference was observed for systolic BP (F=15.4; p<0.0001), diastolic BP (F=9.5; p<0.0001), glycemia (F=9.6; p<0.0001), insulin (F=12.9; p<0.0001), HOMAir (F=30.8; p<0.0001), and triglyceride levels (F=2.7; p=0.05) between the different quartiles.Conclusion: Excess weight evaluated by BMIP was associated with increased blood pressure, triglycerides, HOMAir index, and low HDL-cholesterol, a proatherosclerotic profile in children and adolescents.Key Words: Body mass índex; child; adolescent; risk factors.Mailing Address: Heno Ferreira Lopes • Av. Dr. Enéas de C. Aguiar, 44, Bloco II, 2ª andar, sala 8 -05403-000 -Cerqueira César -São Paulo, SP, Brazil E-mail: hipheno@incor.usp.br Manuscript received on 08/20/08; revised manuscript received on 10/02/08; accepted on 10/21/08. Body Mass Index Has a Good Correlation with Proatherosclerotic Profile in Children and Adolescents IntroductionAccording to the World Health Organization 1 , obesity is assuming epidemic proportions all over the world and is considered a chronic pediatric disease, more dangerous than malnutrition, as it is associated with a large number of comorbidities. The problems associated with obesity include psychosocial problems (low self-esteem, affecting academic ability and relationships), social problems (prejudice), and culminate in the association of central obesity, insulin resistance, hypertension, and dyslipidemia, which characterize a cluster of cardiovascular risk factors also called metabolic syndrome (MS). Metabolic syndrome is associated with an increased chance of atherosclerotic disease, steatohepatitis, gallstones found in sedentary subjects with overnutrition and genetic predisposition 2 . The prevalence of this situation is increasing in children and adolescents, and type 2 diabetes is appearing in this population more frequently 3 . There are other clinical situations associat...

Birth weight was negatively correlated with plasma ghrelin, insulin resistance, and coenzyme Q10 levels in overweight children

“…A positive association between BMI and HOMA-IR in children and adolescents has been shown in several studies [42,43], while there was no correlation between current BMI and insulin resistance in the present study. The main reason for no correlation between two parameters might be due to the narrow BMI range, because the subjects in this study were limited to overweight.…”

Association between carotid intima-media thickness and index of central fat distribution in middle-aged and elderly Chinese

“…Adipokines such as leptin and plasminogen activator inhibitor type 1 are mostly produced by visceral adipose tissue. These adipokines play important regulatory roles in a variety of biological processes, including insulin resistance and atherosclerosis [31-36]. Indulekha K et al [37] reported that visceral fat accumulated with increasing glucose intolerance and was associated with decreased levels of adiponectin and increased levels of high sensitive C-reactive protein, tumor necrosis factor-alpha, oxidized LDL, HOMA-IR and CIMT.…”

Perfil lipídico y consumo de frutas y verduras en un grupo de jóvenes de 10 a 19 años, según el índice de masa corporal

“…El estudio de Costa et al mostró cómo el porcentaje de IMC en niños y adolescentes, distribuido por cuartiles, se asoció con diferentes factores de riesgo cardiovascular, entre ellos, la concentración de TG, cuyo promedio se incrementó a medida que aquel lo hacía, como también el c-HDL, cuya concentración disminuyó con el aumento en el porcentaje del IMC 24 . En nuestro estudio se observaron resultados similares en las niñas, quienes incrementaron los valores de TG a medida que se alteró el IMC, y el valor de c-HDL disminuyó al comparar las niñas obesas con las que presentaron un IMC adecuado.…”