SOARES, J.S. Concentration evaluation of metals, trace and major elements in sediment profiles of Tietê River, State of São Paulo. 2020. 209p. Dissertation (Master in Nuclear Technology) -Instituto de Pesquisas Energéticas e Nucleares -IPEN -CNEN/SP. The Tietê River (RT) is the most important river in the state of SP due, mainly, to its hydroelectric potential. With an extension of 1,100 km, is considered one of the most polluted rivers in the world, notably in the stretch of the Metropolitan Region of SP. The present study evaluated the concentration and distribution of toxic metals, major and trace elements in sedimentary profile samples, collected in: Salesópolis (T1), Santana do Parnaíba (T2), Pirapora Bom Jesus (T3), between Salto de Itu and Porto Feliz (T4), Tietê (T5) and between Laras and Anhembi (T6). Multielemental analyzes were performed using Instrumental Neutron Activation Analysis (INAA) and Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES). The enrichment factor (FE) and the geoaccumulation index (IGeo) were calculated to assess the presence of sources of pollution, using the NASC reference values and also background sediment values for the Alto Tietê region. The concentrations of Cd, Cr, Cu, Ni, Pb, Zn and As were compared to the TEL and PEL oriented values, to assess sediment quality.From the results, it was possible to conclude that: profile T1, Salesólopolis, seems to be free of pollution by anthropogenic contribution; T2, Santana do Parnaíba, concentration values much lower than those found in studies carried out in the region; T3, Rasgão reservoir, presented the highest concentrations for toxic metals, As and other elements, confirming the results of the literature. This is due to the strong urban influence of the São Paulo capital, with the discharge of domestic and industrial effluents in the RT; T4, Médio Tietê, there was an improvement in the quality of the sediments, with a classification between good and regular, for toxic metals and bad for Zn; T5, Tietê, sediment quality rating between good and regular for all metals; T6, Anhembi, sediments classified as of poor quality for Cr, Ni and Zn. In general, there was serious to moderate pollution for toxic metals and other elements, along the Tietê River basin, with greater concern for Zn and Cr, derived from domestic, agricultural and industrial effluents.