Indices of metal proteins (transferrin ceruloplasmin) in overweight and obese children

Сорокман, Т В; Sokolnyk, S.V.; POPELYUK, Alexandra-Maria V.; Sokolʹnyk, S. O.; Макарова, О.В.; Безрук, В. В.

doi:10.31688/abmu.2019.54.2.12

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…In turn, this pro-inflammatory status has also been associated with intracellular copper efflux, mainly in the form of ceruloplasmin [ 28 ]. Hence, this is finally mirrored in increased blood content of total copper [ 7 , 8 , 9 ], and especially of cuproproteins [ 29 , 30 ], in agreement with our size-fractionation findings. This hypothesis linking inflammation with alterations in the copper-zinc ratio was corroborated by correlation analysis ( Figure 1 A,B), as reflected by the positive association found between plasma copper, in both total and HMM fractions, and multiple inflammatory markers (e.g., white blood cell-based inflammatory indices).…”

Section: Discussionsupporting

confidence: 90%

Altered Metal Homeostasis Associates with Inflammation, Oxidative Stress, Impaired Glucose Metabolism, and Dyslipidemia in the Crosstalk between Childhood Obesity and Insulin Resistance

et al. 2022

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Metals are redox-active substances that participate in central biological processes and may be involved in a multitude of pathogenic events. However, considering the inconsistencies reported in the literature, further research is crucial to disentangle the role of metal homeostasis in childhood obesity and comorbidities using well-characterized cohorts and state-of-the-art analytical methods. To this end, we studied an observational population comprising children with obesity and insulin resistance, children with obesity without insulin resistance, and healthy control children. A multi-elemental approach based on the size-fractionation of metal species was applied to quantify the total content of various essential and toxic elements in plasma and erythrocyte samples, and to simultaneously investigate the metal fractions conforming the metalloproteome and the labile metal pool. The most important disturbances in childhood obesity were found to be related to elevated circulating copper levels, decreased content of plasmatic proteins containing chromium, cobalt, iron, manganese, molybdenum, selenium, and zinc, as well as the sequestration of copper, iron, and selenium within erythrocytes. Interestingly, these metal disturbances were normally exacerbated among children with concomitant insulin resistance, and in turn were associated to other characteristic pathogenic events, such as inflammation, oxidative stress, abnormal glucose metabolism, and dyslipidemia. Therefore, this study represents one-step further towards a better understanding of the involvement of metals in the crosstalk between childhood obesity and insulin resistance.

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Section: Discussionsupporting

confidence: 90%

Altered Metal Homeostasis Associates with Inflammation, Oxidative Stress, Impaired Glucose Metabolism, and Dyslipidemia in the Crosstalk between Childhood Obesity and Insulin Resistance

et al. 2022

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“…As mentioned above, HFD-induced obese mice present lower hephaestatin mRNA levels [ 114 ]. However, adipose tissue from obese humans (both adults and children) seems to contribute to higher circulating CP levels [ 121 , 122 , 123 ]. Additionally, livers of HFD-induced obese mice presented lower iron levels and increased endoplasmic reticulum stress (ERS), together with an impaired expression of NCOA4 and ferritin [ 124 ].…”

Section: Iron Metabolism In Obesitymentioning

confidence: 99%

Iron Metabolism in Obesity and Metabolic Syndrome

González-Domínguez

Visiedo-Garcia

Domínguez-Riscart

et al. 2020

IJMS

128

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Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related to the development of several comorbidities such as nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronic inflammation and anemia, among others. Within this tangled interplay between these comorbidities and associated pathological conditions, obesity has been closely linked to important perturbations in iron metabolism. Iron is the second most abundant metal on Earth, but its bioavailability is hampered by its ability to form highly insoluble oxides, with iron deficiency being the most common nutritional disorder. Although every living organism requires iron, it may also cause toxic oxygen damage by generating oxygen free radicals through the Fenton reaction. Thus, iron homeostasis and metabolism must be tightly regulated in humans at every level (i.e., absorption, storage, transport, recycling). Dysregulation of any step involved in iron metabolism may lead to iron deficiencies and, eventually, to the anemic state related to obesity. In this review article, we summarize the existent evidence on the role of the most recently described components of iron metabolism and their alterations in obesity.

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“…Studies that have looked at the effects on insulin resistance following vitamin D administration in obese people are contradictor y. Vitamin D deficiency is associated with hyperglycemia, hyperinsulinemia and insulin resistance [41,42]. Von Hurst et al, following vitamin D treatment in women with insulin resistance and overweight, showed a decrease in HOMA-IR, but with no effect on glucose level, lipid profile and inflammatory markers [40].…”

Section: Vitamin D Supplementationmentioning

confidence: 99%

The Complex Context of the Involvement of Vitamin D Deficiency in Obesity

Stănescu¹,

Grăjdeanu²,

Totan³

et al. 2019

Rev. Chim.

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The prevalence of obesity is increasing and morbidity and mortality increase with it. Vitamin D plays an important role in obesity. Determining the exact relationship between obesity and vitamin D may represent a new perspective in the approach and treatment of obesity. Clarifying whether supplementation with vitamin D in overweight people can prevent obesity and whether supplementation in obese people can help weight loss are essential.

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Indices of metal proteins (transferrin ceruloplasmin) in overweight and obese children

Cited by 3 publications

References 26 publications

Altered Metal Homeostasis Associates with Inflammation, Oxidative Stress, Impaired Glucose Metabolism, and Dyslipidemia in the Crosstalk between Childhood Obesity and Insulin Resistance

Altered Metal Homeostasis Associates with Inflammation, Oxidative Stress, Impaired Glucose Metabolism, and Dyslipidemia in the Crosstalk between Childhood Obesity and Insulin Resistance

Iron Metabolism in Obesity and Metabolic Syndrome

The Complex Context of the Involvement of Vitamin D Deficiency in Obesity

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