Indices of salt and water metabolism in tubenose goby Proterorhinus marmoratus pallas, introduced into Rybinsk Reservoir, and in indigenous carp Cyprinus carpio L. Depending on environmental salinity

Martemyanov, V. I.; Borisovskaya, E. V.

doi:10.1134/s2075111712020075

Cited by 16 publications

(10 citation statements)

References 16 publications

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“…The critical salinity studied in the present paper is within the habitable salinity range of water for the freshwater teleosts. The living of goldfi sh in saline estuarine sections of rivers and the absence of mortality in experiments on fi sh acclimation to CS evidence the effectiveness of the homeostatic mechanisms of fi sh in CS conditions (21,25,26). This was also confi rmed by the results of the present study.…”

Section: Comparison Of Water-salt Homeostasis Parameters In the Body ...supporting

confidence: 86%

Goldfish as a model for studying the effect of hypernatremia on blood plasma lipoproteins

Андреева¹,

Martemyanov²,

Ilya³

et al. 2022

BLL

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AIM: To evaluate the effect of hypernatremia on the organization of blood plasma high density lipoproteins (HDL) in goldfi sh; to compare the state of hypernatremia in fi sh and humans; to assess the possible risks and consequences of the effect of hypernatremia on human plasma lipoproteins. METHODS: The fi sh were acclimated for 20 days at a critical salinity of 11.5 g/L; after that the salt water was gradually "desalinated". The concentration of Na + and the content of total water were determined in tissues, cells, and body fl uids. The HDL organization was assessed by the number of apolipoprotein molecules per particle. The methods of fl ame spectrophotometry, electrophoresis and MALDI were used. RESULTS: In fresh water, the state of normonatremia was maintained in the fi sh body; at critical water salinity, the state of hypernatremia. Against the background of hypernatremia, the initial signs of muscle and erythrocyte dehydration appeared in fi sh, the total water content in the plasma did not change, and HDL disintegrated into small particles, which, upon restoration of normonatremia, were combined into the original large forms. CONCLUSION: In goldfi sh at the state of normonatremia, large forms of HDL are stable while at the state of hypernatremia, the small forms of HDL are stable. Under conditions of a hypertonic environment and plasma hypernatremia, the breakdown of HDL prevents the loss of water from the fi sh organism and reduces the threat of their dehydration. Human hypernatremia is characterized by plasma sodium levels comparable to that in goldfi sh, however accompanied by life-threatening metabolic changes. The results of this study may be useful for assessing the risks of HDL breakdown at hypernatremia and for the development of protocols for the treatment of pathological conditions in humans (Fig. 4, Ref. 45).

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Section: Comparison Of Water-salt Homeostasis Parameters In the Body ...supporting

confidence: 86%

Goldfish as a model for studying the effect of hypernatremia on blood plasma lipoproteins

Андреева¹,

Martemyanov²,

Ilya³

et al. 2022

BLL

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“…Within the tolerant salinity range, the total body water content of carp and tubenose goby is supported at stable level, demonstrating standard physiological functioning of the osmotic regulation. Hypohydremia is observed when the organism is exposed to water of critical salinity, indicating problems with osmotic regulation (14). Decrease of water level in the muscles of two toad species acclimated to hyperosmotic salinity has been observed (34).…”

Section: Discussionmentioning

confidence: 99%

“…It is determined that in freshwater hydrobionts in the zone of critical salinity (10)(11)(12)(13)(14)(15), and in euryhaline species during transition from freshwater to seawater (16)(17)(18)(19)(20) the level of sodium and chloride ions in the blood plasma increases. This situation is an ideal model for studying adaptation mechanisms of various organs and tissues of organisms to increasing sodium concentration of extracellular fl uid in vivo.…”

Section: Introductionmentioning

confidence: 99%

Volume regulation of muscle cells in the carp Cyprinus carpio in response to hypernatremia

Martemyanov¹,

Poddubnaya²

2019

BLL

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BACKGROUND: Hypernatremia supports the movement of water from the intracellular to the intercellular space. This shift leads to cells shrinkage and disruption of intracellular processes, representing risk factors of morbidity and mortality in clinical circumstances. On the other hand, hypernatremia triggers protective mechanisms that counteract damage of cells. OBJECTIVES: To determine in experiments in vivo the ranges of sodium content regulation in the blood plasma of carp characterizing the norm and hypernatremia. To identify the patterns volume regulation of skeletal muscles cells in response to hypernatremia. METHODS: Carps were acclimating for 3 weeks to a different salinity in the range of 0-12 g/L. In the plasma and muscle tissue the concentration of sodium, potassium, calcium and magnesium was determined by the method of fl ame spectrophotometry. Water content in the muscles has been additionally determined. RESULTS: Carps acclimated in the salinity range of 0-6 g/L, maintained the concentration of sodium in blood plasma within of the range of 129-135 mmol/L (normonatremia). In the salinity zone of 6-12 g/L concentration of sodium in the blood plasma of fi sh has increased to 207 mmol/L (hypernatremia). Hypernatremia was causing the increase of the sodium, potassium, calcium and magnesium content in carp muscles and the drop of water level. CONCLUSIONS: Muscle tissue of carp adapts to hypernatremia by means of increasing inorganic ions by 70.8 % and organic osmolytes by 29.2 % (Fig. 2, Ref. 51).

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“…Determination in plasma of total water (tw) and its fractions -free (fwf) and bound (bwf) -was carried out using the method of drying samples, given that the content of bwf reflects the changes in the concentration of organic osmolytes that bind water (Martemyanov, 2014(Martemyanov, , 2020Martemyanov, Borisovskaya, 2012). First, weighed strips of Whatman 3MM chromatographic paper 5x10 mm in size were saturated by plasma.…”

Section: Determination Of Total Water and Its Fractions In Plasmamentioning

confidence: 99%

“…A further increase in water salinity (>10 g kg -1 ) leads to a significant increase in the concentration of Na + in plasma and, as a result, an increase in the levels of stress markers -cortisol and glucose (Mommsen et al, 1999;Nakkrasae et al, 2015). Under such conditions, fish growth and food consumption deteriorate, and signs of dehydration appear (Lahlou et al, 1969;De Boeck et al, 2000;Martemyanov, Borisovskaya, 2012).…”

Section: Introductionmentioning

confidence: 99%

Blood plasma high-density lipoprotein remodeling as a reserve mechanism for goldfish adaptation to critical salinity conditions

Андреева

Lamash

Martemyanov

et al. 2022

Preprint

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In goldfish Carassius auratus acclimated under critical salinity conditions (CS, 11.5 g kg -1 ), the concentrations of cortisol, glucose, Na + in the blood plasma increased significantly, also large β - HDL particles decomposed into small α- ones with a higher negative charge and a smaller number of apolipoproteins molecules in 1 particle composition. Particles remodeling led to ~1.5-2-fold increase in their number per unit plasma volume. Taking into account that under CS conditions the contribution of organic osmolytes to plasma osmolality increased by ~2%, and the content of the bound water fraction in plasma increased by ~4 times, we assumed that goldfish have a “reserve” mechanism for maintaining homeostasis: when the possibilities of increasing the concentration of Na + and organic metabolites in plasma are limited, remodeling of HDL particles and an increase in their amount in plasma can help to maintain its hyperosmotic status and additional influx of water into the body.

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Indices of salt and water metabolism in tubenose goby Proterorhinus marmoratus pallas, introduced into Rybinsk Reservoir, and in indigenous carp Cyprinus carpio L. Depending on environmental salinity

Cited by 16 publications

References 16 publications

Goldfish as a model for studying the effect of hypernatremia on blood plasma lipoproteins

Goldfish as a model for studying the effect of hypernatremia on blood plasma lipoproteins

Volume regulation of muscle cells in the carp Cyprinus carpio in response to hypernatremia

Blood plasma high-density lipoprotein remodeling as a reserve mechanism for goldfish adaptation to critical salinity conditions

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