Indirect alloresponses are more pronounced in non-rejecting lung than heart allografts

Webber, Steven A.; Bentlejeweski, C; Boyle, G.J.; Law, Yuk M.; Bowman, Pamela; Miller, Susan A.; Gribar, Steven C.; Fitzsimmons, Alec; McCurry, Kenneth R.; Murali, Srinivas; Griffith, Bartley P.; Zeevi, Adriana

doi:10.1016/s1053-2498(00)00303-x

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“…They observed the precursor frequency of allopeptide‐reactive T cells to be 3–24‐fold higher in recipients with BOS compared to recipients without BOS. Zeevi and colleagues (27) studied blood and biopsy samples from heart and lung/heart‐lung recipients and observed more indirect alloreactivity was demonstrated in lung/heart‐lung than in heart recipients during graft quiescence. They speculated that the strong tendency toward early and more frequent chronic rejection in the lung recipients may be a result of the predominance of indirect alloreactivity in these recipients.…”

Section: Cellular Assays Testing the Indirect Pathway Of Alloantigen mentioning

confidence: 99%

Cellular methods used to evaluate the immune response in transplantation

Reinsmoen

2002

Tissue Antigens

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Cellular assays have been developed to test for various effector, cytotoxic, and regulatory functions of T cells and have been used throughout the history of clinical transplantation to assess the immune profile of solid organ and marrow recipients. One goal of these cellular studies has been to determine if posttransplant changes in the donor antigen-specific cellular response could predict good and poor graft outcome, thereby allowing for individualization of immunosuppression. This review outlines the use of established and newly developed cellular assays to assess the dynamic processes of the posttransplant immune response and to provide insights into the mechanisms involved and potential points for intervention.

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Section: Cellular Assays Testing the Indirect Pathway Of Alloantigen mentioning

confidence: 99%

Cellular methods used to evaluate the immune response in transplantation

Reinsmoen

2002

Tissue Antigens

View full text Add to dashboard Cite

show abstract

Indirect alloresponses are more pronounced in non-rejecting lung than heart allografts

Cited by 1 publication

References 0 publications

Cellular methods used to evaluate the immune response in transplantation

Cellular methods used to evaluate the immune response in transplantation

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