Indirect determination of nitrogenated drugs by atomic absorption spectrometry

Abstract

The accuracies obtained and the rapidity of the technique permit the analysis of solid samples on a routine basis.

Indirect Atomic Absorption Determination of Cocaine via Formation and Liquid‐liquid Extraction of the Iron(III)‐cocaine Complex

“…In addition to 1,2-dichloroethane, the following organic solvents, chloroform, cyclohexane, iso-octane, and toluene, were examined with respect to their ability to extract the [cocaiNH] + [FeCl 4 ]species. As reported earlier 24,25,31 of these, only the 1,2-dichloroethane gave acceptable results.…”

“…Analytical procedures based on ion-pair formation between the protonated alkaloid and negatively charged metal complexes extractable into organic solvents have been reported. [23][24][25][26][27][28][29][30][31] Such procedures for cocaine have utilized metal-containing species Co(SCN) 4 2-, Ni(SCN) 4 (3) (n = 0,1,2,3...)…”

“…4,5 Although chromatographic methods dominate the list of procedures reported, [6][7][8][9][10][11][12][13][14][15][16][17][18] other methods of determination include voltametry, 19 amperometry, 20 potentiometry, 21 and calorimetry. 22 Analytical procedures based on the principles of ion-pair formation between the protonated alkaloid and a negatively charged metal-containing species have been developed for the indirect AAS determination of alkaloids [23][24][25][26] and chemiluminescence determination of atropine. 27 Although ion-pair formation of protonated cocaine was initially utilized in a qualitative test, 28 its quantitative aspects were recently employed for the AAS determination of cocaine.…”

Kinetics and thermodynamic parameters of the thermal decomposition of bis(imipraminium)tetrachlorocuprate, bis(imipraminium)tetrachloromercurate and imipraminium reineckate

“…The complexes of SCN À with Cr 3+ , Zn 2+ , Co 2+ and Fe 3+ were used to determine positively charged organic analyte [1][2][3]. Organic bases such as primary, secondary and tertiary amines were determined in pharmaceuticals by a colorimetric method based on the formation of colored ion-pairs with cobalt thiocyanate [4].…”

Colorimetric and Atomic Absorption Spectrometric Determination of Mucolytic Drug Ambroxol Through Ion-Pair Formation with Iron and Thiocyanate

“…In presented study, preliminary experiments for reaction conditions were carried out by varying the nature of organic solvents. It is well known that the ketones especially methyl isobutyl ketone, and alcohols extract the inorganic complexes formed between thiocyanate and various cations and are not valid as extraction solvents whereas solvents with low polarity, which do not contain oxygen, such as chloroform and 1,2-dichloroethane selectively extract the ion pair complex [46]. Since 1,2-dichloroethane is not an ecologically friendly solvent; chloroform was preferred as the suitable medium for extraction.…”