The present study includes analytical methods for determination of the drugs Chlorpromazine hydrochloride (CPZ) and trifluoperazine hydrochloride (TFPH) in some pharmaceuticals using molecular absorption, indirect AAS, in addition to investigating complexes obtained throughout. Chlorpromazine hydrochloride and trifluoperazine hydrochloride are widely used for the treatment of schizophrenia. Synthetic formulas for the prepared drug complexes were proposed through the results of the molar ratios of the combination between the drug and each of copper, lead, chrome and iron.