Indirect evidence of sympathetic stimulation by regadenoson

Stress cardiomyopathy associated with vasodilator stress testing

“…It is important to note that activation of adenosine receptors, with adenosine or other agents such as regadenoson and dipyridamole, induces a sympathetic surge in the heart that is most manifested by an increase in the heart rate following the administration of these agents. [22][23][24] This is yet another mechanism for a possible trigger of stress cardiomyopathy in this patient and simultaneously provides supportive evidence of sympathetic stimulation as a root cause of the syndrome as discussed above. Indeed, there are other reported cases of stress cardiomyopathy associated with vasodilator stress tests in the absence of bronchospasm.…”