2017
DOI: 10.1016/j.vaccine.2017.04.032
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Indirect (herd) protection, following pneumococcal conjugated vaccines introduction: A systematic review of the literature

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Cited by 114 publications
(100 citation statements)
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References 63 publications
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“…Our analyses underscore the previously observed large variation in IPD incidence between countries before introduction of PCVs [22,37,74]. In young children, the highest incidence was observed in the United States and was two to five times higher than in most other countries analyzed.…”
Section: Discussionsupporting
confidence: 84%
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“…Our analyses underscore the previously observed large variation in IPD incidence between countries before introduction of PCVs [22,37,74]. In young children, the highest incidence was observed in the United States and was two to five times higher than in most other countries analyzed.…”
Section: Discussionsupporting
confidence: 84%
“…The observed increase in the burden of NVT IPD is suggestive of serotype replacement [22], and warrants careful monitoring. Similar to our findings in adults ≥65 years old, a systematic review on the indirect effect of PCVs showed variable reductions in overall IPD in older adults across countries [37]. The observed decreases in VT IPD in older adults indicate that higher valent PCVs are effective in inducing herd protection in the unvaccinated population, the duration of which is yet not clear.…”
Section: Discussionsupporting
confidence: 84%
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“…Olağan bir pnömokok rezervuarı olan küçük çocuklardaki asemptomatik taşıyıcılığın sonlandırılması, yalnız aşılan-mış kişilerdeki değil; aynı zamanda aşılanmayanlardaki, özellikle kardeşler ve oyun arkadaşlarındaki ve yine ebeveynler ve diğer aşılanmamış erişkinlerdeki hastalık hızını da azaltmaktadır. KPA'nın bu koruyucu etkisi dolaylı etki ya da "sürü" etkisi ("herd effect") olarak adlandırılmaktadır (1,5,6,10,11,19,105,106).…”
Section: Aşılamanın Maliyet Etkinliğiunclassified
“…It is clear that the immunity induced by PCVs also partially protects recipients against nasopharyngeal carriage of VT pneumococci [3]. This is important because the nasopharyngeal pneumococcal population is the source of transmission to other hosts, so the reduced carriage has led to herd immunity that has reduced VT disease in other age groups in many populations in which infants and/or toddlers have received PCVs [4,5].…”
Section: Introductionmentioning
confidence: 99%