Indirect impact of SARS‐CoV‐2 pandemic on pregnancy and childbirth outcomes: A nine‐month long experience from a university center in Lombardy

Ornaghi, Sara; Fumagalli, Simona; Montalvo, C; Beretta, Greta; Invernizzi, Francesca; Nespoli, Antonella; Vergani, Patrizia

doi:10.1002/ijgo.13990

Cited by 13 publications

(4 citation statements)

References 79 publications

(240 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, very little evidence has been published regarding the impact of COVID-19 on the incidence of GDM stratified by gestational age of infection. In a retrospective analysis of prospectively collected data on uninfected and asymptomatic women, the authors concluded that pandemic-related control measures may have affected exercise levels in pregnant women, especially in those in their first and early second trimesters, thus ultimately favoring GDM [ 42 ]. This finding was further supported by a retrospective cross-sectional study, indicating that SARS-CoV-2 infection at the time of hospitalization for delivery did not significantly impact GDM because the parameter is a function of gestational age and changes over a longer period [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

The impact of gestational weeks of Coronavirus disease 2019 (COVID-19) infection on perinatal outcomes

Yi,

Chen,

Meng

et al. 2024

Reprod Health

View full text Add to dashboard Cite

Background To evaluate the relationship between coronavirus disease 2019 (COVID-19) infection at different time points during pregnancy and perinatal outcomes. Methods This retrospective study included 611 women who hospitalized for delivery between December 7 and April 30, 2023. Based on the different pregnancy weeks infected with COVID-19, the participants were divided into four groups: Group 1 (14–27+6 weeks gestation), Group 2 (28–36+6 weeks gestation), Group 3 (37–39+6 weeks gestation), and Group 4 (≥ 40 weeks gestation). Data including maternal demographic characteristics, clinical profiles, and perinatal outcomes were analyzed. Results There were no significant differences in maternal demographic characteristics among the four groups (P > 0.05). Compared to Groups 3 and 4, a higher rate of fever was noted in Groups 1 and 2 (P < 0.05). The frequency of preeclampsia and gestational diabetes mellitus showed a decreasing trend as pregnancy progressing (P < 0.05). Preterm delivery and neonatal intensive care unit admission were more frequently observed in Groups 1 and 2 than in Groups 3 and 4 (P < 0.05). Multivariate logistic regression analysis demonstrated that the timing of gestation in which COVID-19 was infected was not associated with preterm delivery and neonatal intensive care unit admission (P > 0.05), whereas gestational age at COVID-19 infection was negatively associated with the occurrence of preeclampsia and gestational diabetes mellitus (P < 0.05). Conclusions Gestational age at COVID-19 infection is a simple parameter that predicts adverse perinatal outcomes to aid clinicians in determining to provide early enhanced prenatal care and increased monitoring to reduce maternal complications.

show abstract

Section: Discussionmentioning

confidence: 99%

The impact of gestational weeks of Coronavirus disease 2019 (COVID-19) infection on perinatal outcomes

Yi,

Chen,

Meng

et al. 2024

Reprod Health

View full text Add to dashboard Cite

show abstract

“…A Chinese study showed that pregnant women who experienced lockdown had an increase in HbA1C in those with gestational diabetes and an increase in pregnancy-induced hypertension in normoglycemic women (17). Italian studies also have shown an increase in gestational diabetes during the pandemic (18,19). An Israeli study showed an increase in both hypertension and gestational diabetes during the pandemic (20).…”

Section: Maternal Morbiditiesmentioning

confidence: 99%

Higher NICU admissions in infants born at ≥35 weeks gestational age during the COVID-19 pandemic

et al. 2023

View full text Add to dashboard Cite

BackgroundIncreasing evidence has shown that the COVID-19 pandemic has had a profound negative impact on vulnerable populations and a significant effect on maternal and neonatal health. We observed an increase in the percentage of infants admitted to NICU from 8% to 10% in the first year of the pandemic. This study aimed to compare the delivery room outcomes, NICU admissions and interventions, and neonatal outcomes two years before and during the pandemic.MethodsThis was a retrospective study in a public hospital between pre-COVID-19 (April 2018–December 2019) and COVID-19 (April 2020–December 2021). Data were obtained from all live births at ≥35 weeks gestation (GA). Maternal and neonatal demographics, delivery room (DR), and NICU neonatal outcomes were compared between the study periods using simple bivariable generalized estimating equations (GEE) regression. Multivariable GEE logistic regression analysis was performed to adjust for the effects of baseline differences in demographics on the outcomes.ResultsA total of 9,632 infants were born ≥35 weeks gestation during the study period (pre-COVID-19 n = 4,967, COVID-19 n = 4,665). During the COVID-19 period, there was a small but significant decrease in birth weight (33 g); increases in maternal diabetes (3.3%), hypertension (4.1%), and Hispanic ethnicity (4.7%). There was a decrease in infants who received three minutes (78.1% vs. 70.3%, p < 0.001) of delayed cord clamping and increases in the exclusive breastfeeding rate (65.9% vs. 70.1%, p < 0.001), metabolic acidosis (0.7% vs. 1.2%, p = 0.02), NICU admission (5.1% vs. 6.4%, p = 0.009), antibiotic (0.7% vs. 1.7%, p < 0.001), and nasal CPAP (1.2% vs. 1.8%, p = 0.02) use. NICU admissions and nasal CPAP were not significantly increased after adjusting for GA, maternal diabetes, and hypertension; however, other differences remained significant. Maternal hypertension was an independent risk factor for all these outcomes.ConclusionDuring the COVID-19 pandemic period, we observed a significant increase in maternal morbidities, exclusive breastfeeding, and NICU admissions in infants born at ≥35 weeks gestation. The increase in NICU admission during the COVID-19 pandemic was explained by maternal hypertension, but other adverse neonatal outcomes were only partly explained by maternal hypertension. Socio-economic factors and other social determinants of health need to be further explored to understand the full impact on neonatal outcomes.

show abstract

“…Since the beginning of the COVID-19 pandemic, the prevalence of GDM has increased compared to previous years [43][44][45]. Different theories regarding the pathophysiology of SARS-CoV-2 infection in relation to the occurrence of GDM have been proposed, including an increase in cases of newly diagnosed GDM or failure to comply with the first-line treatment for GDM due to worsening hyperglycemia (see next section).…”

Section: Current Evidence On the Association Between Covid-19 And Dia...mentioning

confidence: 99%

COVID-19 and Gestational Diabetes: The Role of Nutrition and Pharmacological Intervention in Preventing Adverse Outcomes

et al. 2022

View full text Add to dashboard Cite

Pregnant women with GDM affected by COVID-19 seem to be at higher risk of adverse maternal and neonatal outcomes, especially those with overweight or obesity. Good glycemic control seems to be the most effective measure in reducing the risk of GDM and severe COVID-19. For such purposes, the Mediterranean diet, micronutrient supplementation, and physical activity are considered the first line of treatment. Failure to achieve glycemic control leads to the use of insulin, and this clinical scenario has been shown to be associated with an increased risk of adverse maternal and neonatal outcomes. In this review, we explore the current evidence pertaining to the pathogenesis of SARS-CoV-2 leading to the main complications caused by COVID-19 in patients with GDM. We also discuss the incidence of complications caused by COVID-19 in pregnant women with GDM according to their treatment.

show abstract

Indirect impact of SARS‐CoV‐2 pandemic on pregnancy and childbirth outcomes: A nine‐month long experience from a university center in Lombardy

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 13 publications

References 79 publications

The impact of gestational weeks of Coronavirus disease 2019 (COVID-19) infection on perinatal outcomes

The impact of gestational weeks of Coronavirus disease 2019 (COVID-19) infection on perinatal outcomes

Higher NICU admissions in infants born at ≥35 weeks gestational age during the COVID-19 pandemic

COVID-19 and Gestational Diabetes: The Role of Nutrition and Pharmacological Intervention in Preventing Adverse Outcomes

Contact Info

Product

Resources

About