Indirect lymph node lymphangiography using an iodine-based contrast medium and projection radiography following submucosal injection in a rabbit model

Dietrich, Arne; Wuttke, Matthias; Walter, F.; Leon, Isabella; Kloeppel, R.; Schoenfelder, Manfred

doi:10.1007/s00423-002-0326-6

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Tanaka et al (35) reported the incidental lymph node uptake of ethiodized oil after submucosal injection during CT examinations to evaluate the extent of esophageal cancer spread. Also, some previous reports (36, 37) demonstrated the regional lymph node uptake of ethiodized oil based contrast media with mural injection into the stomach of gastric cancer patients (36) and with submucosal injection into the rectum of healthy rabbits (37). However, these studies used simple radiography instead of CT examination.…”

Section: Discussionmentioning

confidence: 93%

Sentinel Node Mapping of VX2 Carcinoma in Rabbit Thigh with CT Lymphography Using Ethiodized Oil

et al. 2014

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ObjectiveTo assess the feasibility of computed tomography (CT) lymphography using ethiodized oil for sentinel node mapping in experimentally induced VX2 carcinoma in the rabbit thigh.Materials and MethodsThis experiment received approval from the institutional animal use and care administrative advisory committee. Twenty-three rabbits with VX2 carcinoma in the thigh underwent CT before and after (1 hour, 2 hour) peritumoral injection of 2 mL ethiodized oil. After the CT examination, sentinel nodes were identified by peritumoral injection of methylene blue and subsequently removed. The retrieved sentinel and non-sentinel lymph nodes were investigated with radiographic and pathologic examinations. Based on the comparison of CT findings with those of radiographic and pathologic examinations, the diagnostic performance of CT for sentinel node identification was assessed.ResultsAll 23 rabbits showed 53 ethiodized oil retention nodes on post-injection CT and specimen radiography, and 52 methylene blue-stained nodes at the right femoroiliac area. Of the 52 blue-stained sentinel nodes, 50 nodes demonstrated ethiodized oil retention. Thus, the sentinel node detection rate of CT was 96% (50 of 52). On pathologic examination, 28 sentinel nodes in 17 rabbits (nodes/rabbit, mean ± standard deviation, 1.7 ± 0.6) harbored metastasis. Twenty seven of the 28 metastatic sentinel nodes were found to have ethiodized oil retention.ConclusionComputed tomography lymphography using ethiodized oil may be feasible for sentinel node mapping in experimentally induced VX2 carcinoma in the rabbit thigh.

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Section: Discussionmentioning

confidence: 93%

Sentinel Node Mapping of VX2 Carcinoma in Rabbit Thigh with CT Lymphography Using Ethiodized Oil

et al. 2014

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Early Gastric Cancer: Feasibility of CT Lymphography with Ethiodized Oil for Sentinel Node Mapping

Kim¹,

Lee²,

Park³

et al. 2013

Radiology

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Indirect lymph node lymphangiography using an iodine-based contrast medium and projection radiography following submucosal injection in a rabbit model

Abstract: This method appears useful when investigating local lymph nodes following submucosal injection due to its passage into lymphatic vessels and storage in lymph nodes.

Cited by 2 publications

References 22 publications

Sentinel Node Mapping of VX2 Carcinoma in Rabbit Thigh with CT Lymphography Using Ethiodized Oil

Sentinel Node Mapping of VX2 Carcinoma in Rabbit Thigh with CT Lymphography Using Ethiodized Oil

Early Gastric Cancer: Feasibility of CT Lymphography with Ethiodized Oil for Sentinel Node Mapping

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