Indirect mechanism of histamine-induced nociception in temporomandibular joint of rats

Ting, Elizabeth; Roveroni, Renata C.; Ferrari, Luiz F.; Lotufo, Celina Monteiro da Cruz; Veiga, Maria-Cecilia F.A.; Parada, Carlos Amílcar; Tambeli, Cláudia Herrera

doi:10.1016/j.lfs.2007.07.012

Cited by 20 publications

(7 citation statements)

References 56 publications

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“…Inflammatory mediators, such as histamine, serotonin, bradykinin and prostaglandins, are regulators of the microcirculation and are also known to be pain‐producing substances . Animal models suggest that some of these molecules may mediate pain in temporomandibular joints . However, it should be noted that: (i) in these animal models, exogenous inflammatory reagents (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…1 Animal models suggest that some of these molecules may mediate pain in temporomandibular joints. [2][3][4][5] However, it should be noted that: (i) in these animal models, exogenous inflammatory reagents (e.g. carrageenan, zymosan, formalin or complete Freund adjuvant) are injected into temporomandibular joints; and (ii) evidence is lacking for the mediators described above being released or produced within the masticatory muscles themselves.…”

Section: Introductionmentioning

confidence: 99%

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Roles played by histamine in strenuous or prolonged masseter muscle activity in mice

Yoneda

Yaoita

Tsuchiya

et al. 2013

Clin Exp Pharma Physio

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Bruxism and/or clenching, resulting in fatigue or dysfunction of masseter muscles (MM), may cause temporomandibular disorders. Functional support of the microcirculation is critical for prolonged muscle activity. Histamine is a regulator of the microcirculation and is supplied by release from its stores and/or by de novo production via the induction of histidine decarboxylase (HDC). Interleukin (IL)-1, a cytokine involved in temporomandibular disorders, is an inducer of HDC. In the present study, we examined the roles of histamine, HDC and IL-1 in MM activity. Experiments were conducted using our R+G+ model. A mouse restrained (R+) inside a narrow cylinder (front end blocked with a thin plastic strip) gnaws away (G+) the strip to escape, with the weight reduction in the strip serving as an index of MM activity. Fexofenadine (a peripherally acting histamine H1 receptor antagonist) reduced MM activity in normal mice. Both H1 receptor-deficient and HDC-deficient mice exhibited low MM activity. Prolonged R+G+ induced HDC activity in MM. Mast cell-deficient mice exhibited strikingly low HDC induction in MM (and also in the quadriceps femoris muscle) in response to muscle activity or IL-1β. Mast cells were present around blood vessels and nerves in the epimysium and perimysium of MM. These results, together with others reported previously, suggest that: (i) peripheral histamine supports strenuous MM activity; (ii) strenuous MM activity stimulates mast cells to release histamine and to induce HDC (which replenishes the histamine pool in mast cells, possibly mediated by IL-1); and (iii) peripheral histamine H1 receptor antagonists may be effective in treating temporomandibular disorders or preventing prolonged clenching and/or bruxism.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Roles played by histamine in strenuous or prolonged masseter muscle activity in mice

Yoneda

Yaoita

Tsuchiya

et al. 2013

Clin Exp Pharma Physio

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“…Histamine might induce nociception via an indirect mechanism by stimulating release of 5‐hydroxytryptamine (5‐HT) and activation of 5‐HT3 receptors on sensory afferent . Besides, in vitro studies showed that histamine could induce production of matrix metalloproteinases (MMPs), tumour necrosis factor‐α (TNF‐α) and prostaglandin E (PGE), degrading enzymes and inflammatory mediators well‐known implicated in degenerative joint disease , in synovial fibroblasts and human articular chondrocytes .…”

Section: Discussionmentioning

confidence: 99%

Histamine and substance P in synovial fluid of patients with temporomandibular disorders

Long

Jiang

et al. 2014

J of Oral Rehabilitation

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Although psychosocial factors and malocclusion are regarded as potential causes of temporomandibular disorders (TMD), the underlying pathogenesis is poorly understood. Recent studies suggest that substance P (SP), which has been associated with both psychosocial factors and malocclusion, and histamine, whose release can be induced by SP, may be implicated in the pathogenetic process. This study was designed to measure the concentration of histamine and SP in synovial fluid (SF) of both 38 patients with TMD and 11 healthy controls, and analyse the correlation between histamine and SP. Patients with TMD were divided into three subgroups: displaced disc with reduction (DDR), displaced disc without reduction (DDNR) and osteoarthritis (OA), with 10, 13, 15 subjects in every subgroup, respectively. After collecting SF samples, histamine and SP levels were measured by enzyme-linked immunosorbent assay analysis (ELISA) and calibrated by bicinchoninic acid (BCA)-quantified protein level in the samples. The results suggest that OA group presented a significantly higher level of both histamine and SP than DDNR, DDR and healthy control groups. Histamine or SP in DDR and DDNR groups tend to be higher than control group, but no significance was found. Painful TMJs show higher histamine and SP than painless TMJs. Correlation analysis reveals a significant correlation between histamine and SP concentrations. Collectively, this study showed the changes of histamine and SP in the SF from different stages of TMD and found a significant correlation between the two substances, suggesting their potential implication in the pathogenesis of TMD.

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“…Therefore, it is possible that the behavioral changes observed are due to other effects of cromoglycate. Neverthless the stabilization of cromoglycate and the antagonisms of incision pain were ascertained in postoperative pain7–9 along with other kinds of pain models 21–23. We could have examined the effects of histamine and serotonin antagonists, however, not only histamine and serotonin but other kinds of mediators are released after activation of mast cells by surgical incision.…”

Section: Discussionmentioning

confidence: 99%

Mast cell stabilization promotes antinociceptive effects in a mouse model of postoperative pain

Yasuda¹,

Kido²,

Ohtani³

et al. 2013

JPR

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BackgroundNerve injury and consequent inflammatory responses produced by surgical incision result in a complicated pain status which still affects half of all surgical patients. Therefore, it is essential for anesthesiologists to identify the mechanisms of postoperative pain. Mast cells are resident cells of connective tissue and the mucosa that participate in the immune response. Degranulation of mast cells is involved in the development of postoperative pain and can be induced by surgical incision. The aim of this study was to investigate whether stabilization of mast cells causes an antinociceptive effect in a mouse model of postoperative pain.MethodsPostoperative pain was induced by making an incision in the hind paw of BALB/c mice. The mast cell membrane stabilizer cromoglycate (200 μg/20 μL) was injected before incision of the paw, and postoperative pain responses were measured by assessing guarding behavior, withdrawal threshold to mechanical stimuli, and latency of heat pain behavior 1, 2, and 7 days after the incision.ResultsThe incision produced guarding pain, mechanical allodynia, and heat hypersensitivity. Cromoglycate decreased the guarding pain score (day 1) and the withdrawal threshold to mechanical stimuli (days 1, 2, and 7). However, the withdrawal latency to heat was not affected by cromoglycate treatment.ConclusionCromoglycate significantly attenuated the pain response expressed as guarding pain and mechanical allodynia in a mouse model of postoperative pain. Thus, mast cell activation is likely a mechanism of postoperative pain and is an interesting target for the development of new therapies.

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Indirect mechanism of histamine-induced nociception in temporomandibular joint of rats

Cited by 20 publications

References 56 publications

Roles played by histamine in strenuous or prolonged masseter muscle activity in mice

Roles played by histamine in strenuous or prolonged masseter muscle activity in mice

Histamine and substance P in synovial fluid of patients with temporomandibular disorders

Mast cell stabilization promotes antinociceptive effects in a mouse model of postoperative pain

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