Indirect Myocardial Revascularization

Emini, Ramiz; Wildhirt, Stephen M.; Guilliard, Peter; Brünner, Horst; Beyer, M; Liebold, Andreas

doi:10.1161/circulationaha.112.126037

Cited by 11 publications

(13 citation statements)

References 4 publications

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“…Progress of cellular therapies to treat heart disease continues to increase in clinical trials, dependent upon the cellular therapy applied [11]. With the overall population of heart disease continuing to grow and the average age of a person diagnosed with heart disease decreasing [5], responding successfully to this growing market becomes increasingly urgent.…”

Section: Strategic Managementmentioning

confidence: 99%

“…Consequently, CVD is the leading cause of morbidity and mortality worldwide with approximately 400,000 new cases per year (a total diagnosis affecting over 28 million people) [5,6]. The total US healthcare cost for diagnosis and treatment of CVD exceeds $32 billion per year with a 50% mortality rate within 5 years of diagnosis [5,7]. Of individuals suffering with CVD, approximately 5 million people suffer heart failure (HF) [5].…”

Section: Introductionmentioning

confidence: 99%

“…The total US healthcare cost for diagnosis and treatment of CVD exceeds $32 billion per year with a 50% mortality rate within 5 years of diagnosis [5,7]. Of individuals suffering with CVD, approximately 5 million people suffer heart failure (HF) [5]. Deaths from HF exceeds that of either breast or colon cancer [7].…”

Section: Introductionmentioning

confidence: 99%

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Empowering Adult Stem Cells for Myocardial Regeneration V2.0

Broughton

Sussman

2016

Circulation Research

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Much has changed since our survey of the landscape for myocardial regeneration powered by adult stem cells four years ago (Mohsin et al., Empowering adult stem cells for myocardial regeneration. Circ Res. 2011; 109(12):1415–1428) [1]. The intervening years since that first review has witnessed an explosive expansion of studies that advance both understanding and implementation of adult stem cells in promoting myocardial repair. Painstaking research from innumerable laboratories throughout the world is prying open doors that may lead to restoration of myocardial structure and function in the wake of pathologic injury. This global effort has produced deeper mechanistic comprehension coupled with an evolving appreciation for the complexity of myocardial regeneration in the adult context. Undaunted by both known and (as yet) unknown challenges, pursuit of myocardial regenerative medicine mediated by adult stem cell therapy has gathered momentum fueled by tantalizing clues and visionary goals. This concise review takes a somewhat different perspective than our initial treatise, taking stock of the business sector that has become an integral part of the field while concurrently updating “state of affairs” in cutting edge research. Looking retrospectively at advancement over the years as all reviews eventually must, the fundamental lesson to be learned is best explained by Jonatan Mårtensson: “Success will never be a big step in the future. Success is a small step taken just now.”

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Section: Strategic Managementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Empowering Adult Stem Cells for Myocardial Regeneration V2.0

Broughton

Sussman

2016

Circulation Research

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“…African Americans continue to face the greatest burden of hypertension in the world (Go et al, 2013). Disparities in cardiovascular disease (CVD) prevalence, morbidity, and mortality account for a substantial portion of observed differences in life expectancy between African Americans and Whites (Kochanek, Arias, & Anderson, 2013; Miniño, 2013), and hypertension alone accounts for 15% of all CVD deaths among African Americans (Wong, Shapiro, Boscardin, & Ettner, 2002).…”

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confidence: 99%

Examining the association between perceived discrimination and heart rate variability in African Americans.

Hill

Hoggard

Richmond

et al. 2017

Cultural Diversity & Ethnic Minority Psychology

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Objective Previous research attempting to delineate the role of discrimination in racial/ethnic disparities in hypertension has focused largely on blood pressure, which is chiefly governed by the sympathetic branch of the autonomic nervous system. Consequently, few studies have considered the role of the parasympathetic branch and particularly its regulation of the heart via the vagus nerve. Method In the present cross-sectional study, we employed hierarchical linear regressions to examine associations between perceived ethnic discrimination and resting heart rate variability (HRV), an important biomarker of parasympathetic cardiac modulation and overall health, in a sample (N = 103) of young, healthy African American participants (58% female, Mage = 19.94 years, SD = 2.84). Results After accounting for demographic factors and health status characteristics, lifetime discrimination emerged as an inverse predictor of HRV. When subdomains of discrimination were considered, discrimination attributable to threats or actual acts of aggression was also predictive of lower HRV. Conclusions Our findings suggest that a greater lifetime burden of discrimination and discriminatory harassment and/or assault is associated with lower resting HRV in African Americans. The implications of these findings are discussed in the context of past, present and emerging research emphasizing biological linkages between discrimination and health.

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“…Even with persistent efforts to lower blood pressure and reduce smoking, the incidence of stroke remain high due to the ageing population, with nearly three-quarters of stroke related events experienced by people over the age of 65 [2], [3]. This increasing demand for rehabilitation facilities has been seen as a significant healthcare problem worldwide [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Component-Level Tuning of Kinematic Features From Composite Therapist Impressions of Movement Quality

Venkataraman

Turaga

Baran

et al. 2016

IEEE J. Biomed. Health Inform.

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In this paper, we propose a general framework for tuning component-level kinematic features using therapists’ overall impressions of movement quality, in the context of a Home-based Adaptive Mixed Reality Rehabilitation (HAMRR) system. We propose a linear combination of non-linear kinematic features to model wrist movement, and propose an approach to learn feature thresholds and weights using high-level labels of overall movement quality provided by a therapist. The kinematic features are chosen such that they correlate with the quality of wrist movements to clinical assessment scores. Further, the proposed features are designed to be reliably extracted from an inexpensive and portable motion capture system using a single reflective marker on the wrist. Using a dataset collected from ten stroke survivors, we demonstrate that the framework can be reliably used for movement quality assessment in HAMRR systems. The system is currently being deployed for large-scale evaluations, and will represent an increasingly important application area of motion capture and activity analysis.

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Indirect Myocardial Revascularization

Cited by 11 publications

References 4 publications

Empowering Adult Stem Cells for Myocardial Regeneration V2.0

Empowering Adult Stem Cells for Myocardial Regeneration V2.0

Examining the association between perceived discrimination and heart rate variability in African Americans.

Component-Level Tuning of Kinematic Features From Composite Therapist Impressions of Movement Quality

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