Indirect rapid prototyping of sol-gel hybrid glass scaffolds for bone regeneration – Effects of organic crosslinker valence, content and molecular weight on mechanical properties

Hendrikx, Stephan; Kascholke, Christian; Flath, Tobias; Schümann, Dirk; Gressenbuch, Mathias; Schulze, Fritz Peter; Hacker, Michael C.; Schulz‐Siegmund, Michaela

doi:10.1016/j.actbio.2016.02.038

Cited by 22 publications

(13 citation statements)

References 58 publications

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“…However, while the quality of the regenerate was similar to that obtained by bone grafting alone, it was not significantly different from that obtained using bioactive glass alone (24). More recently, Hendrikx et al developed a homogenous gelatin-glass material that would allow for improved scaffold shaping, as it lacks the brittleness seen in bioactive glass alone (25). …”

Section: Translational Cell-based Studiesmentioning

confidence: 99%

Stem Cells in Bone Regeneration

Walmsley

Ransom

Zielins

et al. 2016

Stem Cell Rev and Rep

131

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Bone has the capacity to regenerate and repair itself. However, this capacity may be impaired or lost depending on the size of the defect or the presence of certain disease states. In this review, we discuss the key principles underlying bone healing, efforts to characterize bone stem and progenitor cell populations, and the current status of translational and clinical studies in cell-based bone tissue engineering. Though barriers to clinical implementation still exist, the application of stem and progenitor cell populations to bone engineering strategies has the potential to profoundly impact regenerative medicine.

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Section: Translational Cell-based Studiesmentioning

confidence: 99%

Stem Cells in Bone Regeneration

Walmsley

Ransom

Zielins

et al. 2016

Stem Cell Rev and Rep

131

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“…The 2- to 4-armed organic crosslinkers with small organic core molecules functionalized with ICPTES were synthesized to crosslink a pure silica sol. Scaffolds fabricated by indirect rapid prototyping from this hybrid material were used for assessment of the effect of crosslinkers’ size and content on the mechanical properties [161].…”

Section: Bone Tissue Engineering Scaffolds Encompass the Chemistrymentioning

confidence: 99%

Bone Repair and Regenerative Biomaterials: Towards Recapitulating the Microenvironment

et al. 2019

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Biomaterials and tissue engineering scaffolds play a central role to repair bone defects. Although ceramic derivatives have been historically used to repair bone, hybrid materials have emerged as viable alternatives. The rationale for hybrid bone biomaterials is to recapitulate the native bone composition to which these materials are intended to replace. In addition to the mechanical and dimensional stability, bone repair scaffolds are needed to provide suitable microenvironments for cells. Therefore, scaffolds serve more than a mere structural template suggesting a need for better and interactive biomaterials. In this review article, we aim to provide a summary of the current materials used in bone tissue engineering. Due to the ever-increasing scientific publications on this topic, this review cannot be exhaustive; however, we attempted to provide readers with the latest advance without being redundant. Furthermore, every attempt is made to ensure that seminal works and significant research findings are included, with minimal bias. After a concise review of crystalline calcium phosphates and non-crystalline bioactive glasses, the remaining sections of the manuscript are focused on organic-inorganic hybrid materials.

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“…The basic chemical principle of sol–gel processing is the transformation of Si─OR─ and Si─OH─ containing materials into inorganic network by using hydrolysis and condensation reactions. The number of siloxane groups (Si─O─Si) has to be maximized and consequently the number of silanol (Si─OH) and alkoxy (Si─OR) groups has to be minimized in order to obtain a stable gel .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and ionic conductivity of electrospun organic–inorganic hybrid gel electrolytes

Aytan

Uğur

Kayaman‐Apohan

2019

Polymer Engineering & Sci

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In this work, we described the synthesis of organic–inorganic hybrid gel electrolytes combining electrospinning, sol–gel, and ultraviolet (UV) curing techniques in order to investigate their ionic conductivity properties. First, 3‐glycidyloxypropyl trimethoxysilane modified polyamic acid and alkoxysilane functional poly(dimethyl siloxane) were electrospun together. Then, the following thermal imidization, the obtained fiber was cured in the UV curable gel formulation. To improve the interaction between fiber and gel matrix, 3‐(trimethoxysilyl)propyl methacrylate was partly hydrolyzed and then used as a bifunctional crosslinker. Finally, the membrane was soaked into 0.5 M LiFP6 salt solution to obtain organic–inorganic hybrid gel electrolytes. The chemical structure, ionic conductivity, and range of electrochemical stability window of the photocured nanocomposite electrolytes were investigated by using FTIR, thermogravimetric analysis, differential scanning calorimetry, electrochemical impedance spectroscopy, linear sweep voltammetry, and SEM analysis. The acquired results from experiments indicate that a convenient nanocomposite electrolyte for lithium‐ion batteries with high electrolyte (Li salt) uptake, adequate conductivity (1.02 × 10−3 S cm−1) at ambient temperature and electrochemically stable between 1 and 6 V had been prepared. POLYM. ENG. SCI., 60:619–629, 2020. © 2019 Society of Plastics Engineers

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Indirect rapid prototyping of sol-gel hybrid glass scaffolds for bone regeneration – Effects of organic crosslinker valence, content and molecular weight on mechanical properties

Cited by 22 publications

References 58 publications

Stem Cells in Bone Regeneration

Stem Cells in Bone Regeneration

Bone Repair and Regenerative Biomaterials: Towards Recapitulating the Microenvironment

Synthesis, characterization, and ionic conductivity of electrospun organic–inorganic hybrid gel electrolytes

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