Individual and combined association analysis of famine exposure and serum uric acid with hypertension in the mid-aged and older adult: a population-based cross-sectional study

Zhang, Lin; Liu, Yang; Wang, Congzhi; Yuan, Ting; Zhang, Dongmei; Wei, Huimin; Li, Jing; Lei, Yunxiao; Sun, Lu; Li, Xiaoping; Hua, Ying; Che, Hengying; Li, Yuanzhen

doi:10.1186/s12872-021-02230-z

Cited by 21 publications

(20 citation statements)

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“…The numbers of the condition of the chronic disease were classified into three categories: 0, 1–2, and 3–14. The categories have been widely used in our previous studies ( 1 , 24 – 26 , 28 – 31 ).…”

Section: Methodsmentioning

confidence: 99%

Frailty and Incident Depressive Symptoms During Short- and Long-Term Follow-Up Period in the Middle-Aged and Elderly: Findings From the Chinese Nationwide Cohort Study

Liu

Xu²,

Guo

et al. 2022

Front. Psychiatry

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ObjectivePrefrailty and frailty are two common conditions among older individuals. Recent studies have reported the association between frailty and depressive symptoms, but whether those conditions could predict depressive symptoms is still inconsistent in a few longitudinal studies. In our study, we aimed to estimate the cross-sectional and longitudinal associations between frailty and incident depressive symptoms in a nationally representative sample of community-dwelling middle-aged and older Chinese adults.MethodData were obtained from the China Health and Retirement Longitudinal Study (CHARLS), which included 17,284 adults aged ≥ 45 years. Participants were followed every two years using a face-to-face, computer-aided personal interview (CAPI) and structured questionnaire. We excluded participants with no follow-up data. The numbers of individuals who completed the baseline surveys were 2,579 and follow-up surveys were 839 for the short-term (2 years from 2011 to 2013) and 788 for the long-term (4 years from 2011 to 2015). In addition, Frailty was measured by the Fried criteria and depressive symptoms were estimated by the Chinese version of the Center for Epidemiologic Studies-Depression scale (CES-D). Logistic regression was used to analyze the odds ratio (OR), and 95% confidence interval (CI) for the cross-sectional associations of frailty and its components with depressive symptoms in the participants at baseline. Cox proportional hazards analysis was conducted using the hazard ratio (HR), and 95% confidence interval (CI) for the prospective associations of baseline frailty and pre-frailty and its component in the participants without depressive symptoms at baseline.ResultsAt baseline, 57.93% of participants had depressive symptoms and 55.84% had pre-frail and 11.63% had frailty. In the cross-sectional analysis, both pre-frailty (OR = 5.293, 95%CI 4.363–6.422) and frailty (OR = 16.025, 95%CI 10.948–23.457) were associated with depressive symptoms. In the longitudinal analysis, frailty [HR = 1.395 (0.966–2.013)] and pre-frailty [HR = 2.458 (0.933, 6.479)] were not significantly associated with incident depressive symptoms in a full-adjusted model among participants free of baseline depressive symptoms during the short-term. However, frailty [HR = 1.397 (1.017, 1.920)] and pre-frailty [HR = 2.992 (1.210, 7.397)] were significantly associated with incident depressive symptoms during the short term. In the components of frailty, slowness [HR = 1.597 (1.078, 2.366)] was associated with an increased risk of depressive symptoms onset during the short-term. Weakness [HR = 2.08 (1.055, 4.104)] and exhaustion [HR = 1.928 (1.297, 2.867)] were associated with increased risk of depressive symptoms onset during the short-term.ConclusionAmong the middle-aged and older adults, frailty, pre-frailty did not predict depressive symptoms during 2 years of follow-up, when accounting for the potential confounders, slowness considered alone predicted depressive symptoms. Additionally, frailty, pre-frailty predicted depressive symptoms during 4 years of follow-up, when accounting for the potential confounders, weakness and exhaustion considered alone predicted depressive symptoms.

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Section: Methodsmentioning

confidence: 99%

Frailty and Incident Depressive Symptoms During Short- and Long-Term Follow-Up Period in the Middle-Aged and Elderly: Findings From the Chinese Nationwide Cohort Study

Liu

Xu²,

Guo

et al. 2022

Front. Psychiatry

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“…History of cardiovascular diseases and liver disease, antihyperlipidaemic drugs, and antidiabetic drugs were categorised in ‘yes’ or ‘no’. Most variables were used in our previous studies 24–30…”

Section: Methodsmentioning

confidence: 99%

Mediator or moderator? The role of obesity in the association between age at menarche and blood pressure in middle-aged and elderly Chinese: a population-based cross-sectional study

et al. 2022

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ObjectiveWe investigated the moderation/mediation between the age of menarche and obesity parameters in predicting blood pressure (BP) in middle-aged and elderly Chinese.DesignOur study is a population-based cross-sectional study.SettingParticipants in this study came from the China Health and Retirement Longitudinal Study (CHARLS).ParticipantsThe analytical sample included 4513 participants aged 45–96 years.Main outcome measurementsData were selected from the CHARLS, a cross-sectional study. Between-group differences were evaluated using χ2, t-test and one-way analysis of variance. The trend of related variables by characteristics was also tested using contrast analysis, as appropriate. Then, correlations between characteristics, moderator, mediator, and independent and dependent variables were used by Spearman’s correlation test and Pearson’s correlation test. Finally, the mediation analysis was performed by model 4 in PROCESS V3.3 macro for SSPSS, and moderation analysis was used by model 1 for assessment. All covariates were adjusted in the moderation or mediation models.ResultsIn the correlation analysis, body mass index (BMI) and waist circle (WC) level were positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) in women (BMI and DBP: r=0.221, p<0.001; WC and DBP: r=0.183, p<0.001; BMI and SBP: r=0.129, p<0.001; WC and SBP: r=0.177, p<0.001). Age of menarche was negatively correlated with DBP (r=−0.060, p<0.001). However, the age of menarche was not significantly correlated with SBP (r=−0.014, p=0.335). In the moderator analysis, after controlling for the potential confounders, the interaction term of obesity parameters×age of menarche was not significant for predicting either DBP (BMI: B=0.0260, SE=0.0229, p=0.2556, 95% CI −0.0189 to 0.071; WC: B=0.0099, SE=0.0074, p=0.1833, 95% CI −0.0047 to 0.0244) or SBP (BMI: B=0.0091, SE=0.0504, p=0.8561, 95% CI −0.0897 to 0.108; WC: B=−0.0032, SE=0.0159, p=0.8427, 95% CI −0.0343 to 0.028). All correlations were significant correlation between age of menarche, obesity parameters and BP except the path of the menarche age→SBP (with the addition of the BMI indicator: β=−0.0004, B=−0.0046, p=0.9797, 95% CI −0.3619 to 0.3526; with the addition of the WC indicator: β=0.0004, B=0.0044, p=0.9804, 95% CI −0.3439 to 0.3526) in crude model. In general, after controlling for potential confounders, BMI (DBP: β=−0.0471, B= −0.2682, p=0.0021, 95% CI −0.4388 to –0.0976; SBP: β=−0.0515, B=−0.6314, p<0.001, 95% CI −0.9889 to –0.2739) and WC (DBP: β=−0.0474, B= −0.2689, p<0.001, 95% CI −0.4395 to –0.0984; SBP: β=−0.0524, B=−0.6320, p<0.001, 95% CI −0.9832 to –0.2807) partly mediated the relationship between age of menarche and BP.ConclusionsThe interaction term of obesity parameters×age of menarche was not significant for predicting either DBP or SBP in women. Moreover, obesity parameters partly mediated the relationship between the age of menarche and BP.

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“…These data were collected by self-report method. Most variables were depending on our previous research studies [51][52][53][54][55][56][57][58][59][60][61].…”

Section: Baseline Characteristicsmentioning

confidence: 99%

Separate and combined effects of famine exposure and menarche age on hypertension among the middle-aged and elderly Chinese: a population-based cross-sectional study

Wang

Yuan

et al. 2022

Preprint

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Background: Numerous epidemiologic studies had explored the relationship between hunger experience or menarche age and the risk of hypertension independently, and there is no consensus about this study. The objective of this paper was to probe the single and combined effect of famine exposure and menarche age among the middle-aged and elderly Chinese who were exposed to the famine (1959-1961).Methods: 6512 participants in this research were chosen from the China Health and Retirement Longitudinal Study (CHARLS), the study sample included 6512 individuals aged 45 to 90 years. The differences between baseline characteristics of famine exposure/menarche age were evaluated using thet-test and F-test. Finally, multivariable-adjusted logistic regression models examined association of famine exposure and menarche age with the odds of prevalence of hypertension.Results: Among the 6512 individuals, 502(7.71%) people had not been exposed to the Chinese famine, 459(7.05%) people had been exposed to the Chinese famine in fetal life, 1760(27.03%) people, and 1645(25.26%) people had been exposed to the famine during childhood and adolescence/adulthood, respectively. 2118(32.53%) people reported having hypertension. Furthermore, 4109(63.10%) people reported menarche age was under 15 years, while 2403(36.90%) people reported menarche age was above 16 years. In multivariable-adjusted model, famine exposure and menarche age were associated with hypertension [(1) separate association famine exposure, menarche age with hypertension: the fetal exposed vs. no exposed group, 1.22 (95% CI 0.98, 1.51); childhood-exposed vs. no exposed group, 1.58 (95% CI 1.33, 1.88); the adolescence/adult-exposed vs. no exposed group, 3.32 (95%CI 2.77, 3.99); P for trend=0.000; less than 15 years vs More than 16 years group, 1.19 (95%CI 1.07,1.33). (2) The combined associations of menarche age and famine exposure with the hypertension. The fetal exposed vs. no exposed group among the menarche age less than 15 years 1.24 (95%CI 0.92,1.68), childhood-exposed vs. no exposed group among the menarche age less than 15 years 1.64 (95%CI 1.29,2.08), the adolescence/adult-exposed vs no exposed group among the menarche age less than 15 years 3.54 (95%CI 2.78, 4.51); P for trend 0.000. The group less than 15 years vs more than 16 years group 1.34 (95%CI 1.00, 1.81), the fetal exposed vs. no exposed group among the menarche age more than 16 years group 1.62 (95%CI 2.18, 2.22), childhood-exposed vs no exposed group among the menarche age more than 16 years 2.13(95%CI 1.65, 2.74), the adolescence/adult-exposed vs no exposed group among the menarche age more than 16years 4.43(95%CI 3.38, 5.80); P for trend=0.000. In general, compared with the combination of the menarche age less than 15 years and no-exposed famine stage, interaction analysis in the multivariable-adjusted model, other groups trended towards higher odds of hypertension [the most significant increase in odds, adolescence/adult exposed stage with menarche age more than 16 years 4.43(95%CI 3.38, 5.80)].Conclusions: Our study data support a strongly positive separate and combined effects of menarche age and famine exposure on hypertension in the middle-aged and elderly Chinese.

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Individual and combined association analysis of famine exposure and serum uric acid with hypertension in the mid-aged and older adult: a population-based cross-sectional study

Cited by 21 publications

References 63 publications

Frailty and Incident Depressive Symptoms During Short- and Long-Term Follow-Up Period in the Middle-Aged and Elderly: Findings From the Chinese Nationwide Cohort Study

Frailty and Incident Depressive Symptoms During Short- and Long-Term Follow-Up Period in the Middle-Aged and Elderly: Findings From the Chinese Nationwide Cohort Study

Mediator or moderator? The role of obesity in the association between age at menarche and blood pressure in middle-aged and elderly Chinese: a population-based cross-sectional study

Separate and combined effects of famine exposure and menarche age on hypertension among the middle-aged and elderly Chinese: a population-based cross-sectional study

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