Individual and combined effects of berberine and santonin on spore germination of some fungi

Singh, Bheeshma Pratap; Srivastava, J. S.; Khosa, R. L.

doi:10.1007/bf02873592

Cited by 36 publications

(14 citation statements)

References 21 publications

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“…Nenaah (2010) found that the potentiality of the alkaloids of Peganum harmala as antibacterial and antifungal increased when tested as binary or total (crude) alkaloidal mixture, suggesting a kind of synergism and antagonism among these compounds. Singh et al (2001) also obtained similar results regarding the two alkaloids, berberine and santonin, isolated from the rhizomes of Berberis aristata and the flower buds of Artemisia maritima, respectively. They found that a mixture of both alkaloids was more effective.…”

Section: Cytogenetic Analysissupporting

confidence: 62%

Cytogenetic Effects of Crude Extracts of Peganum harmala Seeds and Their Effects on Vicia faba Plants

Mekki¹

2014

CYTOLOGIA

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SummaryThe present study evaluates the genotoxic and cytotoxic effects of the crude water and ethanol extracts of Peganum harmala L. (Zygophyllaceae) on the Vicia faba L. M1 generation. Two types of treatments were carried out in this study. In the first type, the germinated root tips were treated with four dilutions of the water extract and ethanol extract (12.5, 25, 50 and 100%). All concentrations were applied for 3, 6, 12 and 24 h. In the second treatment, soaked V. faba seeds were treated with the same concentrations of the two extracts for 3, 6, 12, and 24 h, and then planted to raise the M1 generation. Root tips were squashed after Feulgen staining, and the prepared slides were analyzed for chromosomal aberrations and mitotic index changes. Significant concentrationdependent increase and duration-dependent decrease of MI were observed with aqueous extracts, while with ethanol extracts, the MI showed concentration-and duration-dependent decrease. The two extracts induced significant (p 0.01) increase in the percentage of nuclear and chromosomal aberrations. Concentration-and duration-dependent increase in the number of branches per plant and decrease in the other studied growth parameters were also recorded for all treatments with the water and ethanol extracts.

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Section: Cytogenetic Analysissupporting

confidence: 62%

Cytogenetic Effects of Crude Extracts of Peganum harmala Seeds and Their Effects on Vicia faba Plants

Mekki¹

2014

CYTOLOGIA

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“…α-Santonin is known to be a potent anti-parasitic agent, and in its α,β forms exhibits anti-pyretic activity in a fashion similar to that of dopamine 1 . It is known to be effective against several species of fungi via the inhibition of spore germination 2 and hence is used as biocontrol agent. Chemically modifi ed derivatives of α-santonin are also known to confer the ability to induce the differentiation of human promyelocytic leukemia cells 3 .…”

Section: Introductionmentioning

confidence: 99%

Periplasmically located α-santonin binding factor in Sphingomonas paucimobilis strain S ATCC 43388

2007

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A marked reduction in uptake of α-santonin, accompanied by loss of ability of cells to transform the substrate, is observed on shocking Sphingomonas paucimobilis strain S ATCC 43388 cells by freeze -thaw method. The shock fl uid shows a 26% quench in fl uorescence at 350nm on incubation with the substrate. Addition of shock fl uid to the freeze thawed cells restores both uptake as well as transformation of α-santonin to near normal.

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“…It has been used previously as an antiparasite preparation [7]. Other types of activity have recently been found for it, for example, antipyretic, anti-inflammatory, and fungicidal [8,9]. Santonin presents several reactive centers and is a convenient starting material for further chemical modification.…”

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confidence: 99%

Synthesis and cytotoxic activity of α-santonin amino-derivatives

et al. 2009

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Previously unknown amino-derivatives of the natural sesquiterpene lactone α-santonin were synthesized. The activity of the products against several human tumor-cell lines was studied.Natural sesquiterpene lactones exhibit various types of biological activity including antitumor activity [1]. A study of structure-activity relationships has found that high cytotoxicity correlates with the presence of an exocyclic double bond in the lactone ring [2]. Furthermore, the presence of an activated double bond allows modification (by a Michael reaction), introduction of new pharmacophores, and production of water-soluble and transportable forms [3].Compounds containing in a lactone ring not a methylene group but a methyl are found among the large variety of natural sesquiterpene γ-lactones isolated from plants of the family Asteraceae. For example, austricin (1) [4] was isolated from Artemisia leucodes Schrenk, A. austriaca Jacg.; arborescin (2) [5], from A. arborescens L.; and balchanolide (3) [6], from Achillea millefolium L. and A. balchanorum H. Krasch, etc.These and other sesquiterpene lactones with a methyl in the lactone ring are found in plants in large quantities and can be considered promising synthons for modification in order to introduce a new reactive center such as an activated exocyclic double bond that reacts readily with nuclophiles. These transformations could produce new derivatives of natural sesquiterpene lactones containing pharmacophores and their water-soluble or transportable forms.Our goal was to use α-santonin (4), which is isolated from certain Artemisia species (Asteracea), as an example to demonstrate the ability to introduce an active methylene into the lactone ring, to use the resulting lactone as a synthon for synthesis of previously unknown amino-derivatives of lactones, and to study their cytotoxic activity.Chemical and biochemical transformations of α-santonin and its pharmacological properties have been studied already for over 100 years. It has been used previously as an antiparasite preparation [7]. Other types of activity have recently been found for it, for example, antipyretic, anti-inflammatory, and fungicidal [8,9]. Santonin presents several reactive centers and is a convenient starting material for further chemical modification. Various transformations involving the dienone ring have been reported [10][11][12][13]. Methods for opening the lactone ring using various reagents are known [1,14,15].

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Individual and combined effects of berberine and santonin on spore germination of some fungi

Cited by 36 publications

References 21 publications

Cytogenetic Effects of Crude Extracts of <i>Peganum harmala</i> Seeds and Their Effects on <i>Vicia faba</i> Plants

Cytogenetic Effects of Crude Extracts of <i>Peganum harmala</i> Seeds and Their Effects on <i>Vicia faba</i> Plants

Periplasmically located α-santonin binding factor in Sphingomonas paucimobilis strain S ATCC 43388

Synthesis and cytotoxic activity of α-santonin amino-derivatives

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