As science and technology change our world, anticipating the unintended consequences becomes critical. This article presents a framework for identifying unintended consequences, especially unanticipated-unintended consequences, and prioritizing the necessary actions to mitigate or adapt. Content for the framework, and the distinctions among the anticipated-intended, anticipated-unintended, and unanticipated-unintended consequences, are generated with four scenario types: evolution over time, market-saturation, interventions in tightly coupled systems, and existential risk of human extinction. To validate the framework, each scenario type is applied to historical and emerging technologies to anticipate the unintended consequences, including the causes, initiators, effects, actions to mitigate or adapt, and unmet obligations to future generations.