2012
DOI: 10.1016/j.bbr.2012.05.023
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Individual differences are critical in determining modafinil-induced behavioral sensitization and cross-sensitization with methamphetamine in mice

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Cited by 14 publications
(9 citation statements)
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“…We showed that the same modafinil dose that enhanced visual retention in METH-treated mice, 90 mg/Kg, also elicited a cross-sensitization effect in locomotion. A previous study in mice also found locomotor cross-sensitization between METH and modafinil assessed by challenging modafinil -pretreated mice with 1 mg/Kg METH, and METH-pretreated mice with 50 mg/Kg modafinil (Soeiro et al, 2012). Our results on cross-sensitization between METH and modafinil raise the possibility that neuroadaptations induced by METH and evidenced by acute administration of modafinil might be related to the beneficial effects of modafinil on cognition.…”
Section: Discussionmentioning
confidence: 79%
“…We showed that the same modafinil dose that enhanced visual retention in METH-treated mice, 90 mg/Kg, also elicited a cross-sensitization effect in locomotion. A previous study in mice also found locomotor cross-sensitization between METH and modafinil assessed by challenging modafinil -pretreated mice with 1 mg/Kg METH, and METH-pretreated mice with 50 mg/Kg modafinil (Soeiro et al, 2012). Our results on cross-sensitization between METH and modafinil raise the possibility that neuroadaptations induced by METH and evidenced by acute administration of modafinil might be related to the beneficial effects of modafinil on cognition.…”
Section: Discussionmentioning
confidence: 79%
“…These results are in agreement with our previous study (Wuo-Silva et al, 2011) showing that pre-treatment with repeated injections of cocaine enhanced the locomotor stimulant effects of an acute injection of modafinil, and pre-treatment with repeated injections of modafinil enhanced the locomotor stimulant effects of an acute injection of cocaine in mice. Similarly, Soeiro et al (2012) demonstrated cross-sensitization between methamphetamine and modafinil in mice. Altogether, the bidirectional cross-sensitization between modafinil and other psychostimulants seen in the present study and in previous ones suggests that modafinil shares common neurobiological mechanisms with psychostimulants related to both the induction and the expression phases of sensitization.…”
Section: Discussionmentioning
confidence: 89%
“…Cross-sensitization (wherein repeated administration of one agent potentiates the locomotor response to acute administration of another), is taken as indirect evidence that two agents act on a similar neurobiological substrate. Mice subjected to repeated administration of modafinil exhibit potentiated locomotor responses to acutely administered methamphetamine (59). Likewise, mice subjected to repeated administration of methamphetamine exhibit potentiated locomotor responses to acutely administered modafinil (59).…”
Section: Why Do Modafinil and Other Commonly Used (And Abused) Dat Inmentioning
confidence: 99%
“…Mice subjected to repeated administration of modafinil exhibit potentiated locomotor responses to acutely administered methamphetamine (59). Likewise, mice subjected to repeated administration of methamphetamine exhibit potentiated locomotor responses to acutely administered modafinil (59). While not mechanistic, these cross-sensitization studies suggest that modafinil and amphetamines share a common, or at least overlapping, neurobiological substrate.…”
Section: Why Do Modafinil and Other Commonly Used (And Abused) Dat Inmentioning
confidence: 99%